Q73QY2
Gene name |
thyX |
Protein name |
Flavin-dependent thymidylate synthase |
Names |
FDTS, FAD-dependent thymidylate synthase, Thymidylate synthase ThyX, TS, TSase |
Species |
Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104) |
KEGG Pathway |
tde:TDE_0311 |
EC number |
2.1.1.148: Methyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q73QY2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q73QY2-F1 | Predicted | AlphaFoldDB |
No variants for Q73QY2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q73QY2 | |||||
No associated diseases with Q73QY2
No regional properties for Q73QY2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q73QY2 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 2.1.1.148 | Methyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| flavin adenine dinucleotide binding | Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. |
| thymidylate synthase (FAD) activity | Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP + NADPH + H+ = dTMP + tetrahydrofolate + NADP+. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| dTMP biosynthetic process | The chemical reactions and pathways resulting in the formation of dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate). |
| dTTP biosynthetic process | The chemical reactions and pathways resulting in the formation of dTTP, deoxyribosylthymine triphosphate. |
| methylation | The process in which a methyl group is covalently attached to a molecule. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDKEFKVLDK | GFIRLVDYMG | TDARIVQSAR | VSYGEGTKTV | REDAALIDYL | LRNKHTSPFE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QVVFTFHVKL | PIFVARQWIR | HRTARLNEIS | GRYSILKAEF | YVPAGKDIAL | QSSDNKQGRM |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NEAVPQDLQN | EVITSLQKQQ | EEIYAGYSKL | LDKNIARELA | RINLPLSTYT | EWYWQIDLHN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LFHFLRLRMD | AHAQKEIRDY | AEVMFEICKT | VTPLACASFE | RHEKNGVNFS | AEELEAIRNL |
| 250 | 260 | ||||
| IAGKDSGLKG | KELERFNEKL | KSGRQV |