Q75AL4

PR
Gene name
CBR1 (ADL087W)
Protein name
NADH-cytochrome b5 reductase 1
Names
Microsomal cytochrome b reductase
Species
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
KEGG Pathway
ago:AGOS_ADL087W
EC number
1.6.2.2: With a heme protein as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-69 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q75AL4

Entry ID Method Resolution Chain Position Source
AF-Q75AL4-F1 Predicted AlphaFoldDB

No variants for Q75AL4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q75AL4

No associated diseases with Q75AL4

8 regional properties for Q75AL4

Type Name Position InterPro Accession
domain Oxidoreductase FAD/NAD(P)-binding 154 - 263 IPR001433
domain Flavoprotein pyridine nucleotide cytochrome reductase 93 - 100 IPR001709-1
domain Flavoprotein pyridine nucleotide cytochrome reductase 153 - 172 IPR001709-2
domain Flavoprotein pyridine nucleotide cytochrome reductase 179 - 188 IPR001709-3
domain Flavoprotein pyridine nucleotide cytochrome reductase 191 - 202 IPR001709-4
domain Flavoprotein pyridine nucleotide cytochrome reductase 249 - 257 IPR001709-5
domain Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain 46 - 144 IPR008333
domain FAD-binding domain, ferredoxin reductase-type 41 - 145 IPR017927

Functions

Description
EC Number 1.6.2.2 With a heme protein as acceptor
Subcellular Localization
  • Mitochondrion outer membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrial outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
cytochrome-b5 reductase activity, acting on NAD(P)H Catalysis of the reaction: NAD(P)H + H+ + 2 ferricytochrome b(5) = NAD(P)+ + 2 ferrocytochrome b(5).
NADH dehydrogenase activity Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor.

2 GO annotations of biological process

Name Definition
peptidyl-diphthamide biosynthetic process from peptidyl-histidine The modification of peptidyl-histidine to 2'-(3-carboxamido-3-(trimethylammonio)propyl)-L-histidine, known as diphthamide, found in translation elongation factor EF-2. The process occurs in eukaryotes and archaea but not eubacteria.
tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation The process whereby a wobble base uridine residue in a tRNA is modified to 5-methoxycarbonylmethyl-2-thiouridine.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDYKFEALVT ALVLAVSFIF IYGKFSGAKQ SQPAVKTTLN KDWQEFSLLT KTVLTHNTAI
70 80 90 100 110 120
YRFGLPEADA VLGLPIGQHI SISGVIDGKE MLRSYTPTSL DSDATGYFEL LVKSYEKGNI
130 140 150 160 170 180
SKMLAELAIG DRIKVRGPKG FYHYEPNMYK EIGMIAGGTG ISPMYQIIRA IFSNPRDKTR
190 200 210 220 230 240
VCLVYGNQTK DDILLKPELD AMVAAKPDQF KILYMLDKVA EGEQWEGKLG YITEAIMREH
250 260 270 280
LPAPSSSAQL LLCGPPPMVS SAKRIAVSLG FEKAKPISKK GDQVFAF