Q753X4

PR
Gene name
01-Oct (AFR198W)
Protein name
Mitochondrial intermediate peptidase
Names
MIP, Octapeptidyl aminopeptidase
Species
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
KEGG Pathway
ago:AGOS_AFR198W
EC number
3.4.24.59: Metalloendopeptidases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

15-115 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q753X4

Entry ID Method Resolution Chain Position Source
AF-Q753X4-F1 Predicted AlphaFoldDB

No variants for Q753X4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q753X4

No associated diseases with Q753X4

1 regional properties for Q753X4

Type Name Position InterPro Accession
domain Peptidase M3A/M3B catalytic domain 299 - 766 IPR001567

Functions

Description
EC Number 3.4.24.59 Metalloendopeptidases
Subcellular Localization
  • Mitochondrion matrix
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
mitochondrial matrix The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

2 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
metalloendopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.

5 GO annotations of biological process

Name Definition
cellular iron ion homeostasis Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.
peptide metabolic process The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another.
protein processing involved in protein targeting to mitochondrion The cleavage of peptide bonds in proteins, usually near the N terminus, contributing to the process of import into the mitochondrion. Several different peptidases mediate cleavage of proteins destined for different mitochondrial compartments.
protein stabilization Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MFVRFYKRLD RQYIQSQRRW ILSSNKCLLQ GNKNATISPL RRAFDDQDHW EESQAQNTSS
70 80 90 100 110 120
EQDNKGKNSS YFWSRSKATA PQVAHTGLFQ NPYLNSPEGL RKFANKSLTE ATALVRNLRE
130 140 150 160 170 180
DSSQEGLVRY IIRLDQLSDI LCRVIDLCEF LRAAHPDEQF VAAAQECHEQ MFEIMNILNT
190 200 210 220 230 240
DVVLCKRLKQ VLSDENISSK LSSEEIRVGH ILLEDFEKAG AYASPEVRKQ FIQLSQNISI
250 260 270 280 290 300
IGQDFINNTE SLSSSYIKIP CKDLESSGTS HLVLRQLTKD TMGNNYKIPT SGYAPYTLLN
310 320 330 340 350 360
ACPSEAIRRQ VWTAMFSCSE KQVKRLKSLL QLRRKLANIM GATDYVSYQL EGKMAKSPEN
370 380 390 400 410 420
VKNFLNTLVD HTKPLAAGEL EELAKLKRNV ENLSETNTLK LMRPWDRDYY SSLSPNFTRP
430 440 450 460 470 480
NHRVDGFTSI NTYFSLGVVM QGISDLFRDI YGISLKPVVA QAGETWAPDV RKLQVISETE
490 500 510 520 530 540
GIIGLIYCDL LERPGKTTSP SHFTVCCSRQ IYPEENDFST IQVGENPDGS RFQMPVISLI
550 560 570 580 590 600
CNFRATRHGK NKSLCLLELS DVETLFHEMG HALHSMLGRT QLQNLSGTRC VTDFVELPSI
610 620 630 640 650 660
LMEHFAKDRR VLLRISSNYA TGEPIPEELL SAFQEQNNFL KNTETFSQIK MSMLDQRLHS
670 680 690 700 710 720
ITDQDDIIAV YHGLEREMEV LVDDQTNWCG RFGHLFGYGA SYYSYLMDRA IAAKIWDHLF
730 740 750 760 770
KKDPFSRSSG EKFKEGVLKW GGSRDAWQCI ADALDEPRLV KGDDWAMRFI GEVEDM