Q757E3

PR
Gene name
DUS3 (AER070C)
Protein name
tRNA-dihydrouridine(47) synthase [NAD(P)(+)]
Names
mRNA-dihydrouridine synthase DUS3, tRNA-dihydrouridine synthase 3
Species
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
KEGG Pathway
ago:AGOS_AER070C
EC number
1.3.1.89: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

23-105 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q757E3

Entry ID Method Resolution Chain Position Source
AF-Q757E3-F1 Predicted AlphaFoldDB

No variants for Q757E3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q757E3

No associated diseases with Q757E3

1 regional properties for Q757E3

Type Name Position InterPro Accession
domain Transcription initiation factor Rrn7, Zinc-finger 12 - 37 IPR021752

Functions

Description
EC Number 1.3.1.89 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nuclear periphery The portion of the nuclear lumen proximal to the inner nuclear membrane.

4 GO annotations of molecular function

Name Definition
flavin adenine dinucleotide binding Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
metal ion binding Binding to a metal ion.
tRNA dihydrouridine synthase activity Catalysis of the reaction: tRNA-uracil + acceptor = tRNA-dihydrouridine + reduced acceptor.
tRNA-dihydrouridine47 synthase activity Catalysis of the reaction: a 5,6-dihydrouracil47 in tRNA + NAD(P) <=> H+ + a uracil47 in tRNA + NAD(P)H.

1 GO annotations of biological process

Name Definition
mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSSTEGGAKR VAEDGSEVSE AKRVGRIEGV AQLKPEYVVA GAAQLRAAES DEELTSERMV
70 80 90 100 110 120
EPEGGTRKKS KKARGQNKNR DNRQAKEEHQ LCPRLAQGNA DACAFGAQCR YLHDVRTYLE
130 140 150 160 170 180
HKTAEIECPQ FTGCPVFAAT GRCPMGFKCR FLSSHCNMET LELATTPEDE RAKLWSVNHE
190 200 210 220 230 240
VNHIASDRKL DLVKRRAPFP RSEHVLEIID AIQQEFRDEM QGAAAAPEGA VAEVPQVQQR
250 260 270 280 290 300
EEQLSNKRAR QRELYAQYHE TRYFAQEKKP LDLHHKKIVS PLTTVGNLPF RRLMRQLGAD
310 320 330 340 350 360
VTYSEMALAV PLIQGTNSEW ALPKAHCSEL PGFGVQLACS KPWQAAKAAE ALADNVGDGL
370 380 390 400 410 420
SEINLNSGCP IDLLYRQGSG SALLDNPARM IRCLNAMNYV SKDVPVSVKL RTGTRDGHPI
430 440 450 460 470 480
ALGLCKRLVM ETDVAAITLH GRTRQQRYTR SADWDYVGQV ADALRSYETE RAEKLKDREG
490 500 510 520 530 540
KLRIQFVGNG DCNNWEDWYR HLENENVDSV MVARGALIKP WIFEEVDARQ YIDKSSSERL
550 560 570 580 590 600
EILRDYARFS MDHWGTDEYG IALCRRYFCE FMSFFHRYVP MGICERYPVL LNERPPNWRG
610 620 630 640
RDDLETLLGS TDAADWIKLS EQFFGPTPDK FVFQPKHKSN SYAPSVQ