Q73MZ2

PR
Gene name
valS
Protein name
Valine--tRNA ligase
Names
Valyl-tRNA synthetase, ValRS
Species
Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)
KEGG Pathway
tde:TDE_1364
EC number
6.1.1.9: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-43 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q73MZ2

Entry ID Method Resolution Chain Position Source
AF-Q73MZ2-F1 Predicted AlphaFoldDB

No variants for Q73MZ2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q73MZ2

No associated diseases with Q73MZ2

5 regional properties for Q73MZ2

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 52 - 63 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 23 - 570 IPR002300
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 629 - 783 IPR013155
domain Valyl-tRNA synthetase, tRNA-binding arm 844 - 908 IPR019499
domain Valyl tRNA synthetase, anticodon-binding domain 582 - 720 IPR033705

Functions

Description
EC Number 6.1.1.9 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
valine-tRNA ligase activity Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H(+).

1 GO annotations of biological process

Name Definition
valyl-tRNA aminoacylation The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. The valyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a valine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSEKLQAIEL EKSYNPKEFE ERIYSFWEAN KCFSPIKKKN TKNTFTVVIP PPNVTGVLHV
70 80 90 100 110 120
GHALDETLQD VIVRYHRMKG DETLWIPGTD HAGIATQSVV EKKLKAEGKN RRDLGREAFI
130 140 150 160 170 180
EKVWEVKNEH HSIITKQLRK MGVSVDWDRE RFTLDEGLSQ AVREVFVSLY EQGLIYQGNY
190 200 210 220 230 240
LVNWCPSCGT AISDDEVEHE DRKGGMYHIY YKLADGAVLQ NEAGEKIQEI EIATTRPETL
250 260 270 280 290 300
LGDTAIAVHP EDPRYASIIG KEVILPLANR KIPVIADSYV DKEFGTGVVK ITPAHDPNDW
310 320 330 340 350 360
EVGKRHNLPV LNILNPDGTL NDAVPEKYRG LSTEKARKAV IEDLEELGLF KNEEKIKHAV
370 380 390 400 410 420
GCCYRCHTSI EPYVSKQWFV KMQPLAQKAL DAWKKGDVVF YPQKWENTYA HWMNNIRDWC
430 440 450 460 470 480
ISRQLWWGHR IPVWYCADCG KTIVSRTDIT ECPHCKSKNI KQDEDVLDTW FSSWLWPFST
490 500 510 520 530 540
LGWPEKTEDL ARFFPTSALV TGHDIIFFWV ARMIMASLQF TGKAPFKDIF IHGLVRDKQG
550 560 570 580 590 600
RKMSKSLGNG IDPLVAIEEF GADAMKFTLT FMCGSQSQDF LIDMESFKLG SKFANKVWNA
610 620 630 640 650 660
SRYILGNLAG RTIVPVGRDG SLNSLKELDR WIYHELNEAA QTVRSSLDSY RYNEAAQKVY
670 680 690 700 710 720
EFFWNNFCDW YVEGTKLSFK YGDEKEKDRA ASVLLAVLEE SLRLLHPFLA FVTEEIYSKL
730 740 750 760 770 780
PGNCAEGALP RAKILMTSDY PEEKKERIDE AASIRFRTLQ EIVRNIRALR AECGIDPQLK
790 800 810 820 830 840
LKVSLYIEKN SPAEAARENS EIIEMLSGLS GLDFIDSLKE KPASSIGVVG AGFEAFLITG
850 860 870 880 890 900
DSIDIDQLKK RFEKELEKNE QNASKIDSKL KNENFVKNAP PEVIEGEKEK HAEFLRRIEK
LKGYLEGMR