Q759V4
PR
Gene name |
MSH3 (ADR168C) |
Protein name |
DNA mismatch repair protein MSH3 |
Names |
MutS protein homolog 3 |
Species |
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) |
KEGG Pathway |
ago:AGOS_ADR168C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q759V4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q759V4-F1 | Predicted | AlphaFoldDB |
No variants for Q759V4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q759V4 | |||||
No associated diseases with Q759V4
4 regional properties for Q759V4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | DNA mismatch repair protein MutS, C-terminal | 789 - 984 | IPR000432 |
| domain | DNA mismatch repair protein MutS-like, N-terminal | 142 - 265 | IPR007695 |
| domain | DNA mismatch repair protein MutS, core | 426 - 773 | IPR007696 |
| domain | DNA mismatch repair protein MutS, connector domain | 297 - 372 | IPR007860 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| MutSbeta complex | A heterodimer involved in binding to and correcting insertion/deletion mutations. In human the complex consists of two subunits, MSH2 and MSH3. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP-dependent DNA damage sensor activity | A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis. |
| double-strand/single-strand DNA junction binding | Binding to a DNA segment that contains double-stranded DNA flanked by a region of single-stranded DNA. |
| double-stranded DNA binding | Binding to double-stranded DNA. |
| heteroduplex DNA loop binding | Binding to a DNA segment containing a loop. A loop occurs when DNA contains a large insertion or deletion that causes a region of unpaired single-stranded DNA to loop out, while the rest of the DNA is in a paired double-stranded configuration. |
| Y-form DNA binding | Binding to a DNA segment shaped like a Y. This shape occurs when DNA contains a region of paired double-stranded DNA on one end and a region of unpaired DNA strands on the opposite end. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| meiotic mismatch repair | A system for the identification and correction of base-base mismatches, small insertion-deletion loops, and regions of heterology that are present in duplex DNA formed with strands from two recombining molecules. Correction of the mismatch can result in non-Mendelian segregation of alleles following meiosis. |
| mismatch repair | A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. |
| mitotic recombination | The exchange, reciprocal or nonreciprocal, of genetic material between one DNA molecule and a homologous DNA region that occurs during mitotic cell cycles. |
| removal of nonhomologous ends | The removal of nonhomologous sequences at the broken 3' single-strand DNA end before DNA repair synthesis can occur. |
| replication fork arrest | Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication by impeding the progress of the DNA replication fork. Replication fork arrest is one of the 'quality control' processes ensuring that DNA-dependent DNA replication occurs correctly. DNA replication fork arrest during DNA-dependent DNA replication is not known to occur outside of cases where a replication error needs to be prevented or corrected. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLQQPTISRF | FKSSSTRKKS | EQRTAKEEAE | LMQLLESDGE | NNSATVPSDR | KPEAAPMHVG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LGNKAAAGGA | VPGQVKSATR | GFEDFRFNRR | REACGKEQEV | GFAERLQRIM | ERREGGCVEE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DETELDNEAP | RSKRAKPNRL | TELDQQFKDL | KLQHMDKVLA | VRVGYKYKFF | AEDAVMVSRV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LQIKLVPGKL | TVHETDPADH | KHKKFAYCTI | PDTRLEVHLQ | RLMHHNLKVG | VVEQTETSAV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KKNSGTSSSV | FSREVTNIFT | RATYGINETF | GTKDRRVLGD | SASVWGLVCK | RQPSYTRYFL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VSVNLNSGEV | IFDDFKEERF | LTEALETRIK | YTNPSEVVVG | DGLGSEIEKV | FHTSDSDITL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NRIELVGLYE | EIFSEPHPAF | KGNVPLQTAL | MLVHGYLTNF | KNESLLFFKE | NFKPFCSKTH |
| 430 | 440 | 450 | 460 | 470 | 480 |
| MILPSSAIES | LDIFENSTDR | SSKGSLLWVL | DHTRTNYGLR | NLKNWIAKPL | INIDQIQQRL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| DAVQCISTEV | GNIFIESLNN | MLRDGQDLER | ILNRIAYGKT | SRREVYLFLR | ELTQLATLFS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SHHRYIETNV | LSANGKIRMQ | SSLLANIFTD | LDEYWKQFPI | PNFLAMINID | AALDKNPDRP |
| 610 | 620 | 630 | 640 | 650 | 660 |
| YVEYFNLTKY | DRAEPLISKQ | QDIEAVIGEL | RDELKNIRVI | LKRPMLNYKD | EIDFLVEIRN |
| 670 | 680 | 690 | 700 | 710 | 720 |
| TQVSSVPVDW | VKVASTKAVS | RFQTPGTAKL | VAKLQYHKEL | LQDLALQEYE | SFIKRITGEY |
| 730 | 740 | 750 | 760 | 770 | 780 |
| TSLRKAILHL | STYDCILSLA | ATSCNVDYVR | PKFNTAPQCI | NVINGRNPII | ESLDVRYMPN |
| 790 | 800 | 810 | 820 | 830 | 840 |
| DVNLNREGKK | IMIITGPNMG | GKSSYIRQVA | LLVIMAQIGC | YVPAQEAEFS | IFDQIFTRIG |
| 850 | 860 | 870 | 880 | 890 | 900 |
| AYDNLLRNDS | TFKIEMTEMV | QILRSSTENS | LLLLDEVGRG | TGTHDGISIS | YALLRYFIEL |
| 910 | 920 | 930 | 940 | 950 | 960 |
| HNACPLILFI | THYASLGSIR | SPILGNYHMS | YIEEKRPGEN | WPSVVFLYKL | KEGRAHNSYG |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| LNVAKLADIQ | TGIINRAYKI | STMLKQEMES | NSSIAAICTI | KHALAGNSAA | SLKSAIETLI |
| 1030 | |||||
| ESADHEQFVL | NM |