Q75VR0

PR
Gene name
TPC1B
Protein name
Two pore calcium channel protein 1B
Names
Voltage-dependent calcium channel protein TPC1B, NtTPC1B
Species
Nicotiana tabacum (Common tobacco)
KEGG Pathway
nta:107819477
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-52 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q75VR0

Entry ID Method Resolution Chain Position Source
AF-Q75VR0-F1 Predicted AlphaFoldDB

No variants for Q75VR0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q75VR0

No associated diseases with Q75VR0

3 regional properties for Q75VR0

Type Name Position InterPro Accession
domain EF-hand domain 329 - 401 IPR002048
domain Ion transport domain 127 - 313 IPR005821-1
domain Ion transport domain 434 - 680 IPR005821-2

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plant-type vacuole A closed structure that is completely surrounded by a unit membrane, contains liquid, and retains the same shape regardless of cell cycle phase. An example of this structure is found in Arabidopsis thaliana.
vacuolar membrane The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.

2 GO annotations of molecular function

Name Definition
calcium ion binding Binding to a calcium ion (Ca2+).
voltage-gated calcium channel activity Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.

3 GO annotations of biological process

Name Definition
calcium ion transport The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.
regulation of ion transmembrane transport Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEEYLLPGES SNSCRTRRRS GSIFDRRDAI AHGSAYQKAA ALVDLAEDGI GLPEEILEGA
70 80 90 100 110 120
SFEKAAELYF MFTRFDFLWS LNYLALVVLN FFEKPLWCSK HLAESCNNRD YYYLGELPFL
130 140 150 160 170 180
TGAESLIFEG VTLLLLIIHI LFPISYEGFN LYWRSLLNRL KVILLLILVA DIVVYILLPA
190 200 210 220 230 240
DFYYLPFRIA PYLRVVFFIL NIRELRDSFF ILAGMLGTYL NVVALSALFL LFSSWLAYVF
250 260 270 280 290 300
FEDTRQGKTT FTSYGTTLYQ MFVLFTTSNN PDVWIPAYKD SRWYCLFFVL YVLLGVYFVT
310 320 330 340 350 360
NLILAVVYDS FKSELVKQVA DKDRLRLRTL KKAFSLIDEA NNGLLNEKQC TLLFEELNKY
370 380 390 400 410 420
RTLPKISGDD FKSIFNELDD TGDFKINLEE FADLCSAIGL RFQKEDSLPI FEACPNFYHS
430 440 450 460 470 480
PASEKLRGFI RGATFEYIIV FVLLVNLVAV IIETTLDIQN NSGQTFWQKV EFTFGWLYVI
490 500 510 520 530 540
EMALKVYTYG FENYWRDGQN RFDFIVTWVI VIGETTTFVA PDDLTFLSNG EWIRYLLIAR
550 560 570 580 590 600
MLRLIRLLMH VERYRAFVAT FLTLIPSLMP YLGTIFCILC FYCSLGLQIF GGIVNTGNPN
610 620 630 640 650 660
LAQTDLAGND YLLFNFNDYP NGMVTLFNIL VMGNWQVWMQ SYKELTGTSW TYAYFVSFYL
670 680 690 700 710 720
ISVLWLLNLI VAFVLEAFQA EMDLEASARC VDGDDKEAKR ERRRNVGTKT RSQRVDFLLH
730
HMLRSELTEC SNDNP