Q75BB3
Gene name |
LYS2 (ADL346W) |
Protein name |
L-2-aminoadipate reductase large subunit |
Names |
Alpha-aminoadipate reductase, Alpha-AR, L-aminoadipate-semialdehyde dehydrogenase |
Species |
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) |
KEGG Pathway |
ago:AGOS_ADL346W |
EC number |
1.2.1.31: With NAD(+) or NADP(+) as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q75BB3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q75BB3-F1 | Predicted | AlphaFoldDB |
No variants for Q75BB3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q75BB3 | |||||
No associated diseases with Q75BB3
7 regional properties for Q75BB3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | AMP-dependent synthetase/ligase domain | 243 - 705 | IPR000873 |
| domain | Phosphopantetheine binding ACP domain | 843 - 920 | IPR009081 |
| domain | Amino acid adenylation domain | 270 - 728 | IPR010071 |
| domain | Thioester reductase-like domain | 969 - 1349 | IPR010080 |
| domain | Fatty acyl-coenzyme A reductase, NAD-binding domain | 972 - 1221 | IPR013120 |
| domain | Polyketide synthase, phosphopantetheine-binding domain | 849 - 920 | IPR020806 |
| conserved_site | AMP-binding, conserved site | 418 - 429 | IPR020845 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.2.1.31 | With NAD(+) or NADP(+) as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| L-aminoadipate-semialdehyde dehydrogenase activity | Catalysis of the reaction: L-2-aminoadipate 6-semialdehyde + NADP+ + H2O = L-2-aminoadipate + NADPH + H+. |
| phosphopantetheine binding | Binding to phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate). |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| lysine biosynthetic process via aminoadipic acid | The chemical reactions and pathways resulting in the formation of lysine by the aminoadipic pathway. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MCAVLEPSMI | RWLSEVDNIV | VSSLPSDYIP | SGPAGVKAES | CEVELPGSFG | VIDEEDSYIR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LLSAFATLVC | RMSGESDVAM | YSKANRLLKL | AVPPGVAFQQ | LRASVTEAVE | GTLALPAVDF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DELSALEREK | KQLDYYPQYF | KVGVVTAADK | TKLDQFRYHK | FELLLRQVTS | SRFEMVYDSE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RFSPDRIGEL | GEQLVQFLTL | VEAKDDADVY | AISLVTSGAS | RVLPDPTTDL | GWGQFRGAIH |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DIFQHHAETR | PDRLCVVETG | VGQVAARTFT | YSAINCASNI | VAHYLLARGI | RRGDVVMIYS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TRGVDLLVSV | LGVLKSGAVF | SVIDPAYPPA | RQNVYLGVAK | PAGLIVIQAA | GQLDEAVEAF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| IRDNLSLKAR | LPALALQTDG | AILGGTLPDF | HLDTLVPFAS | LKNTRTDVVV | GPDSNPTLSF |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TSGSEGIPKG | VLGRHFSLTY | YFDWMAKRFG | LSEDDKFTML | SGIAHDPIQR | DMFTPIYLGA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| QLLVPQEDDI | GTPGRLATWM | ATHGATVTHL | TPAMGQVLTA | DATTPFPSLK | RAFFVGDVLT |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KRDCARLQSL | AENVAIVNMY | GSTETQRAVS | YFEVPSCSSN | PSYLDNLKSI | IPAGRGMHNV |
| 610 | 620 | 630 | 640 | 650 | 660 |
| QLLIVNRHDR | TKLCGIGEVG | EIYVRAGGLS | EGYRGLPEIN | KEKFIDNWFV | DAGHWGGLDL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| SGDEPWRNYW | LGVRDRLYRT | GDLGRYLPNG | DCECCGRADD | QVKIRGFRIE | LGEIDTNISQ |
| 730 | 740 | 750 | 760 | 770 | 780 |
| YPLCRENITL | LRKDQNGEST | LISYLVPRSD | QKALASFISA | VPESIATESI | AGSLIKYHKL |
| 790 | 800 | 810 | 820 | 830 | 840 |
| INDIRGFLKK | RLAGYAIPTL | IMVMERLPLN | PNGKIDKNKL | QFPEPTELDR | ASEHFASETL |
| 850 | 860 | 870 | 880 | 890 | 900 |
| GLSSFSPLEQ | EIRKIWLDLL | PTRPAITSSD | ESFFDLGGTS | ILATRMAIVL | RNRLNISLAL |
| 910 | 920 | 930 | 940 | 950 | 960 |
| STIFRYPTVK | ELAKEISRVR | GTISDDKSSN | SGTTEYYADA | KHVSEAELAS | KYESRLSLLP |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| SGATSAPVYV | FLTGVTGFLG | CHILADLLNR | SRKPYDITVY | AHVRASDESS | ALQRIKSVCT |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| AYGLWKNAYA | PRIKVVLGNL | AEKQFGLPKK | AWHDLQEGID | VIIHNAALVH | WVYPYSKLRE |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| ANVLSTVNVL | NLAAAGKAKY | FTFVSSTSAL | DTKHYLELSN | AAIESGGSGV | PEDDDLMGGS |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| LGLKGGYGQS | KWAAEFIIKR | AGERGLRGCI | LRPGYVTGSP | STGASNADDF | LLRFLRGCVQ |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| LGKIPDIEGT | VNMVPVDYVA | RLATAASFSS | SGNTHMMVVN | VNAKPRISFR | DYLLALKEYG |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| YQVTSVPYDE | WSKALESSSD | EENPLYPLLY | LVLDDLPKKL | RSPELDTTNA | KFVLEEDFAR |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| TNIEPIIITS | VSLEVVGSYI | SFLHKLGFLE | EPAKGSRPLP | NISLSDEQIS | LIAAVATARS |
| STAKP |