Q75BY9
Gene name |
ATG5 (ACR131C) |
Protein name |
Autophagy protein 5 |
Names |
|
Species |
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) |
KEGG Pathway |
ago:AGOS_ACR131C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q75BY9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q75BY9-F1 | Predicted | AlphaFoldDB |
No variants for Q75BY9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q75BY9 | |||||
No associated diseases with Q75BY9
No regional properties for Q75BY9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q75BY9 | |||
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| Atg12-Atg5-Atg16 complex | A protein complex required for the expansion of the autophagosomal membrane. In budding yeast, this complex consists of Atg12p, Atg5p and Atg16p. |
| autophagosome | A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| phagophore | A disk-like structure that expands, rounds up into a cup-shaped structure, and eventually closes around its cargo (for example cytoplasmic components) to become an autophagosome or Cvt vesicle. |
| phagophore assembly site membrane | A cellular membrane associated with the phagophore assembly site. |
| vacuole-isolation membrane contact site | An organelle membrane contact site formed at the junction of the vacuolar membrane and the isolation membrane or phagophore in response to starvation or other stresses, leading to the formation of the autophagosome. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| Atg8 ligase activity | Catalysis of the covalent attachment of the ubiquitin-like protein Atg8 to substrate molecules; phosphatidylethanolamine is a known substrate. |
| cargo receptor ligand activity | The activity of a gene product that interacts with a cargo receptor and initiates endocytosis. |
| enzyme activator activity | Binds to and increases the activity of an enzyme. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| autophagosome assembly | The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm. |
| autophagy of mitochondrion | The autophagic process in which mitochondria are delivered to a type of vacuole and degraded in response to changing cellular conditions. |
| autophagy of nucleus | A form of autophagy, by which damaged or non-essential parts of the nucleus, or even an entire nucleus is degraded. |
| C-terminal protein lipidation | The covalent attachment of a lipid group to the carboxy-terminus of a protein. |
| cellular response to nitrogen starvation | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nitrogen. |
| cytoplasm to vacuole transport by the Cvt pathway | A cytoplasm to vacuole targeting pathway that uses machinery common with autophagy. The Cvt vesicle is formed when the receptor protein, Atg19, binds to the complexes of the target protein (aminopeptidase or alpha-mannosidase homododecamers), forming the Cvt complex. Atg11 binds to Atg9 and transports the Cvt complex to the pre-autophagosome (PAS). The phagophore membrane expands around the Cvt complex (excluding bulk cytoplasm) forming the Cvt vesicle. This pathway is mostly observed in yeast. |
| late nucleophagy | A type of nucleophagy, distinct from piecemeal microautophagy of the nucleus (PNM) where the nuclear material is delivered to the vacuole/lysosome for breakdown and recycling later than observed for PNM. |
| piecemeal microautophagy of the nucleus | Degradation of a cell nucleus by lysosomal microautophagy. |
| selective autophagy | The macroautophagy process in which specific structures are targeted by the autophagy process. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGVVNELRQR | TWSGMLNVEV | VLNPKLVVQG | MPDEQVRCHL | RIPRESYLVL | HLPFVLNKLR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GVLRQEVKDA | FHGWWFGMED | VLVHWNHPVG | TLYDSLVGLR | PQERAAQFQA | NTLTMWTLTL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NYSEDARDGS | VPLVGGMQQV | EDFWRHQWKQ | ACYIIHGSSK | QIMSLSIPDS | KTFWDCVLQR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DERVFRGIAS | RITARKGGVK | ALPVRIHQTT | LRELRTLQPT | VKPGEWGGGT | LGELLRAELP |
| 250 | 260 | 270 | 280 | 290 | |
| ECFKNGSVLR | PVVHGIEVSP | ESQLADLYHL | FCSFDGFLHI | SICSPVALII | PTT |