Q757L1

PR
Gene name
NTH2 (AER001C)
Protein name
Probable trehalase
Names
Alpha,alpha-trehalase, Alpha,alpha-trehalose glucohydrolase
Species
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
KEGG Pathway
ago:AGOS_AER001C
EC number
3.2.1.28: Glycosidases, ie enzymes hydrolyzing O- and S-glycosyl compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-151 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q757L1

Entry ID Method Resolution Chain Position Source
AF-Q757L1-F1 Predicted AlphaFoldDB

No variants for Q757L1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q757L1

No associated diseases with Q757L1

3 regional properties for Q757L1

Type Name Position InterPro Accession
domain Neutral trehalase Ca2+ binding 93 - 122 IPR011120
conserved_site Glycoside hydrolase, family 37, conserved site 286 - 299 IPR018232-1
conserved_site Glycoside hydrolase, family 37, conserved site 609 - 618 IPR018232-2

Functions

Description
EC Number 3.2.1.28 Glycosidases, ie enzymes hydrolyzing O- and S-glycosyl compounds
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) A protein complex that possesses alpha,alpha-trehalose-phosphate synthase (UDP-forming) and trehalose-phosphatase activities, and thus catalyzes two reactions in trehalose biosynthesis. In the complex identified in Saccharomyces, Tps1p has alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity, Tps2p has trehalose 6-phosphate phosphatase activity; Tps3p is a regulatory subunit, and an additional subunit, Tsl1p, may be present.

2 GO annotations of molecular function

Name Definition
alpha,alpha-trehalase activity Catalysis of the reaction: alpha,alpha-trehalose + H2O = 2 D-glucose.
calcium ion binding Binding to a calcium ion (Ca2+).

2 GO annotations of biological process

Name Definition
ascospore formation The process in which cells that are products of meiosis acquire the specialized features of ascospores. Ascospores are generally found in clusters of four or eight spores within a single mother cell, the ascus, and are characteristic of the ascomycete fungi (phylum Ascomycota).
trehalose catabolic process The chemical reactions and pathways resulting in the breakdown of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLQGMPKRSG SISELHDPFS SPDVYYGPAT DPRRQKQPNK YSRTRTMSII ENVSTFKSAG
70 80 90 100 110 120
KQYNIRRRGS EDDSMLASSG HRKFYIKDVD KTLEELLESE DTDGNYQITI EDRGPKTLRV
130 140 150 160 170 180
GTANSNGFRH VQIRGTYMLS NLLQELTIAK NFGRKQVILD EARLNEDPVN RLTRLITHQF
190 200 210 220 230 240
WDSLTRRIDY NSIAAIAADT KVDTPGAKVP RIYVPHGCPE QYEYFIECSQ LNPSLNLEVK
250 260 270 280 290 300
YLPDVITPEH VQSLNESPGL LALAMESHRD PITGESTLVG FPYVVPGGRF NELYGWDSYL
310 320 330 340 350 360
MALGLLDCNK VDIARGMVEH FIFEIEHYGK ILNANRSYYL CRSQPPFLTD MALKVFEKFG
370 380 390 400 410 420
GDQNPTAVDF LKRAFIAAIK EYKSVWMAEP RYDKTTGLSC YHPDGIGFPP ETEPDHFDAI
430 440 450 460 470 480
CRKFAEKHNV TIPEFRCMYD AGEVHEPELD EFFLHDRAVR ESGHDTSYRL ENVCAYLATI
490 500 510 520 530 540
DLNSLLYKYE KDIAYVVSKY FDDSITDYAG ETTTSSHWEA LADIRKQRIT KYLWDEETGF
550 560 570 580 590 600
FYDYNVHIGK RTSYDSATTF WAMWAGLATQ EQANAMVEKA LPRLEMLGGL VACTEESRGE
610 620 630 640 650 660
ITMNRPSRQW DYPYGWAPHQ MLAWTGLDNY GFTGVARRLA YRWLFLMTKA FVDYNGIVVE
670 680 690 700 710 720
KYDVTRGTDP HRVDAEYGNQ GADFKGVATE GFGWVNSSYI LGLKFMNTYA KRALANCTVP
730
DIFFKHMKPE EKARYALI