Q74AZ0

PR
Gene name
leuS
Protein name
Leucine--tRNA ligase
Names
Leucyl-tRNA synthetase, LeuRS
Species
Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
KEGG Pathway
gsu:GSU2209
EC number
6.1.1.4: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

343-428 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q74AZ0

Entry ID Method Resolution Chain Position Source
AF-Q74AZ0-F1 Predicted AlphaFoldDB

No variants for Q74AZ0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q74AZ0

No associated diseases with Q74AZ0

5 regional properties for Q74AZ0

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 42 - 53 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 420 - 621 IPR002300
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 662 - 782 IPR013155
domain Methionyl/Leucyl tRNA synthetase 41 - 182 IPR015413
domain Leucyl-tRNA synthetase, editing domain 221 - 407 IPR025709

Functions

Description
EC Number 6.1.1.4 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
leucine-tRNA ligase activity Catalysis of the reaction: L-leucine + ATP + tRNA(Leu) = AMP + diphosphate + 2 H(+) + Leu-tRNA(Leu).

1 GO annotations of biological process

Name Definition
leucyl-tRNA aminoacylation The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. The leucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a leucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQERYIPKNV EGKWQEIWEE NKTFTVTEDP SKPKYYLLEM FPYPSGRIHM GHVRNYSIGD
70 80 90 100 110 120
VVGRFKRMRG FNVLHPMGWD AFGMPAENAA IKHGSHPAKW TYENIDYMRS QLKKMGLSYD
130 140 150 160 170 180
WGRELATCDV DYYKWEQKMF LEMYEKGLVY KKSSFVNWCP ACETVLANEQ VEDGCCWRCD
190 200 210 220 230 240
SDVTQKELDQ WFFRITRYAE ELLEDTWNLP GWPERVLVMQ RNWIGKSFGC EIDFPVEGKV
250 260 270 280 290 300
EKVKVFTTRQ DTLYGATFMS LAPEHPQALE LTTPERRAEV EAFIDKVKKT DKIKRTAEDF
310 320 330 340 350 360
EKEGVFTGAY CINPVTNLRM PVYLANFVLL DYGTGAVMAV PTHDQRDFEF ARTYDLPLQV
370 380 390 400 410 420
VIQPEGETLD PAAMTAAYTE VGTMVNSGPF NGMKSDEAKE KIADYLEQEG VGTKTVNYRL
430 440 450 460 470 480
RDWGISRQRY WGNPIPVINC DICGVVPVPD KDLPVVLPMD AEFTGEGGNP LARVESFVNV
490 500 510 520 530 540
TCPQCGAEAR RETDTMDTFV QSSWYFLRYC CPDFACGPID RARAGYWMPV DQYIGGIEHA
550 560 570 580 590 600
VLHLLYSRFF TKALRDLGYV TVAEPFKNLL TQGMVIKDGA KMSKSKGNVV DPDALIERYG
610 620 630 640 650 660
ADTARLFTLF AAPPEKDLDW SDQGVEGSFR FLNRVWRLVF EVLPFIGSAG KPDPAALGDG
670 680 690 700 710 720
ARDLRRTVHK TIRKVTDDLD ERFHFNTAIS AVMELVNAIQ SFEPKNAPEN APVLREAVES
730 740 750 760 770 780
VVQLLAPFVP HVAEELWESL GHQGGVEASG WPSYDPEATV EEELLIVVQV NGKLRGKVTV
790 800 810 820
AVDAGEEQVK AAAFADDKVK PWLDGKQIRK AIYVPGKLLN IVVG