Q76B40

PR
Gene name
SMU1
Protein name
WD40 repeat-containing protein SMU1
Names
Smu-1 suppressor of mec-8 and unc-52 protein homolog
Species
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
KEGG Pathway
cge:100736555
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

69-183 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q76B40

Entry ID Method Resolution Chain Position Source
AF-Q76B40-F1 Predicted AlphaFoldDB

No variants for Q76B40

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q76B40

No associated diseases with Q76B40

11 regional properties for Q76B40

Type Name Position InterPro Accession
repeat WD40 repeat 202 - 251 IPR001680-1
repeat WD40 repeat 253 - 426 IPR001680-2
repeat WD40 repeat 428 - 470 IPR001680-3
repeat WD40 repeat 473 - 513 IPR001680-4
domain LIS1 homology motif 6 - 38 IPR006594
domain CTLH, C-terminal LisH motif 40 - 92 IPR006595
conserved_site WD40 repeat, conserved site 229 - 243 IPR019775-1
conserved_site WD40 repeat, conserved site 364 - 378 IPR019775-2
repeat G-protein beta WD-40 repeat 229 - 243 IPR020472-1
repeat G-protein beta WD-40 repeat 279 - 293 IPR020472-2
repeat G-protein beta WD-40 repeat 364 - 378 IPR020472-3

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • Nucleus speckle
  • Colocalizes with SRSF1 in nuclear speckles
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nuclear speck A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
U2-type precatalytic spliceosome A spliceosomal complex that is formed by the recruitment of the preassembled U4/U6.U5 tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U1, U2 and U4/U6.U5 snRNPs.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

2 GO annotations of biological process

Name Definition
mRNA splicing, via spliceosome The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
regulation of alternative mRNA splicing, via spliceosome Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSIEIESSDV IRLIMQYLKE NSLHRALATL QEETTVSLNT VDSIESFVAD INSGHWDTVL
70 80 90 100 110 120
QAIQSLKLPD KTLIDLYEQV VLELIELREL GAARSLLRQT DPMIMLKQTQ PERYIHLENL
130 140 150 160 170 180
LARSYFDPRE AYPDGSSKEK RRAAIAQALA GEVSVVPPSR LMALLGQALK WQQHQGLLPP
190 200 210 220 230 240
GMTIDLFRGK AAVKDVEEEK FPTQLSRHIK FGQKSHVECA RFSPDGQYLV TGSVDGFIEV
250 260 270 280 290 300
WNFTTGKIRK DLKYQAQDNF MMMDDAVLCM CFSRDTEMLA TGAQDGKIKV WKIQSGQCLR
310 320 330 340 350 360
RFERAHSKGV TCLSFSKDSS QILSASFDQT IRIHGLKSGK TLKEFRGHSS FVNEATFTQD
370 380 390 400 410 420
GHYIISASSD GTVKIWNMKT TECSNTFKSL GSTAGTDITV NSVILLPKNP EHFVVCNRSN
430 440 450 460 470 480
TVVIMNMQGQ IVRSFSSGKR EGGDFVCCAL SPRGEWIYCV GEDFVLYCFS TVTGKLERTL
490 500 510
TVHEKDVIGI AHHPHQNLIA TYSEDGLLKL WKP