Q73JB2

PR
Gene name
ileS
Protein name
Isoleucine--tRNA ligase
Names
Isoleucyl-tRNA synthetase, IleRS
Species
Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)
KEGG Pathway
tde:TDE_2663
EC number
6.1.1.5: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

187-256 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q73JB2

Entry ID Method Resolution Chain Position Source
AF-Q73JB2-F1 Predicted AlphaFoldDB

No variants for Q73JB2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q73JB2

No associated diseases with Q73JB2

3 regional properties for Q73JB2

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class Ia 18 - 661 IPR002300
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 725 - 874 IPR013155
domain Isoleucyl tRNA synthetase type 2, anticodon-binding domain 666 - 857 IPR033709

Functions

Description
EC Number 6.1.1.5 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

5 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
isoleucine-tRNA ligase activity Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H(+).
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
isoleucyl-tRNA aminoacylation The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. The isoleucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a isoleucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MYKPVDPKVD FAKQEEDVLK FWEKNDVFKK SVSSRDGRDN YIFFDGPPFA TGLPHFGHFV
70 80 90 100 110 120
PGTIKDIIPR YKTMKGFRVE RRFGWDCHGL PVENLIEKEL GLNSKTDIEK YGIDKFNEAC
130 140 150 160 170 180
RASVLRYVKE WKQTITRLGR WVDFENDYKT MEPAFMESIW WVMKSLWEKG LLYEGYYILP
190 200 210 220 230 240
YCPRCSTVLS NHELNLGGYK DVHDPAITVR FKTLSPVKTS PAGKAFEGKN ALPSDTYLLA
250 260 270 280 290 300
WTTTPWTLPS NLGLAVGADI DYALIEYDGA HYIMAVPRLE AYFAKSGKEE AKEYKLIWTK
310 320 330 340 350 360
KGAELEGLRY EPLFPYFKNL AADENGKNAE AGQGAFRVLI GDFVTTEDGT GIVHTAPGFG
370 380 390 400 410 420
EDDNRIFKDT GVPTVCPVDA ECKFTHEVSD YQGLFVKDAD KQIMERLKTE GKLFKKAQIL
430 440 450 460 470 480
HSYPHCWRCS SPLIYRAVAS WFVSVTKIKD KLLNANSKIN WQPDHIKTGR FGKWLEGARD
490 500 510 520 530 540
WAISRNRYWG NPIPIWKCPD CGETICVGSR EELKELSGVF PEDMHKHFVD KISIPCKKCG
550 560 570 580 590 600
GTMKRVSEVL DCWFESGSMP YAQQHYPFEN KEHFEKNFPA DFISEGLDQT RGWFYTLTIL
610 620 630 640 650 660
AAALFDEPAF KNCIVNGLVL AEDGKKMSKS LRNYTDPNEV IKQFGADALR LFLMNSNVVK
670 680 690 700 710 720
ADDLKYSDEG VRDVLKGILI PFWNSYSFYI TYANIDGVKP PHNAKVDGKD EGVEEFLAKL
730 740 750 760 770 780
NNPLDLWILS VTEKLVADVT EALDKYDLSQ AIPPMVEYID LLNNWYIRRS RRRFWKSEND
790 800 810 820 830 840
GDKSQAYETL YRALKKFSLV AAPVVPFITE SIWQNLRTES DALSIHLADY PDYNEKIRNS
850 860 870 880 890 900
ELEFKMKTVQ KAVSMGRALR YQFNLKIRQP LKAVEIVTLN PEEKRVLLEM EESIIEELNV
910 920 930 940 950 960
KEVIFHEKED ELVEYSAKAN FKVLGKELGP LMKKAAAIIE QMNSSEIQNI MEGATLSIDI
970 980 990 1000 1010 1020
EGKSVEITAD KIVINRIEKA SLKIVNEGTL TVGLNTELTE ELLMEGYIRD LVRGIQTLRK
1030 1040 1050 1060 1070 1080
ECGLDVTDRI KLYLSASQKN ADNKELEKAF ELFKDYVCDE TLTVQSSWLK TGELTKLGSI
1090
KTSLVEAGDY EWEIGIEKNN