Q72SI0

PR
Gene name
feoB (LIC_11402)
Protein name
Fe(2+) transporter FeoB
Names
Ferrous iron transport protein B
Species
Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni (strain Fiocruz L1-130)
KEGG Pathway
lic:LIC_11402
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

156-225 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q72SI0

Entry ID Method Resolution Chain Position Source
AF-Q72SI0-F1 Predicted AlphaFoldDB

No variants for Q72SI0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q72SI0

No associated diseases with Q72SI0

7 regional properties for Q72SI0

Type Name Position InterPro Accession
domain GTP binding domain 12 - 32 IPR006073-1
domain GTP binding domain 33 - 51 IPR006073-2
domain GTP binding domain 60 - 75 IPR006073-3
domain Ferrous iron transport protein B, C-terminal 468 - 519 IPR011640
domain Nucleoside transporter/FeoB GTPase, Gate domain 356 - 450 IPR011642-1
domain Nucleoside transporter/FeoB GTPase, Gate domain 526 - 671 IPR011642-2
domain FeoB-type guanine nucleotide-binding (G) domain 9 - 172 IPR030389

Functions

Description
EC Number
Subcellular Localization
  • Cell inner membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
ferrous iron transmembrane transporter activity Enables the transfer of ferrous iron (Fe(II) or Fe2+) ions from one side of a membrane to the other.
GTP binding Binding to GTP, guanosine triphosphate.

1 GO annotations of biological process

Name Definition
iron ion homeostasis Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGHSDSSKTF RILMAGNPNC GKSTLFNQLT GLRQKTGNYH GVTVEKAEGI FHHLDHSVKI
70 80 90 100 110 120
LDLPGAFSLG GSSEDKQITS RVLIGHEAGD RILFVMDASL AERSLQFLLQ ILELNVPVLV
130 140 150 160 170 180
AVTMKDVLEK KRVQLRLDLL SNEFGILFQY VNPKNGEGIK ELKDRIVSPK AFCLPIRSFP
190 200 210 220 230 240
WDSERENFLN DLLNSLSTEH SNSLKFVLTN SLKELSGEIL QKGLPGLSLF SETPSKLIRE
250 260 270 280 290 300
KFERFGKRFT YLEELTQKSI YIKKILSTAI VGDPIPNERV LSKADKILLH PFWGLVSFLG
310 320 330 340 350 360
IMALVFQALF TWSEMPMDWI ESCVRNVGTF VGDFLEEGPL RSLIQEGIIG GVGAVLVFIP
370 380 390 400 410 420
QISLLFLFIG ILEETGYIAR ASFVMDRFMG KFGLSGKSFI PLLSSAACAV PAIMGTRTIE
430 440 450 460 470 480
NKSDRLTTIL VSPLITCSAR YPVYVLVIGA IFPSKNILGI FNVQALTMFG LFLLGMIASM
490 500 510 520 530 540
FAALVFKKTF FKSDSSYFLM ELPAYNTPSI KSLALTVFKK LKAFLSTAGQ IILFISILLW
550 560 570 580 590 600
FLANYPRIDS SLYPNLTDAE LKKIQIRESY AGHSGKFMEP VLKPIGFDWK MGIGIITSFA
610 620 630 640 650 660
AREIMVSTLS IIYGVGGEES TDDLKEALLK DTDENGKPVW GLSNSVSLLL FFAFACQCMS
670 680 690 700
TLAVVKKETN SIFWPLFLFT YMTILAYSTS FIVFQVWQLF S