Q72JB2

PR
Gene name
leuD
Protein name
3-isopropylmalate dehydratase small subunit
Names
Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase
Species
Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27)
KEGG Pathway
tth:TT_C0866
EC number
4.2.1.33: Hydro-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

21-183 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q72JB2

Entry ID Method Resolution Chain Position Source
AF-Q72JB2-F1 Predicted AlphaFoldDB

No variants for Q72JB2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q72JB2

No associated diseases with Q72JB2

2 regional properties for Q72JB2

Type Name Position InterPro Accession
domain Aconitase A/isopropylmalate dehydratase small subunit, swivel domain 3 - 117 IPR000573
domain 3-isopropylmalate dehydratase, swivel domain 15 - 145 IPR033940

Functions

Description
EC Number 4.2.1.33 Hydro-lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
3-isopropylmalate dehydratase complex A heterodimeric enzyme complex composed of subunits leuC and leuD. Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.

1 GO annotations of molecular function

Name Definition
3-isopropylmalate dehydratase activity Catalysis of the reaction: (2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate.

1 GO annotations of biological process

Name Definition
leucine biosynthetic process The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLEKFTVIRG KAVPLRGEDI DTDRILPARF MKVLTFEGLG QYLFYDERFD EKGNPKPHPL
70 80 90 100 110 120
NDPRYRGATI LLVESGFGSG SSREHAPQAI KRAGFKAIIG ESFAEIFFGN ATAIGLPCVS
130 140 150 160 170 180
LSPEDLGVLF RSVEENPELE VEIDLVNQEV RFGDRTAPLS IREEAREALV EGLWDPIGEL
190 200
LEAGELLDQF DQKLPYPRRT E