Q750S2

PR
Gene name
SCC2 (AGL133W)
Protein name
Sister chromatid cohesion protein 2
Names
Species
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
KEGG Pathway
ago:AGOS_AGL133W
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-191 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for Q750S2

Entry ID Method Resolution Chain Position Source
5C6G X-ray 260 A B/D 1-218 PDB
5ME3 X-ray 285 A A/B 378-1479 PDB
AF-Q750S2-F1 Predicted AlphaFoldDB

No variants for Q750S2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q750S2

No associated diseases with Q750S2

2 regional properties for Q750S2

Type Name Position InterPro Accession
domain Sister chromatid cohesion C-terminal domain 1190 - 1366 IPR024986
repeat HEAT repeat associated with sister chromatid cohesion protein 707 - 748 IPR026003

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
2-micrometer circle DNA A plasmid commonly found in Saccharomyces, inherited in a non-Mendelian manner and often present in 100-400 copies.
chromatin The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
Scc2-Scc4 cohesin loading complex A eukaryotically conserved heterodimeric protein complex (comprising adherin and the chromatid cohesion factor MAU2/Scc4/Ssl3) required for the loading of a cohesin, complex onto DNA.

3 GO annotations of molecular function

Name Definition
chromatin binding Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
kinetochore binding Binding to a kinetochore, a proteinaceous structure on a condensed chromosome, beside the centromere, to which the spindle fibers are attached.
sequence-specific DNA binding Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.

10 GO annotations of biological process

Name Definition
establishment of mitotic sister chromatid cohesion The process in which the sister chromatids of a replicated chromosome become joined along the entire length of the chromosome during S phase during a mitotic cell cycle.
establishment of protein localization to chromatin The directed movement of a protein to a part of a chromosome that is organized into chromatin.
mitotic chromosome condensation The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells.
mitotic cohesin loading The protein localization to chromatin by which a cohesin ring complex is topologically linked to DNA as part of the mitotic cell cycle.
positive regulation of cohesin loading Any process that activates or increases the frequency, rate or extent of cohesin loading.
rDNA chromatin condensation The process in which the chromatin structure of the rDNA repeats is compacted. In S. cerevisiae, condensation and resolution of the rDNA occurs during anaphase.
regulation of gene expression Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
replication-born double-strand break repair via sister chromatid exchange The repair of a replication-born double-strand DNA break in which the DNA molecule is repaired using the homologous sequence of the sister chromatid which serves as a template to repair the breaks.
transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery The chromosome organization process in which the DNA sequence containing a gene transcribed by RNA polymerase II is maintained in a specific location at the nuclear periphery. In S. cerevisiae, this process involves cis-acting DNA sequences such as the TATA box and upstream activating sequence (UAS) elements, trans-acting transcriptional activators, and also the 3'-UTR of the transcript.
tRNA gene clustering The process in which tRNA genes, which are not linearly connected on the chromosome, are transported in three dimensions to, and maintained together in, the nucleolus. This clustered positioning leads to transcriptional silencing of nearby RNA polymerase II promoters (termed tRNA gene mediated (tgm) silencing) in S. cerevisiae.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSTFPGEDTR IPKRISEALS HQPLNHLVPK RELSRLLSKP VQISVQLESE DAFEEVPEEL
70 80 90 100 110 120
WQYPHPIDLD PLRLEESQPL RFRRPRGARL DYREDSSEIA DLPGMGQLAR ACLSGTQLVD
130 140 150 160 170 180
SAAIVESIES NAKKRKQTLA IGDVEMVSPD KKTKVMASVS PVSLNRVALG SQHLKTLERL
190 200 210 220 230 240
MQYIGADESS AEFGDFEYWI TLEDRATHIL SEQCIDKLHI VFRNILSIPA VWTELDVSLL
250 260 270 280 290 300
QRIMDVCVST ITICLEKIEL KEYSHDYTLI AFGSSMVVFF IFLLDQNDRR LQLEQYMMVP
310 320 330 340 350 360
LQFLTFTADN LEEEFDRGGN GVERSLAMLH STLDVFYMYI SNKPKLDDGL VVKLVYMFTE
370 380 390 400 410 420
LIMSTWSHNV SSVSLQNHIG NVKTIGMKSI EVLFEKLPEQ RLFIIDELLS HLDNLPNTRS
430 440 450 460 470 480
QKRMKNIGKN LHITHFSYIM LSILQVWNNY DYCSNLVSPD TEQLHDLIAH HAATQSDLEF
490 500 510 520 530 540
AADHIIDTIL KKCFSNISKY RFVFDQFVTD MTTVVTLPDW PVSDLILARL LKKLLSIFNP
550 560 570 580 590 600
QSQKHINIES VALQGIGLIG STILDIRLSS NSNPTANLIH LFNYPEDIDG LFKAYRTCLA
610 620 630 640 650 660
YCTNSVQHHT PYKFLWCKQL DVLTKLKEMD KESQGWGSKL QQKFLSLIES IHLPLEQAAN
670 680 690 700 710 720
LGAVEILPTY CSTLLTSELI NMYEPYLKLV LSLLERHKVK LRSGAIRCLA LLISKDKNML
730 740 750 760 770 780
YTPIVKETIE NRLTDSSPLV KDAILELIEL GSSYIDFYQH ININYNDDSM LVRKHVLRMN
790 800 810 820 830 840
QIIYDDTEDI IIKAYVASRI LRRIEDEEDV IIETARSELL KRWILSIQCP NAKPELQIKN
850 860 870 880 890 900
CRVSIRVIAQ LLVGGDKICD LFEHFLIFYV LNKNAHTEDQ NKLISSSLCL LTDQVIEMVI
910 920 930 940 950 960
ENEAADVDNQ REEEGRNIMK FLSVLSSCQD SFITKDHITA LYPYLHSDTK SDFQLHILKV
970 980 990 1000 1010 1020
YRNTFEQLSH FKPKFLYDLE TTILSRLPRM NVRELDEAIP LSWSLSRHRK DDTRICKACA
1030 1040 1050 1060 1070 1080
SCLGQLSPYI ANATTDPSAV RPDGKLQRLL YLATGFARFC SFENTEGKFP NLKTRENIFE
1090 1100 1110 1120 1130 1140
YVTKCLLMFT KENIHHVIRR IATKNLVKIA SRYPKLFNSR HVLTVLDTQF EKGILDIQLV
1150 1160 1170 1180 1190 1200
VLESLYDFFL AEERRSLIQV GVDGTISSNN ELRKVVANHT KSDSINDGIC SALVSRYLDK
1210 1220 1230 1240 1250 1260
ILKICLIADL NNAMVAIRFL KQILTYGYTN PSLCVPTVIA LTASPNSYMR DLSSEMFSEL
1270 1280 1290 1300 1310 1320
LQGYESMAFN CLNQGIRLGT EYAVKIRPKQ FHEDSMFLRR LQQLMSTNKR NRSKFLKVVK
1330 1340 1350 1360 1370 1380
KTVFSNYLST SVNYEESCYH IIYLLHNLSK ISYDNMLELY EMLRSVISVS EYFSDRISER
1390 1400 1410 1420 1430 1440
LDGFQSNQNT AAEVSAIIVT RLSIEEFKRF MFEQHHLSEA KLTLLDATDD ENLRNKSVAA
1450 1460 1470
LDDQVGSLHM ENIFLGYENP INNKDYCWKY ISTLHRDEI