Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q75LV5

Entry ID Method Resolution Chain Position Source
AF-Q75LV5-F1 Predicted AlphaFoldDB

No variants for Q75LV5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q75LV5

No associated diseases with Q75LV5

8 regional properties for Q75LV5

Type Name Position InterPro Accession
repeat WD40 repeat 149 - 197 IPR001680-1
repeat WD40 repeat 209 - 330 IPR001680-2
repeat WD40 repeat 334 - 371 IPR001680-3
repeat WD40 repeat 404 - 442 IPR001680-4
conserved_site WD40 repeat, conserved site 234 - 248 IPR019775
repeat G-protein beta WD-40 repeat 234 - 248 IPR020472-1
repeat G-protein beta WD-40 repeat 317 - 331 IPR020472-2
repeat G-protein beta WD-40 repeat 358 - 372 IPR020472-3

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
small-subunit processome A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.

2 GO annotations of molecular function

Name Definition
snoRNA binding Binding to a small nucleolar RNA.
U3 snoRNA binding Binding to a U3 small nucleolar RNA.

1 GO annotations of biological process

Name Definition
rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O43818 RRP9 U3 small nucleolar RNA-interacting protein 2 Homo sapiens (Human) PR
10 20 30 40 50 60
MAPRPRKRVS RPKPRATSRG RGGGDEDPFF ESEPKRRRGG GRDEDIESED SDLEGVAAAA
70 80 90 100 110 120
AGGVGDDGEE EEEEEEEQET AGEKKMRIAK ELLKKVTDAA RRRREDDEDE DEGEEAGRRR
130 140 150 160 170 180
VADILLKRQF EESGRKRMEL ADRILQPDPE DGFKMLVKHR QPVTAVVLSK DSDKGFSASK
190 200 210 220 230 240
DGVIVHWDVE TGKSEKYLWP SENVLVSHHA KPPLSAKRSK QVLALAVSAD GRYLASGGLD
250 260 270 280 290 300
RHIHLWDVRS REHIQAFSGH RGAISCLSFG PDSSELFSGS FDRKIMQWNA EDRTYMNCLF
310 320 330 340 350 360
GHQNEVLTMD ALSKDRLLTV ARDRTMHLWK IPEESQLLFR APATASLECC CFIDDKEFLT
370 380 390 400 410 420
GSDDGSVELW SIMRKKPTHI IRNAHPVFRN NLNSLENNVE ENGIHKPESV SSAQSWVSAI
430 440 450 460 470 480
AARRGSDLAA SGAANGSVRL WAIEPDSKGI RPLFSLRLDG FVNSLAIPKS GRFIVAGVGQ
490 500 510
EPRLGRWGRV RSAQNGVVIH PIRLKEESED L