Q723E1

PR
Gene name
prs2
Protein name
Putative ribose-phosphate pyrophosphokinase 2
Names
RPPK 2, 5-phospho-D-ribosyl alpha-1-diphosphate 2, Phosphoribosyl diphosphate synthase 2, Phosphoribosyl pyrophosphate synthase 2, P-Rib-PP synthase 2, PRPP synthase 2, PRPPase 2
Species
Listeria monocytogenes serotype 4b (strain F2365)
KEGG Pathway
lmf:LMOf2365_0538
EC number
2.7.6.1: Diphosphotransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

237-308 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q723E1

Entry ID Method Resolution Chain Position Source
AF-Q723E1-F1 Predicted AlphaFoldDB

No variants for Q723E1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q723E1

No associated diseases with Q723E1

3 regional properties for Q723E1

Type Name Position InterPro Accession
domain Phosphoribosyltransferase domain 148 - 273 IPR000836
conserved_site Phosphoribosyl pyrophosphate synthetase, conserved site 129 - 144 IPR000842
domain Ribose-phosphate pyrophosphokinase, N-terminal domain 5 - 121 IPR029099

Functions

Description
EC Number 2.7.6.1 Diphosphotransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
kinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
magnesium ion binding Binding to a magnesium (Mg) ion.
ribose phosphate diphosphokinase activity Catalysis of the reaction: D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + 2 H(+).

4 GO annotations of biological process

Name Definition
5-phosphoribose 1-diphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of 5-phosphoribose 1-diphosphate, also known as 5-phosphoribosyl-1-pyrophosphate.
nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates).
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
ribonucleoside monophosphate biosynthetic process The chemical reactions and pathways resulting in the formation of a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAGKMKLFSV TSERPLATKI ADYLDIPLCE VELQKFSDGE VKINIEESIR GTNAYVVQSM
70 80 90 100 110 120
NSNVNERLME LLIMVDALKR ASVHSINIIM PYYGYARQDR KARSREPITA KLMANLIQRA
130 140 150 160 170 180
GADRLITVDL HAAQIQGFFN IPIDHLSAIP LIGDYLIENY GEKDVVVVAP DHSGVVRARR
190 200 210 220 230 240
IADRLNAPIA ILNRKPRPHE DEIMSVIGDV KGKVAIVVDD IIDTGVRATT SADILLEKGA
250 260 270 280 290 300
VEVIACATHS VMAGNATERL QNSNIKEVIT SDSIDLPEDK QFDKLTTISI GRILGRAIEG
310
VQENRSLHPL F