Q76KJ5
Gene name |
Polr1g |
Protein name |
DNA-directed RNA polymerase I subunit RPA34 |
Names |
A34.5, DNA-directed RNA polymerase I subunit G, RNA polymerase I-associated factor PAF49 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:70333 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q76KJ5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q76KJ5-F1 | Predicted | AlphaFoldDB |
34 variants for Q76KJ5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3396888058 | 5 | Q>R | No | EVA | |
| rs3388878403 | 6 | A>T | No | EVA | |
| rs3396888043 | 20 | E>* | No | EVA | |
| rs3388878442 | 20 | E>G | No | EVA | |
| rs252718470 | 73 | L>V | No | EVA | |
| rs214806737 | 85 | S>I | No | EVA | |
| rs32410945 | 90 | R>G | No | EVA | |
| rs263783987 | 169 | R>S | No | EVA | |
| rs212690603 | 219 | F>Y | No | EVA | |
| rs243455432 | 226 | A>T | No | EVA | |
| rs584913436 | 240 | A>V | No | EVA | |
| rs3388877172 | 250 | K>N | No | EVA | |
| rs231766097 | 252 | T>A | No | EVA | |
| rs214645488 | 263 | V>M | No | EVA | |
| rs245528842 | 273 | F>L | No | EVA | |
| rs232801674 | 275 | F>S | No | EVA | |
| rs227327523 | 287 | D>E | No | EVA | |
| rs3388878416 | 287 | D>V | No | EVA | |
| rs256484765 | 295 | I>T | No | EVA | |
| rs3397502462 | 298 | D>E | No | EVA | |
| rs3397502470 | 299 | S>C | No | EVA | |
| rs3397589035 | 299 | S>T | No | EVA | |
| rs3388858810 | 303 | V>A | No | EVA | |
| rs3388878429 | 308 | Q>* | No | EVA | |
| rs3388858806 | 334 | M>K | No | EVA | |
| rs3388885118 | 337 | P>L | No | EVA | |
| rs3388858775 | 340 | L>F | No | EVA | |
| rs3388885611 | 345 | H>R | No | EVA | |
| rs258931466 | 350 | L>F | No | EVA | |
| rs260427782 | 371 | G>S | No | EVA | |
| rs3397260956 | 384 | Q>H | No | EVA | |
| rs3397679844 | 384 | Q>P | No | EVA | |
| rs251388234 | 385 | G>E | No | EVA | |
| rs217997374 | 397 | A>T | No | EVA |
No associated diseases with Q76KJ5
No regional properties for Q76KJ5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q76KJ5 | |||
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| fibrillar center | A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| RNA polymerase I complex | RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| rRNA transcription | The synthesis of ribosomal RNA (rRNA), any RNA that forms part of the ribosomal structure, from a DNA template. |
| transcription by RNA polymerase I | The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAGTQACSAT | RFSCPPHFTE | MSPDSEPSRF | SLEALTGPDT | ELWLIQAPAD | FAPQCLNGRR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VPLSGSKTVK | GKLDGKKHRY | RVFTSSPQAR | EATLLASSSE | AGGRLTCAPA | PSGSLRIMEG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PQEYLLSRVP | LQLIPTSLPP | QIPAGLRPRF | SAFGGSPPVT | GPGSASALRS | PTSGKRKSTR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KGTDASSDTQ | EAVNRHGAME | VKTALGNLGV | SVKKRKRYFM | QEEMEAKTME | PVAELPVPSA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TSSKKRKKSK | GTETSQVEHT | EPVAQTEPPE | GTFLFPTKKR | KRQKEADGTE | EVDGIVADSQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PQVIVEAQEE | TILLSPTKKR | RKEKRQNLGM | EAEMGPPGVL | MVTEHSEHGL | QAEVALVSPK |
| 370 | 380 | 390 | |||
| KTKKKKGKRV | GETEAALPDD | FEPQGALAPS | KKKERGARL |