Q74E25

PR
Gene name
tyrS
Protein name
Tyrosine--tRNA ligase
Names
Tyrosyl-tRNA synthetase, TyrRS
Species
Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
KEGG Pathway
gsu:GSU1139
EC number
6.1.1.1: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

284-399 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q74E25

Entry ID Method Resolution Chain Position Source
AF-Q74E25-F1 Predicted AlphaFoldDB

No variants for Q74E25

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q74E25

No associated diseases with Q74E25

4 regional properties for Q74E25

Type Name Position InterPro Accession
conserved_site Aldo/keto reductase, conserved site 39 - 56 IPR018170-1
conserved_site Aldo/keto reductase, conserved site 145 - 162 IPR018170-2
conserved_site Aldo/keto reductase, conserved site 261 - 276 IPR018170-3
domain NADP-dependent oxidoreductase domain 17 - 289 IPR023210

Functions

Description
EC Number 6.1.1.1 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
RNA binding Binding to an RNA molecule or a portion thereof.
tyrosine-tRNA ligase activity Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H(+).

2 GO annotations of biological process

Name Definition
tRNA aminoacylation The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules.
tyrosyl-tRNA aminoacylation The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. The tyrosyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tyrosine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSVADQMALI KRGAVEILVE KELEEKLEKS AKTGVPLKIK AGFDPTAPDL HLGHTVLLHK
70 80 90 100 110 120
MRQFQQLGHE VIFLIGDFTG MIGDPTGKSE TRKALSREDV LRNAETYKEQ VFKILDPEKT
130 140 150 160 170 180
RVAFNSEWLA KLDAGGMIGL AAKYTVARML ERDDFGKRFA NQLPISIHEF LYPLIQGYDS
190 200 210 220 230 240
VALQADVELG GTDQKFNLLV GRELQREWGQ TPQTVITMPL LEGLDGVNKM SKSLGNYIGI
250 260 270 280 290 300
NEPADEIFGK IMSISDELML RYYELLSDLS MAEIDGMRTG IRDGSVHPME AKKQLGREVV
310 320 330 340 350 360
ARYHGAAAAT DAEEHFVKRF RDNQTPDEMP ELTLAATDEK VALCRLLAEA GLVKSNSEGR
370 380 390 400
RAIQQGGVKV NGEKVSDESL ELAATGVYVI QFGKRRFARI TFA