Q76MY7

PR
Gene name
CYTH2 (PSCD2)
Protein name
Cytohesin-2
Names
PH, SEC7 and coiled-coil domain-containing protein 2
Species
Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-105 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q76MY7

Entry ID Method Resolution Chain Position Source
AF-Q76MY7-F1 Predicted AlphaFoldDB

No variants for Q76MY7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q76MY7

No associated diseases with Q76MY7

2 regional properties for Q76MY7

Type Name Position InterPro Accession
domain Sec7 domain 54 - 243 IPR000904
domain Pleckstrin homology domain 259 - 377 IPR001849

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Peripheral membrane protein
  • Cytoplasm
  • Cell projection
  • Cell projection, growth cone
  • Recruited to the cell membrane through its association with ARL4A, ARL4C and ARL4D
  • Requires also interaction with phosphoinositides for targeting to plasma membrane
  • In differentiating neuroblastoma cells, colocalizes with CCDC120 in both neurite shaft and growth cone areas
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
growth cone The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
guanyl-nucleotide exchange factor activity Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.
inositol 1,4,5 trisphosphate binding Binding to inositol 1,4,5 trisphosphate.
lipid binding Binding to a lipid.

1 GO annotations of biological process

Name Definition
regulation of ARF protein signal transduction Any process that modulates the frequency, rate or extent of ARF protein signal transduction.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEDGVYEPPD LTPEERMELE NIRRRKQELL VEIQRLREEL SEAMSEVEGL EANEGSKTLQ
70 80 90 100 110 120
RNRKMAMGRK KFNMDPKKGI QFLVENELLQ NTPEEIARFL YKGEGLNKTA IGDYLGEREE
130 140 150 160 170 180
LNLAVLHAFV DLHEFTDLNL VQALRQFLWS FRLPGEAQKI DRMMEAFAQR YCLCNPGVFQ
190 200 210 220 230 240
STDTCYVLSF AVIMLNTSLH NPNVRDKPGL ERFVAMNRGI NEGGDLPEEL LRNLYDSIRN
250 260 270 280 290 300
EPFKIPEDDG NDLTHTFFNP DREGWLLKLG GRVKTWKRRW FILTDNCLYY FEYTTDKEPR
310 320 330 340 350 360
GIIPLENLSI REVDDPRKPN CFELYIPNNK GQLIKACKTE ADGRVVEGNH MVYRISAPTQ
370 380 390
EEKDEWIKSI QAAVSVDPFY EMLAARKKRI SVKKKQEQP