Q7LWY0
Gene name |
truB |
Protein name |
Probable tRNA pseudouridine synthase B |
Names |
tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase |
Species |
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) |
KEGG Pathway |
pfu:PF1785 |
EC number |
5.4.99.25: Transferring other groups |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
14 structures for Q7LWY0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2EY4 | X-ray | 211 A | A/B | 1-333 | PDB |
| 2HVY | X-ray | 230 A | A | 1-340 | PDB |
| 2RFK | X-ray | 287 A | A | 5-338 | PDB |
| 3HAX | X-ray | 211 A | A | 1-340 | PDB |
| 3HAY | X-ray | 499 A | A | 1-340 | PDB |
| 3HJW | X-ray | 235 A | A | 8-334 | PDB |
| 3HJY | X-ray | 365 A | A | 8-334 | PDB |
| 3LWO | X-ray | 286 A | A | 1-340 | PDB |
| 3LWP | X-ray | 250 A | A | 1-340 | PDB |
| 3LWQ | X-ray | 268 A | A | 1-340 | PDB |
| 3LWR | X-ray | 220 A | A | 1-340 | PDB |
| 3LWV | X-ray | 250 A | A | 1-340 | PDB |
| 3MQK | X-ray | 280 A | A | 8-335 | PDB |
| AF-Q7LWY0-F1 | Predicted | AlphaFoldDB |
No variants for Q7LWY0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q7LWY0 | |||||
No associated diseases with Q7LWY0
6 regional properties for Q7LWY0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | PUA domain | 251 - 325 | IPR002478 |
| domain | Pseudouridine synthase II, N-terminal | 67 - 118 | IPR002501-1 |
| domain | Pseudouridine synthase II, N-terminal | 120 - 180 | IPR002501-2 |
| domain | Uncharacterised domain CHP00451 | 240 - 320 | IPR004521 |
| domain | Dyskerin-like | 4 - 63 | IPR012960 |
| domain | tRNA pseudouridylate synthase B, C-terminal | 181 - 247 | IPR032819 |
Functions
| Description | ||
|---|---|---|
| EC Number | 5.4.99.25 | Transferring other groups |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| tRNA pseudouridine synthase activity | Catalysis of the reaction: tRNA uridine = tRNA pseudouridine. Conversion of uridine in a tRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| tRNA pseudouridine synthesis | The intramolecular conversion of uridine to pseudouridine in a tRNA molecule. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MARDEVRRIL | PADIKREVLI | KDENAETNPD | WGFPPEKRPI | EMHIQFGVIN | LDKPPGPTSH |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EVVAWIKKIL | NLEKAGHGGT | LDPKVSGVLP | VALEKATRVV | QALLPAGKEY | VALMHLHGDV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PEDKIIQVMK | EFEGEIIQRP | PLRSAVKRRL | RTRKVYYIEV | LEIEGRDVLF | RVGVEAGTYI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RSLIHHIGLA | LGVGAHMSEL | RRTRSGPFKE | DETLITLHDL | VDYYYFWKED | GIEEYFRKAI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QPMEKAVEHL | PKVWIKDSAV | AAVTHGADLA | VPGIAKLHAG | IKRGDLVAIM | TLKDELVALG |
| 310 | 320 | 330 | |||
| KAMMTSQEML | EKTKGIAVDV | EKVFMPRDWY | PKLWEKRDRS |