Q75A43
PR
Gene name |
TUB4 (ADR076C) |
Protein name |
Tubulin gamma chain |
Names |
Gamma-tubulin |
Species |
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) |
KEGG Pathway |
ago:AGOS_ADR076C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q75A43
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q75A43-F1 | Predicted | AlphaFoldDB |
No variants for Q75A43
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q75A43 | |||||
No associated diseases with Q75A43
4 regional properties for Q75A43
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Tubby, C-terminal | 129 - 428 | IPR000007 |
| domain | F-box domain | 68 - 114 | IPR001810 |
| conserved_site | Tubby, C-terminal, conserved site | 356 - 369 | IPR018066-1 |
| conserved_site | Tubby, C-terminal, conserved site | 413 - 428 | IPR018066-2 |
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| gamma-tubulin complex | A multiprotein complex composed of gamma-tubulin and other non-tubulin proteins. Gamma-tubulin complexes are localized to microtubule organizing centers, and play an important role in the nucleation of microtubules. The number and complexity of non-tubulin proteins associated with these complexes varies between species. |
| gamma-tubulin small complex | A complex usually comprising two gamma-tubulin molecules and two conserved non-tubulin proteins. Some gamma-tubulin small complexes are thought to be the repeating unit making up the core of the gamma-tubulin ring complex. |
| inner plaque of spindle pole body | One of three laminate structures that form the spindle pole body; the inner plaque is in the nucleus. |
| microtubule | Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| outer plaque of spindle pole body | One of three laminate structures that form the spindle pole body; the outer plaque is in the cytoplasm. |
| spindle | The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTP binding | Binding to GTP, guanosine triphosphate. |
| structural constituent of cytoskeleton | The action of a molecule that contributes to the structural integrity of a cytoskeletal structure. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| cytoplasmic microtubule organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell. |
| meiotic spindle organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a meiotic cell cycle. |
| microtubule cytoskeleton organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. |
| microtubule nucleation | The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation). |
| microtubule nucleation by spindle pole body | The 'de novo' formation of a microtubule, mediated by the spindle pole body. |
| mitotic cell cycle | Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent. |
| mitotic sister chromatid segregation | The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets. |
| mitotic spindle organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle. |
| positive regulation of cytoplasmic translation | Any process that activates or increases the frequency, rate or extent of cytoplasmic translation. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTGEIISIQV | GQCGNQVGKQ | FWGQLAREHG | IGVDGQSLHP | EDANVVREDD | TNVFFRQNDH |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NRFTPRALLY | DLEPSAIGDV | QNCFPGFFNE | RNVWISKEEL | GAGNTWSIGY | DYGLEKQDEF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| MNMIDKEIDA | TGNFEGFQLI | HSVAGGTGSG | LGSNLLEALS | DRYHKKIVST | YSVFPSRESE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VVVQPYNTIL | TLRRLIDNSD | ASVLFDNDAL | LNLTARVLRD | SNTSYQQTNQ | LIASVMSSVT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NSLRFPSYMY | NSLPSIFSTL | VPTPELHFLA | PSFTPFTSDF | VPGAKDFKRL | SAYDVILDLF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DKNNSMVTRD | TDTPVYLAIY | DALQGAVEQS | DVTRAILKTQ | QRIKFAPWSP | TSLHVNLGRK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SPYNSSANSD | YVSGMMLANT | SSIVSVFQKT | VSSFDVIFKR | GAFLHKFQNG | KMFQHGWDEF |
| 430 | 440 | 450 | 460 | ||
| LESREVIQGV | IDEYIAAEQE | NYLDDVLEED | GNFVGGDAEM | IDIESNDDII |