Q75A48

PR
Gene name
ATG9 (ADR071W)
Protein name
Autophagy-related protein 9
Names
Species
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
KEGG Pathway
ago:AGOS_ADR071W
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

2-254 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q75A48

Entry ID Method Resolution Chain Position Source
AF-Q75A48-F1 Predicted AlphaFoldDB

No variants for Q75A48

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q75A48

No associated diseases with Q75A48

No regional properties for Q75A48

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q75A48

Functions

Description
EC Number
Subcellular Localization
  • Preautophagosomal structure membrane ; Multi-pass membrane protein
  • Cytoplasmic vesicle membrane ; Multi-pass membrane protein
  • Golgi apparatus membrane ; Multi-pass membrane protein
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

9 GO annotations of cellular component

Name Definition
autophagosome A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy.
cytoplasmic vesicle membrane The lipid bilayer surrounding a cytoplasmic vesicle.
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
phagophore A disk-like structure that expands, rounds up into a cup-shaped structure, and eventually closes around its cargo (for example cytoplasmic components) to become an autophagosome or Cvt vesicle.
phagophore assembly site Punctate structures proximal to the endoplasmic reticulum which are the sites where the Atg machinery assembles upon autophagy induction.
phagophore assembly site membrane A cellular membrane associated with the phagophore assembly site.

1 GO annotations of molecular function

Name Definition
phospholipid scramblase activity Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, by an ATP-independent mechanism.

6 GO annotations of biological process

Name Definition
autophagy of mitochondrion The autophagic process in which mitochondria are delivered to a type of vacuole and degraded in response to changing cellular conditions.
cytoplasm to vacuole transport by the Cvt pathway A cytoplasm to vacuole targeting pathway that uses machinery common with autophagy. The Cvt vesicle is formed when the receptor protein, Atg19, binds to the complexes of the target protein (aminopeptidase or alpha-mannosidase homododecamers), forming the Cvt complex. Atg11 binds to Atg9 and transports the Cvt complex to the pre-autophagosome (PAS). The phagophore membrane expands around the Cvt complex (excluding bulk cytoplasm) forming the Cvt vesicle. This pathway is mostly observed in yeast.
late nucleophagy A type of nucleophagy, distinct from piecemeal microautophagy of the nucleus (PNM) where the nuclear material is delivered to the vacuole/lysosome for breakdown and recycling later than observed for PNM.
piecemeal microautophagy of the nucleus Degradation of a cell nucleus by lysosomal microautophagy.
protein localization to phagophore assembly site Any process in which a protein is transported to, or maintained at, the phagophore assembly site (PAS).
reticulophagy The selective autohagy process in which parts of the endoplasmic reticulum are loaded into autophagosomes, delivered to the vacuole, and degraded in response to changing cellular conditions.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEQSEDTIQH ERKNTFLSRV FGVHSSEVGD SIETAELSQY PIQIARSGSN AIDESRVIES
70 80 90 100 110 120
DQASSSEEED TDGHDLSVAE NMTSYNGAQG SGSEDSDVPF SDQELETIET YTIAKVGQGS
130 140 150 160 170 180
SSEDDRLQAD SAEEEDALLF QHRLQDGSKG RNKVSSQPLG LKRILGSKGK SILGKEPASQ
190 200 210 220 230 240
EDSFIFRKGP TWDEENQLRP ESKRPGLLSG KSNARLSSPS RPSPLSARER ALWKWANVEN
250 260 270 280 290 300
LDGFLQDVYS YYLGNGFYCI MIEKILNLLT LLFIVFISTY MSHCIDYSKL PNGHKFSDVR
310 320 330 340 350 360
VDQCYETQIT GTTKLLFWIF GVFVVLKVVQ MYFDFRRIHE IHNFYTYLLN ISDKELQTIP
370 380 390 400 410 420
WQSVIHQIMR LKDQNAVTAN VVEVKAKNHI DAHDVANRIM RKENYLIALY NKDILHLSLP
430 440 450 460 470 480
IPLYRTSTLT KTLEWNIHLC IIGFAFNEAG FLKQSFLNPA QREFLSEELK KRFILAGFLN
490 500 510 520 530 540
IILAPFLVVY FVLLYFFRYF NEYKTSPGSL STRQYTPIAE WKFREYNELY HLFKKRMGLS
550 560 570 580 590 600
YEVANTYINQ FPNALGDYFF KFVKFISGSF VAILALMTVL DPENFLNFEL TADRTVLFYM
610 620 630 640 650 660
TVLGTIWAVC HSAVNDNCSV FDPEDSLKEL ITYIHYAPKE WDGRYHTDEV KQEFCKLYNL
670 680 690 700 710 720
RVILLLRELA SLIMTPFILW FSLPNSAESI VDFFREVTVY GDGLGYVCKY AMFDENCKKG
730 740 750 760 770 780
LRTNKHLQGT QTKYGHSLGD DHDSSDEETD KGMNKMIQSY MYFVDDYQNS VNAVGKYQIP
790 800 810 820 830 840
KTQNLSHESK YNMKSHQHYS WKKQFKLGSK PEDFKIGSVT PRALSSSILA NKPKSNLRAR
850 860 870 880 890
LDPEISHSNV QFDDLGESFI NSIPVADYDP IERSDAMGGN GVLGLLNQYY RKSDVGR