Q75VR1
Gene name |
TPC1A |
Protein name |
Two pore calcium channel protein 1A |
Names |
Voltage-dependent calcium channel protein TPC1A, NtTPC1A |
Species |
Nicotiana tabacum (Common tobacco) |
KEGG Pathway |
nta:107770546 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q75VR1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q75VR1-F1 | Predicted | AlphaFoldDB |
No variants for Q75VR1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q75VR1 | |||||
No associated diseases with Q75VR1
3 regional properties for Q75VR1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | EF-hand domain | 329 - 401 | IPR002048 |
| domain | Ion transport domain | 127 - 313 | IPR005821-1 |
| domain | Ion transport domain | 434 - 680 | IPR005821-2 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plant-type vacuole | A closed structure that is completely surrounded by a unit membrane, contains liquid, and retains the same shape regardless of cell cycle phase. An example of this structure is found in Arabidopsis thaliana. |
| vacuolar membrane | The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| voltage-gated calcium channel activity | Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| calcium ion transport | The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| defense response | Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. |
| regulation of ion transmembrane transport | Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEEYLLSGES | SNSGRTRRRI | GSIFDRRDAI | AHGSAYQKAA | ALVDLAEDGI | GLPEEILEGA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SFEKAAELYF | IFTRFDFLWS | LNYLALVVLN | FFEKPLWCSK | HLAESCNNRD | YYYLGELPFL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TGAESLIFEG | VTLLLLIIHI | LFPISYEGFN | LYWRSLLNRV | KVILLLILVA | DIVVYILFLA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DFYYLPFRIA | PYLRVVFFIL | NIRELRDSFF | ILAGMLGTYL | NVVALSALFL | LFSSWLAYVF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FEDTRQGKTT | FTSYGTTLYQ | MFVLFTTSNN | PDVWIPAYKD | SRWYCLFFVL | YVLLGVYFVT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NLILAVVYDS | FKSELVKQVA | DKDRLRLRTL | KKAFSLIDEA | NNGHLNEKQC | TLLFEELNKY |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RTLPKISGDD | FKSIFSELDD | TGDFKINLDE | FADLCTAIGL | RFQKEDSLPI | FEACPNFYHS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PASEKLRGFV | RGATFEYIIV | FVLLVNLVAV | IIETTLDIQN | NSGQTFWQKV | EFTFGWLYVI |
| 490 | 500 | 510 | 520 | 530 | 540 |
| EMALKVYTYG | FENYWRDGQN | RFDFVVTWVI | VIGETATFVA | PDGLTFLSNG | EWIRYLLIAR |
| 550 | 560 | 570 | 580 | 590 | 600 |
| MLRLIRLLMH | VERYRAFVAT | FFTLIPSLVP | YLGTIFCILC | FYCSLGLQIF | GGIVNTGNPN |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LAQTDLAGND | YLLFNFNDYP | NGMVTLFNIL | VMGNWQVWMQ | SYKELTGTAW | TYAYFVSFYL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| ISVLWLLNLI | VAFVLEAFQA | EVDLEASARC | VDGDDKEAKS | ERRRNVGTKT | RSQRVDFLLH |
| 730 | |||||
| HMLRSELTEC | SNENP |