Q750A9

PR
Gene name
HOG1 (AGR048C)
Protein name
Mitogen-activated protein kinase HOG1
Names
MAP kinase HOG1
Species
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
KEGG Pathway
ago:AGOS_AGR048C
EC number
2.7.11.24: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

327-411 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

161-181 (Activation loop from InterPro)

Target domain

23-302 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q750A9

Entry ID Method Resolution Chain Position Source
AF-Q750A9-F1 Predicted AlphaFoldDB

No variants for Q750A9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q750A9

No associated diseases with Q750A9

4 regional properties for Q750A9

Type Name Position InterPro Accession
domain Protein kinase domain 23 - 302 IPR000719
conserved_site Mitogen-activated protein (MAP) kinase, conserved site 58 - 156 IPR003527
active_site Serine/threonine-protein kinase, active site 140 - 152 IPR008271
binding_site Protein kinase, ATP binding site 29 - 53 IPR017441

Functions

Description
EC Number 2.7.11.24 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
MAP kinase activity Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

5 GO annotations of biological process

Name Definition
cellular response to oxidative stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
osmosensory signaling pathway The series of molecular signals initiated in response to osmotic change.
protein phosphorylation The process of introducing a phosphate group on to a protein.
stress-activated MAPK cascade The series of molecular signals in which a stress-activated MAP kinase cascade relays a signal; MAP kinase cascades involve at least three protein kinase activities and culminate in the phosphorylation and activation of a MAP kinase.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MASQEEFYRT QIFGTVFEIT NRYADLNPVG MGAFGLVCSA VDTYTQQPVA IKKIMKPFST
70 80 90 100 110 120
AVLAKRTYRE LKLLKHLRHE NLICLEDIFL SPLEDIYFVT ELQGTDLHRL LQTRPLEKQF
130 140 150 160 170 180
LQYFLYQILR GLKYVHSAGV IHRDLKPSNI LINENCDLKI CDFGLARIQD PQMTGYVSTR
190 200 210 220 230 240
YYRAPEIMLT WQKYNVEVDI WSAGCIFAEM IEGKPLFPGK DHVHQFSIIT DLLGSPPKDV
250 260 270 280 290 300
IDTICSENTL KFVTSLPHRD PVPFTERFKN LKPDAVDLLE KMLVFDPKKR ITAGDALTHP
310 320 330 340 350 360
YLAPYHDPTD EPVADAKFDW NFNDADLPVD TWRVMMYSEI LDFHQVPDSQ INPNDTFDDQ
370 380 390 400 410 420
VAAATAAAEA ARQQQQQKQQ QQKQQQQRHQ GVEHGAQHVQ LQHGAKQLSA DPLVGDSNGG
430 440
IPLNVSAANE TLNNFANQAA QYATDFE