Q753V5
Gene name |
RAD5 (AFR220W) |
Protein name |
DNA repair protein RAD5 |
Names |
|
Species |
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) |
KEGG Pathway |
ago:AGOS_AFR220W |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q753V5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q753V5-F1 | Predicted | AlphaFoldDB |
No variants for Q753V5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q753V5 | |||||
No associated diseases with Q753V5
6 regional properties for Q753V5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | SNF2, N-terminal | 368 - 769 | IPR000330 |
| domain | Helicase, C-terminal | 914 - 1072 | IPR001650 |
| domain | Zinc finger, RING-type | 831 - 880 | IPR001841 |
| domain | Helicase superfamily 1/2, ATP-binding domain | 361 - 660 | IPR014001 |
| domain | HIRAN domain | 148 - 256 | IPR014905 |
| conserved_site | Zinc finger, RING-type, conserved site | 851 - 860 | IPR017907 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP-dependent activity, acting on DNA | Catalytic activity that acts to modify DNA, driven by ATP hydrolysis. |
| ATP-dependent chromatin remodeler activity | An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling. |
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| helicase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix. |
| hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. |
| zinc ion binding | Binding to a zinc ion (Zn). |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MQRTGDGERP | RFFQQDLDVI | PDDKGSDLFI | QTAEGPDGHV | DDEVIEDKTR | FITNLKEVLG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ALPDDILEGY | WNSYGASKDG | LSKAIQQHFE | GKETKGCSDA | HDDLNTETQN | SQNTIVNGHV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SNQIKRASEG | GLPILKRKKQ | LCCWRRFLGS | TQVNAMATRP | TAQPLKYGSE | LLIRRTSGQP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NNSGLRSRKK | PGFSQYVRFC | DATSSRELGR | LPEDISEILH | TLLQTPGVEF | KATMIFCNSK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RLSVGDLFVV | RLDCFVTSLL | FDPALPGKAE | DEQFQQRNRA | LMLLFKNLNM | TPLAEGADLV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PEKPEFYDLE | EDESITDATV | NSPTASDDYM | DLNQLRNFYR | STQESASIFK | LRETTPPVDK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FQLELRRYQK | QGLTWMLLRE | REHAILEPGS | QDALADGPMD | PMWRMFKWPR | DTSWDVSRGT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TYVSLEADIP | DKFYANLHTG | EFSLVKPISK | SILKGGILAD | EMGLGKTISI | LALITMVPSD |
| 490 | 500 | 510 | 520 | 530 | 540 |
| TKHLLTTAQE | KPPVGHLSLE | LGISTVKPYT | ASTTLIVVPM | SLLPQWRNEF | VRVNDGNGLY |
| 550 | 560 | 570 | 580 | 590 | 600 |
| CEVYYAGNVS | NLRTLLVKQK | SPPSVVLTTY | GVVQTEWSKL | QQFDYEASNE | GLFSVEFFRI |
| 610 | 620 | 630 | 640 | 650 | 660 |
| ILDEGHNIRN | RTTKTSKAVM | ALTSRRKWVL | TGTPIMNRLD | DLFSLIKFMN | FEPWCKIDYW |
| 670 | 680 | 690 | 700 | 710 | 720 |
| RQFVSDPFEK | KDYSSALEVI | QAVMGPILLR | RTKNMKDEDG | NPLVQLPPKE | VVIEMIRFSD |
| 730 | 740 | 750 | 760 | 770 | 780 |
| TEAGLYKYFL | SKAEHSVKES | LARGDLLKKY | STILLHILRL | RQVCCHFKLL | GSQDENDEDL |
| 790 | 800 | 810 | 820 | 830 | 840 |
| KNMKLINDIP | DISTLLGEDS | QSPGSSSEGM | PDFIEDFKTK | YPNSDALKDL | ECSICTCEAI |
| 850 | 860 | 870 | 880 | 890 | 900 |
| SPLTSVVFTR | CGHPFCESCL | LEYIQFQNKK | GSETICPNCR | AAVESRYLLK | LEDINGKLEP |
| 910 | 920 | 930 | 940 | 950 | 960 |
| VPYSNTKKSS | KIVALIRHLK | HLQDTSANEQ | VVVFSQFSSY | LDILENELRQ | SFASDICEIY |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| KFDGRLDLKE | RSNVLAKFTE | KSLVKMKVLL | LSLKAGGVGL | NLTCASHAFI | MDPWWSPGME |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| DQAMDRIHRI | GQSNTVKIYR | FIVENSIEEK | MLRIQEKKRS | LGEFVDADEE | ERRRSRIEEI |
| KMLFA |