Q75C70

PR
Gene name
NOP9 (ACR046W)
Protein name
Nucleolar protein 9
Names
Pumilio domain-containing protein NOP9
Species
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
KEGG Pathway
ago:AGOS_ACR046W
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-83 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q75C70

Entry ID Method Resolution Chain Position Source
AF-Q75C70-F1 Predicted AlphaFoldDB

No variants for Q75C70

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q75C70

No associated diseases with Q75C70

8 regional properties for Q75C70

Type Name Position InterPro Accession
repeat Pumilio RNA-binding repeat 91 - 126 IPR001313-1
repeat Pumilio RNA-binding repeat 127 - 163 IPR001313-2
repeat Pumilio RNA-binding repeat 189 - 224 IPR001313-3
repeat Pumilio RNA-binding repeat 290 - 325 IPR001313-4
repeat Pumilio RNA-binding repeat 338 - 373 IPR001313-5
repeat Pumilio RNA-binding repeat 375 - 411 IPR001313-6
repeat Pumilio RNA-binding repeat 516 - 553 IPR001313-7
repeat Pumilio RNA-binding repeat 554 - 591 IPR001313-8

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
90S preribosome A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
preribosome, small subunit precursor A preribosomal complex consisting of 20S pre-rRNA, ribosomal proteins including late-associating small subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic small ribosomal subunit.
small-subunit processome A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.

1 GO annotations of molecular function

Name Definition
RNA binding Binding to an RNA molecule or a portion thereof.

4 GO annotations of biological process

Name Definition
endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Endonucleolytic cleavage within the 5'-External Transcribed Spacer (ETS) of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. Endonucleolytic cleavage within the 5'-ETS of the pre-RNA is conserved as one of the early steps of rRNA processing in all eukaryotes, but the specific position of cleavage is variable.
endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript.
endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Endonucleolytic cleavage between the 5'-External Transcribed Spacer (5'-ETS) and the 5' end of the SSU-rRNA of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA.
ribosomal small subunit export from nucleus The directed movement of a ribosomal small subunit from the nucleus into the cytoplasm.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAKQRGRKLL QKQNKDDFKH SLDQERHEEE VIQVPVDKAP APISADGPNT FFGTLDTQEL
70 80 90 100 110 120
EYFKRAESTM AVDTFESADE KYQFINSVIE ESKGKELKLA TSQICSKLME RIILAADDQQ
130 140 150 160 170 180
LKAIFQGING FFVNLSYNKY ASHVVETLLV RSAALIEKEL LTPVFEAELD GDEQVYASME
190 200 210 220 230 240
NMFLFMLNEL KPHMKMMINH QYASHVFRLL ILVLSAKKLP KSTQSNSALR SKKSKIARKM
250 260 270 280 290 300
VDLKDNADFD RTYRTPDSFK LELKGILVML YKQFTNGIEP GTKHSEVNIA CVTKFREYCV
310 320 330 340 350 360
DKVASPVIQL IIQVEGIFDR DRSFWNLVFS NTEQNDPKEE SFMEYLLSDS VGSHFLQAVI
370 380 390 400 410 420
GFARTKQVER LYKLYMQDRI VKLAKRDTTG AFVIMSLLQN LGSKEVKSIL DDLVPELSIL
430 440 450 460 470 480
LNSNLDFGSE IIEASIRQGD YKKTEIVEQL GKKYYPADSE SKNILESCLQ LASSTLGNTK
490 500 510 520 530 540
DDWPTADERR RALFLEKLIN FDDYFLEIAV ESLLNLPEER IMQMCYHGVF SHVVEHVLQA
550 560 570 580 590 600
KRVETVKRKL LLNILYKDAV NLACNAYGSH IMDKLWEFTA KLTLYKERIA NLLLEEADKV
610 620 630 640 650 660
KNSIYGRQVW KNWHLELYVR KRFDWRKKVK EQELEVFPDS KPLQPKQKES IPAKRSAPSN
670
NQRPGSLNKK RNAEKHHT