Q7D3B2

PR
Gene name
lcdH (Atu5344)
Protein name
L-carnitine dehydrogenase
Names
CDH, L-CDH
Species
Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58))
KEGG Pathway
atu:Atu5344
EC number
1.1.1.108: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

277-347 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7D3B2

Entry ID Method Resolution Chain Position Source
AF-Q7D3B2-F1 Predicted AlphaFoldDB

No variants for Q7D3B2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7D3B2

No associated diseases with Q7D3B2

2 regional properties for Q7D3B2

Type Name Position InterPro Accession
domain 3-hydroxyacyl-CoA dehydrogenase, C-terminal 179 - 245 IPR006108
domain 3-hydroxyacyl-CoA dehydrogenase, NAD binding 2 - 169 IPR006176

Functions

Description
EC Number 1.1.1.108 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
carnitine 3-dehydrogenase activity Catalysis of the reaction: carnitine + NAD(+) = 3-dehydrocarnitine + H(+) + NADH.
NAD+ binding Binding to the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions.

2 GO annotations of biological process

Name Definition
carnitine catabolic process The chemical reactions and pathways resulting in the breakdown of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane.
fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKIAAIGGGV IGGGWIARFI LAGHDVTVFD PHPEANRIVT EVMANAAEAW GRLYQSPLPK
70 80 90 100 110 120
PGSINWASSI AEAVAGADYI QESVPERLDL KHRIIAEIEA TASPQAIIAS STSGFKPSEL
130 140 150 160 170 180
REGSVHSERV IVAHPFNPVY LLPVVEVVGG GVAAQRASDI LVSVGMKPVQ IGREIDAHIG
190 200 210 220 230 240
DRLLEAIWRE ALWLVKDGIA TTQEIDDIIR YGFGLRWAQM GLFETYRIAG GEAGMRHFLA
250 260 270 280 290 300
QFGPALKWPW TKLMDVPEFN DELIDLIAGQ SDAQSGAYSI RELERIRDSN LIGIFHALKA
310 320 330 340 350 360
NDWGAGQTVK AMENRFYARN GKVQADYPLR LHEAHVNGGW VDYNGHMTEF RYLQVLGDAT
370 380 390 400 410 420
DALLIHIGLD ADYRAAGHSA YTVETHIRHL AEVKAGARLT VETRLLGYDD KRLRLHHAIL
430 440 450 460 470 480
NEDGETVATG EHMLLHVDTK ANRTVAMPPA LMRALDHLNA QEEGPLPDHA GSGIRAVRLK
ETSA