Q740U6

PR
Gene name
ileS
Protein name
Isoleucine--tRNA ligase
Names
Isoleucyl-tRNA synthetase, IleRS
Species
Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10) (Mycobacterium paratuberculosis)
KEGG Pathway
mpa:MAP_1246
EC number
6.1.1.5: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-57 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q740U6

Entry ID Method Resolution Chain Position Source
AF-Q740U6-F1 Predicted AlphaFoldDB

No variants for Q740U6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q740U6

No associated diseases with Q740U6

4 regional properties for Q740U6

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 69 - 80 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 39 - 665 IPR002300
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 713 - 850 IPR013155
domain Isoleucyl tRNA synthetase type 2, anticodon-binding domain 671 - 837 IPR033709

Functions

Description
EC Number 6.1.1.5 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

5 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
isoleucine-tRNA ligase activity Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H(+).
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
isoleucyl-tRNA aminoacylation The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. The isoleucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a isoleucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTDNLGFQAD REAQPADSVQ TYPKPAGGAP DFPALELEVL DYWARDDTFR ASIARRDGAE
70 80 90 100 110 120
EYVFYDGPPF ANGLPHYGHL LTGYVKDIVP RYRTMRGNKV ERRFGWDTHG LPAELEVERQ
130 140 150 160 170 180
LGITDKSQID DMGIAAFNDA CRESVLRYTD EWRAYVTRQA RWVDFDHDYK TLDLPYMESV
190 200 210 220 230 240
IWAFKQLWDK GLAYEGYRVL PYCWRDETPL SNHELRMDDD VYPSRQDPAL TVGFKVVGGE
250 260 270 280 290 300
LDGAHLLIWT TTPWTLPSNL AVAVHPEVTY VQVRSGDRRF VLAQPRLAAY ARELGPEPEI
310 320 330 340 350 360
LGSYRGAELL GTRYLPPFPY FMDNPNAFRV LAGEFVTTED GTGIVHLAPA YGEDDMAVAD
370 380 390 400 410 420
AAGIAPVTPV DSNGRFDAAV PDYQGLNVFD ANPQIIWDLK NGSGAAAANA PVLLRHETYE
430 440 450 460 470 480
HPYPHCWRCR NPLIYRAVSS WFVAVTRFRD RMVELNQQIT WYPEHVKDGQ FGKWLAGARD
490 500 510 520 530 540
WSISRNRYWG TPIPVWKSDD PAYPRIDVYG SLDELERDFG VRPDNLHRPY IDELTRPNPD
550 560 570 580 590 600
DPSGRSTMRR IPDVLDVWFD SGSMPYAQVH YPFENRDWFE THYPGDFIVE YIGQTRGWFY
610 620 630 640 650 660
TLHVLATALF DRPAFKTCVA HGIVLGSDGQ KMSKSLRNYP DVSEVFDRDG SDAMRWFLMA
670 680 690 700 710 720
SPILRGGNLI VTEQGIRDGV RQVLLPFWNA YSFLALYAPK IGTWRTDSPQ VLDRYILAKL
730 740 750 760 770 780
AELRDDLTRE MDACDISRAC EQLRQFTEAL TNWYVRRSRS RFWSEDADAI DTLHTVLEVT
790 800 810 820 830 840
ARLAAPLLPS VTELVWRGLT GGRSVHLTDW PRSGELPADP GLVAAMDQVR EVCSAASSLR
850 860 870 880 890 900
KAKKLRVRLP LPKLTVAVEN PQHLAPFVDL IADELNVKSV ELTDAIDTYG TFELTVNARV
910 920 930 940 950 960
AGPRLGKDVQ AAIKAVKAGE GVVNADGTLT AGPAVLRPEE YSSRLVAADP EFTAALPNGA
970 980 990 1000 1010 1020
GLVVLDGTVT PELEAEGWAK DRIRELQELR KSTGLDVSDR ISVVMSVPAG RAEWARTHRD
1030 1040 1050
LIAGEILATR FEFGEPADPV AIGDGVRVSI SKV