Q75BA8

PR
Gene name
MED1 (ADL341C)
Protein name
Mediator of RNA polymerase II transcription subunit 1
Names
Mediator complex subunit 1
Species
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
KEGG Pathway
ago:AGOS_ADL341C
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

295-385 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q75BA8

Entry ID Method Resolution Chain Position Source
AF-Q75BA8-F1 Predicted AlphaFoldDB

No variants for Q75BA8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q75BA8

No associated diseases with Q75BA8

1 regional properties for Q75BA8

Type Name Position InterPro Accession
domain Mediator complex, subunit Med1 11 - 141 IPR019680

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
core mediator complex A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.
mediator complex A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.

1 GO annotations of molecular function

Name Definition
transcription coregulator activity A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.

4 GO annotations of biological process

Name Definition
negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
positive regulation of transcription elongation by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II.
positive regulation of transcription initiation by RNA polymerase II Any process that increases the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter.
RNA polymerase II preinitiation complex assembly The aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPDAYVESLG KMIAILVNYK PGSITLENIT RLCQTMGLES FVDQVSANIS RLSIASKIIV
70 80 90 100 110 120
IDIDYEVTDG KVIDVKLVLA SNFDKFDYFN GEANILHRSL TTYSDLHEFH HNLKFLTLLD
130 140 150 160 170 180
ACSSIDIESN VSQFDLFEYY SMLPQYMQSY LDDNGAQLTV QTNLNDRFGI YLLDHSEKKV
190 200 210 220 230 240
AKLTFAATQD PNQRYYEYKY SSETKEWINQ SAESYTTGIT LVFELLGDPP TYLPKDSLPP
250 260 270 280 290 300
EHPDEGFTSA SASELQRRFA FKCQNPRVTL VNDFTVDVYP ASTFQLLNDN ICLCFDILRR
310 320 330 340 350 360
QKWWHTVLYP ISQLLLHQGQ DSAVGDAPAP AAQPPLHRRR SSNKGCRRAS AAESATLGDE
370 380 390 400 410 420
NMHQLTLTEI MNKSVIPEDD AMMDDRIELY VNENYVYLGT QEGCSFYNDP IERWEAFVES
LRQMLT