Q78JT3

PR
Gene name
Haao
Protein name
3-hydroxyanthranilate 3,4-dioxygenase
Names
3-hydroxyanthranilate oxygenase, 3-HAO, 3-hydroxyanthranilic acid dioxygenase, HAD
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:107766
EC number
1.13.11.6: With incorporation of two atoms of oxygen
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-44 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q78JT3

Entry ID Method Resolution Chain Position Source
AF-Q78JT3-F1 Predicted AlphaFoldDB

11 variants for Q78JT3

Variant ID(s) Position Change Description Diseaes Association Provenance
rs234856061 2 E>D No EVA
rs3389451169 26 L>P No EVA
rs3389484441 63 I>K No EVA
rs3389441944 108 R>L No EVA
rs3389484453 141 L>I No EVA
rs3389476178 192 R>K No EVA
rs3389484382 245 C>S No EVA
rs3389473730 255 L>P No EVA
rs231496917 259 G>R No EVA
rs3389483183 260 T>S No EVA
rs3389489702 269 G>C No EVA

No associated diseases with Q78JT3

No regional properties for Q78JT3

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q78JT3

Functions

Description
EC Number 1.13.11.6 With incorporation of two atoms of oxygen
Subcellular Localization
  • Cytoplasm, cytosol
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitochondrial membrane Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.

4 GO annotations of molecular function

Name Definition
3-hydroxyanthranilate 3,4-dioxygenase activity Catalysis of the reaction: 3-hydroxyanthranilate + O(2) = cis,cis-2-amino-3-(3-oxoprop-1-enyl)but-2-enedioate + H(+).
ferrous iron binding Binding to a ferrous iron ion, Fe(II).
iron ion binding Binding to an iron (Fe) ion.
oxygen binding Binding to oxygen (O2).

9 GO annotations of biological process

Name Definition
'de novo' NAD biosynthetic process from tryptophan The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD), beginning with the synthesis of tryptophan from simpler precursors; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH.
anthranilate metabolic process The chemical reactions and pathways involving anthranilate (2-aminobenzoate).
NAD biosynthetic process The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH.
neuron cellular homeostasis The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state.
quinolinate biosynthetic process The chemical reactions and pathways resulting in the formation of quinolinate, the anion of quinolinic acid, also known as 2,3-pyridinedicarboxylic acid.
quinolinate metabolic process The chemical reactions and pathways involving quinolinate, the anion of quinolinic acid, also known as 2,3-pyridinedicarboxylic acid.
response to cadmium ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
response to zinc ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus.
tryptophan catabolic process The chemical reactions and pathways resulting in the breakdown of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MERRVRVKSW VEENRASFQP PVCNKLMHQE QLKIMFVGGP NTRKDYHIEE GEEVFYQLEG
70 80 90 100 110 120
DMILRVLEQG QHRDVPIRQG EIFLLPARVP HSPQRFANTM GLVIERRRLE SELDGLRYYV
130 140 150 160 170 180
GDTEDVLFEK WFHCKDLGTQ LAPIIQEFFH SEQYRTGKPN PDQLLKELPF PLNTRSIMKP
190 200 210 220 230 240
MSLKAWLDGH SRELQAGTSL SLFGDSYETQ VIAHGQGSSK GPRQDVDVWL WQQEGSSKVT
250 260 270 280
MGGQCIALAP DDSLLVPAGT SYVWERAQGS VALSVTQDPA RKKPWW