Q75A83
PR
Gene name |
MRD1 (ADR035C) |
Protein name |
Multiple RNA-binding domain-containing protein 1 |
Names |
|
Species |
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) |
KEGG Pathway |
ago:AGOS_ADR035C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q75A83
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q75A83-F1 | Predicted | AlphaFoldDB |
No variants for Q75A83
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q75A83 | |||||
No associated diseases with Q75A83
8 regional properties for Q75A83
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | RNA recognition motif domain | 2 - 88 | IPR000504-1 |
| domain | RNA recognition motif domain | 301 - 379 | IPR000504-2 |
| domain | RNA recognition motif domain | 488 - 560 | IPR000504-3 |
| domain | RNA recognition motif domain | 612 - 695 | IPR000504-4 |
| domain | RNA recognition motif domain | 712 - 789 | IPR000504-5 |
| domain | RNA recognition motif domain, eukaryote | 302 - 375 | IPR003954-1 |
| domain | RNA recognition motif domain, eukaryote | 713 - 785 | IPR003954-2 |
| domain | Mrd1, RNA recognition motif 3 | 490 - 559 | IPR034482 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| 90S preribosome | A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins. |
| nuclear speck | A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| small-subunit processome | A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| rRNA primary transcript binding | Binding to an unprocessed ribosomal RNA transcript. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Endonucleolytic cleavage within the 5'-External Transcribed Spacer (ETS) of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. Endonucleolytic cleavage within the 5'-ETS of the pre-RNA is conserved as one of the early steps of rRNA processing in all eukaryotes, but the specific position of cleavage is variable. |
| endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. |
| endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Endonucleolytic cleavage between the 5'-External Transcribed Spacer (5'-ETS) and the 5' end of the SSU-rRNA of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA. |
| mRNA splicing, via spliceosome | The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. |
| small-subunit processome assembly | The aggregation, arrangement and bonding together of proteins and RNA molecules to form a small-subunit processome. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSRVIVKGLP | IYLEEARLRA | HFLKRLQQQG | RGSEDQITDV | KIVKDKSGNS | RRFAFIGYRS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EQDAFDAIEY | FNGSFIDTAR | IEVAMAKSFA | DPRVPTPMRE | KRREALKRLR | EREDRILAEK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RQKQTKPQHG | IDAEISKNKQ | LQEFIETMNP | KMAAAAANPM | ARAAEQPASA | NPLLSALHGA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EDDEEVDMFQ | LSEQESDDEY | TDLHQRPQSA | EEDELEEPAV | GQDLDAAPAP | DAAEDGMATN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QEVSDLEWLK | NRRIRIRDGE | DAEAAPAPQE | QAAEEPAEQE | VPQEDEVSAE | EAALTKIRAT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GRLFLRNILY | DATEEDFKQL | FSPYGELEEV | HVAVDTRTGQ | SKGFAYVLFK | DPEHAANAYI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ELDKQIFQGR | LLHILPADAK | KTHRLDEFDL | KNLPLKKQRE | LKRKATAAQQ | TFSWNSLFMN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QDAVLSSVAA | KLGMEKSQLI | DPENSGSAVK | QALAEAHVIG | DVRKYFEARG | VDLTQFEKFK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KVTERDDRII | LVKNFPHGTT | REELAELFLP | FGKIERLLMP | PSGTIAIIQY | RDVPAARGAF |
| 550 | 560 | 570 | 580 | 590 | 600 |
| TKLSYKRFKE | AILYLEKGPK | DCFSREPRGD | ELLEGDAAPE | DVKEIKKSVE | DVMDADSKTP |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SSEATAIDGP | TVSIFVKNLN | FSTTSAQLAE | KFKPFSGFVV | AQVKTKPDPK | NSDKKLSMGF |
| 670 | 680 | 690 | 700 | 710 | 720 |
| GFIEFRTKEQ | AGAVIAAMDG | AVIDGHKIQL | KISHKQSSLP | KTSKGSKKKI | SGKIIVKNLP |
| 730 | 740 | 750 | 760 | 770 | 780 |
| FEATRKDVFE | LFSSFGQLKS | VRVPKKFDKS | ARGFAFVEFL | LPSEAENAMD | QLQGVHLLGR |
| 790 | 800 | 810 | 820 | 830 | |
| RLVMQYAEQE | SDDVEEQISK | MTMKMKKQAA | VSKMGALRNS | GKRKIDMSDD | ENDGLNGF |