Q754U8
Gene name |
PRP5 (AFL027C) |
Protein name |
Pre-mRNA-processing ATP-dependent RNA helicase PRP5 |
Names |
|
Species |
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) |
KEGG Pathway |
ago:AGOS_AFL027C |
EC number |
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q754U8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q754U8-F1 | Predicted | AlphaFoldDB |
No variants for Q754U8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q754U8 | |||||
No associated diseases with Q754U8
5 regional properties for Q754U8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | ATP-dependent RNA helicase DEAD-box, conserved site | 433 - 441 | IPR000629 |
| domain | Helicase, C-terminal | 498 - 668 | IPR001650 |
| domain | DEAD/DEAH box helicase domain | 300 - 474 | IPR011545 |
| domain | Helicase superfamily 1/2, ATP-binding domain | 295 - 502 | IPR014001 |
| domain | RNA helicase, DEAD-box type, Q motif | 275 - 304 | IPR014014 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.13 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| nucleic acid binding | Binding to a nucleic acid. |
| RNA helicase activity | Unwinding of an RNA helix, driven by ATP hydrolysis. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| mRNA branch site recognition | Recognition of the pre-mRNA branch site sequence by components of the assembling spliceosome. |
| mRNA splicing, via spliceosome | The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEPNTPAIDP | KKERLARWKQ | KKQQQDMLRQ | KSGASSKSSH | DQAEDGDAAR | STQPFEGLDK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| MAERRKRLEL | WKKKKKEQDE | QKWKGDDAGQ | ESATDIPVKG | KAAPAEDAKA | VPRGRKSRKG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ADPEKRQIWD | DSDDELEAPK | LKLFKPGSTI | QTETPPDEDP | EDTLDTYMNT | IQEKNEVQLL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| APREVFDQED | DETTAFDYNR | TDNGTGSEFM | RLAKLKAKKQ | LKPVIYSADE | LKPFIKNFYQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EPEEISKLSE | EEVADLRLSL | DNVQVRGRDC | PRPILKWSQL | GLNSGIMNLL | TRELEFTVPT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PIQAQAIPAI | MSGRDVIGIS | KTGSGKTVSF | ILPLLRQIKA | QRPLGGDETG | PLGLILSPTR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ELALQIHEEV | TKFTSGDPSI | RSLCCTGGSE | LKRQINDIKR | GVEIVIATPG | RFIDLLSLNS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GNLINPKRIV | FVVMDEADRL | FDLGFEPQVN | QIMKCIRPDK | QCVLFSATFP | NKLKSFASKI |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LHDPVYITVN | SKSLINENIE | QKVEIFSNEE | DKFKSLIHWL | ALTQQNLNDE | KTIVFVSSQQ |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ICDILYNRLE | ANGFTTFAIH | AGKIYTERAW | NLKCFKETAN | GILICTEVLS | RGLNVPEVSL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| VIIYNAAKTF | AQYVHTTGRT | ARGSNKGTAL | TLLMNTELAA | SYILMKSMRD | EELNKHHDAT |
| 670 | 680 | 690 | 700 | 710 | 720 |
| VSTLKQMSEK | FNKGLKTGEY | RLVKGFGGKG | LDHLGKVYEE | KHTEERNQLA | LEAGLAATEV |
| 730 | 740 | 750 | 760 | 770 | 780 |
| SVSAPDGGLG | DESTSVSIPK | LDYTVKKRSN | PDGTSTYFAH | VQVNDLPQIV | RWEATKYTTL |
| 790 | 800 | 810 | 820 | 830 | 840 |
| SSIKHETGCS | ITNKGRYYPS | GQGPQGPSDE | PRLYLLVESA | TDQDISLAID | LLESKVRDGV |
| 850 | |||||
| RKSNMQEIRS | NKYTI |