Q79FX8
Gene name |
mmaA4 (hma, mma4, Rv0642c) |
Protein name |
Hydroxymycolate synthase MmaA4 |
Names |
Mycolic acid methyltransferase, MA-MT, S-adenosylmethionine-dependent methyltransferase, AdoMet-MT, SAM-MT |
Species |
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
KEGG Pathway |
mtu:Rv0642c |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
13 structures for Q79FX8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2FK7 | X-ray | 210 A | A | 4-301 | PDB |
| 2FK8 | X-ray | 200 A | A | 4-301 | PDB |
| 3HA3 | X-ray | 220 A | A | 4-301 | PDB |
| 3HA5 | X-ray | 230 A | A | 4-301 | PDB |
| 3HA7 | X-ray | 235 A | A | 4-301 | PDB |
| 7Q2B | X-ray | 185 A | A | 4-301 | PDB |
| 7Q2C | X-ray | 190 A | A | 4-301 | PDB |
| 7Q2D | X-ray | 189 A | A | 4-301 | PDB |
| 7Q2E | X-ray | 193 A | A | 4-301 | PDB |
| 7Q2F | X-ray | 185 A | A | 4-301 | PDB |
| 7Q2G | X-ray | 200 A | A | 4-301 | PDB |
| 7Q2H | X-ray | 175 A | A | 4-301 | PDB |
| AF-Q79FX8-F1 | Predicted | AlphaFoldDB |
No variants for Q79FX8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q79FX8 | |||||
No associated diseases with Q79FX8
No regional properties for Q79FX8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q79FX8 | |||
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| peptidoglycan-based cell wall | A protective structure outside the cytoplasmic membrane composed of peptidoglycan (also known as murein), a molecule made up of a glycan (sugar) backbone of repetitively alternating N-acetylglucosamine and N-acetylmuramic acid with short, attached, cross-linked peptide chains containing unusual amino acids. An example of this component is found in Escherichia coli. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| methyltransferase activity | Catalysis of the transfer of a methyl group to an acceptor molecule. |
| S-adenosylmethionine-dependent methyltransferase activity | Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| methylation | The process in which a methyl group is covalently attached to a molecule. |
| mycolic acid biosynthetic process | The chemical reactions and pathways resulting in the formation of mycolic acids, beta-hydroxy fatty acids with a long alpha-alkyl side chain. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTRMAEKPIS | PTKTRTRFED | IQAHYDVSDD | FFALFQDPTR | TYSCAYFEPP | ELTLEEAQYA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KVDLNLDKLD | LKPGMTLLDI | GCGWGTTMRR | AVERFDVNVI | GLTLSKNQHA | RCEQVLASID |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TNRSRQVLLQ | GWEDFAEPVD | RIVSIEAFEH | FGHENYDDFF | KRCFNIMPAD | GRMTVQSSVS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YHPYEMAARG | KKLSFETARF | IKFIVTEIFP | GGRLPSTEMM | VEHGEKAGFT | VPEPLSLRPH |
| 250 | 260 | 270 | 280 | 290 | 300 |
| YIKTLRIWGD | TLQSNKDKAI | EVTSEEVYNR | YMKYLRGCEH | YFTDEMLDCS | LVTYLKPGAA |
| A |