Q74ND5

PR
Gene name
proS
Protein name
Proline--tRNA ligase
Names
Prolyl-tRNA synthetase, ProRS
Species
Nanoarchaeum equitans (strain Kin4-M)
KEGG Pathway
neq:NEQ210
EC number
6.1.1.15: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

411-493 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q74ND5

Entry ID Method Resolution Chain Position Source
AF-Q74ND5-F1 Predicted AlphaFoldDB

No variants for Q74ND5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q74ND5

No associated diseases with Q74ND5

4 regional properties for Q74ND5

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 95 - 243 IPR002314
domain Anticodon-binding 351 - 440 IPR004154
domain Aminoacyl-tRNA synthetase, class II 34 - 344 IPR006195
domain Proline-tRNA ligase, class II, C-terminal 470 - 537 IPR016061

Functions

Description
EC Number 6.1.1.15 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
proline-tRNA ligase activity Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).

1 GO annotations of biological process

Name Definition
prolyl-tRNA aminoacylation The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. The prolyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a methionine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MVKKSENPKE WYNEIVRKAN IIDDAYPVKG MPVYKPYGYK AFKFLMSLLE NKLESIGAEP
70 80 90 100 110 120
AWFPIVIPYS IFKKESEHIK GFEEEVFWIE RAGNDKLEDP LILRPTSETE MYYMFAKWIE
130 140 150 160 170 180
SYRDLPLIIY MTNTVYRYET KSTKALIRGR EVLWNETHSV HRSEEDAREH MAKAKEVYDY
190 200 210 220 230 240
IFWDVLYLPY IWVRRPEWDK FPGGEETYAA DAIMPDGRFL QVGTIHLLGQ KFAIPFEIKF
250 260 270 280 290 300
LDYHPFYKKY GDPNIYIKDK NGNEYKVHAP KEFWEELEKG KLTKTYTIKI GDKEYTISSI
310 320 330 340 350 360
EEINEKLKEY DFRKYVWQTS YGISMRAFGG ALYWLGDDLG LVMPYKIAPI QIVIIPILGK
370 380 390 400 410 420
DDTKVIEYSK KVYELIKDKY RVYLDSDDTK TPGYKYYYYD LIGVPLRIDI GLKEVENNSI
430 440 450 460 470 480
TIVRRDNKKK YTISLNELEK IDQIFKEMEE DLKQKAKSFV NDMVVRVKTF DELKEAIEQN
490 500 510 520 530
KIAKAPFCMR ESCANQIKEL LHAEVRGTDI NPENAEKERC VYCGEPAKYW VYIGKTY