Q73K81

PR
Gene name
leuS
Protein name
Leucine--tRNA ligase
Names
Leucyl-tRNA synthetase, LeuRS
Species
Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)
KEGG Pathway
tde:TDE_2339
EC number
6.1.1.4: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

578-660 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q73K81

Entry ID Method Resolution Chain Position Source
AF-Q73K81-F1 Predicted AlphaFoldDB

No variants for Q73K81

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q73K81

No associated diseases with Q73K81

5 regional properties for Q73K81

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 45 - 55 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 629 - 655 IPR002300
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 710 - 817 IPR013155
domain Methionyl/Leucyl tRNA synthetase 42 - 187 IPR015413
domain Leucyl-tRNA synthetase, editing domain 222 - 418 IPR025709

Functions

Description
EC Number 6.1.1.4 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
leucine-tRNA ligase activity Catalysis of the reaction: L-leucine + ATP + tRNA(Leu) = AMP + diphosphate + 2 H(+) + Leu-tRNA(Leu).

1 GO annotations of biological process

Name Definition
leucyl-tRNA aminoacylation The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. The leucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a leucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAYPFSTIEP KWQKYWEENK TFKTVEDKNY PKDKRLYILD MFPYPSGDGL HVGHPEGYTA
70 80 90 100 110 120
TDIYSRFLRM SGYNVLHPMG FDSFGLPAEN YAIKTGIHPL ITTRKNMETF RKQIKSIGLS
130 140 150 160 170 180
YDWDREISTS EESYYKWTQW IFLQLFKKGL AYEKEAPINW CPSCLTGLAN EEVKDGKCER
190 200 210 220 230 240
CGAQIQRKNL RQWILKITEY AERLLEDLDE LDWPESIKIM QKNWIGKSTG AEVDFALVDK
250 260 270 280 290 300
DGKETGQKIK VYTTRPDTIF GATYMVLAPE HELVKSITTS NQEKAVAAYI EEAAKKSDLE
310 320 330 340 350 360
RTDLAKNKTG VFTGAYAINP LTEQKIPVWI SDYILISYGT GAIMAVPAHD ERDFEFAAQF
370 380 390 400 410 420
NLPKIKVVAG AEEWESGKRD FSEEPKACTT EDGYSVNSKQ FDGLKTEEAK TKITEHLENL
430 440 450 460 470 480
GIAKRAVNYK LRDWIFSRQR YWGEPIPLVH CPSCGIVPLN EHDLPLTLPQ VESYAPTGTG
490 500 510 520 530 540
ESPLAAIDSW VNTKCPKCGK EAKRETNTMP QWAGSCWYYL RFIDPHNNEA FADKEKCDYW
550 560 570 580 590 600
MPVDLYVGGT EHAVLHLLYA RFWHKVLYDL GLVSTKEPFT RLINQGMITS FAYMRKNKSL
610 620 630 640 650 660
VPVDKVKKIS ETEFEDIETG EKLEQVIAKM SKSLKNVINP DDIIKEYGAD TLRLYEMFLG
670 680 690 700 710 720
PLEVSKPWNT SGIMGVFRFL EKIWNLSDRE IYKTPVNDTS TPETKTLTVL LNKTIKKVTE
730 740 750 760 770 780
DTASLNFNTA ISQMMIFINE VSKHKKIPHY VWYNFVKLLN PYAPHLAEEL WQKMGNDESI
790 800 810 820 830 840
AYSHWPMFVE KFCVDQTCTV VVQVNGKLRG KFEAEAGTSK EELERLALSN EGAIRNIEGK
850
EIKKIITVPD KLVNIVVQ