Q71ZA9

PR
Gene name
thrS
Protein name
Threonine--tRNA ligase
Names
Threonyl-tRNA synthetase, ThrRS
Species
Listeria monocytogenes serotype 4b (strain F2365)
KEGG Pathway
lmf:LMOf2365_1580
EC number
6.1.1.3: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-63 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q71ZA9

Entry ID Method Resolution Chain Position Source
AF-Q71ZA9-F1 Predicted AlphaFoldDB

No variants for Q71ZA9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q71ZA9

No associated diseases with Q71ZA9

7 regional properties for Q71ZA9

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 321 - 533 IPR002314
domain TGS 1 - 60 IPR004095
domain Anticodon-binding 548 - 634 IPR004154
domain Aminoacyl-tRNA synthetase, class II 241 - 538 IPR006195
domain Threonyl/alanyl tRNA synthetase, SAD 168 - 217 IPR012947
domain Threonine-tRNA ligase catalytic core domain 241 - 543 IPR033728
domain Threonine-tRNA ligase, class IIa, anticodon-binding domain 543 - 634 IPR047246

Functions

Description
EC Number 6.1.1.3 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
threonine-tRNA ligase activity Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
threonyl-tRNA aminoacylation The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. The threonyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a threonine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKITFPDGAV KEFEPGVSTA DIAASISPGL KKKALAGKLN GELLDLVTPI HEDGAIEIVT
70 80 90 100 110 120
PDHEDALGIL RHSTAHLMAQ ALKRLYPDVK FGVGPAIESG FYYDIDTEAV ISDESLVEIE
130 140 150 160 170 180
KEMQKIVREN VPIEREVVSR EEAIKRFKAI GDQYKLELIE AIPEDETVTI YTQGEFFDLC
190 200 210 220 230 240
RGVHVPSTGK IQVFKLLSVA GAYWRGDSNN KMLQRIYGTA FFDKNGLKEF IQMQKEAKER
250 260 270 280 290 300
DHRKLGKELD LFANSIEVGQ GLPLWLPKGA TIRRVIERYI VDKEERLGYN HVYTPIMANV
310 320 330 340 350 360
ELYKTSGHWD HYHEDMFPTM KMDNEELVLR PMNCPHHMMI YKNDIHSYRE LPIRIAELGM
370 380 390 400 410 420
MHRYEMSGAL SGLQRVRGMT LNDAHVFVRP DQIKDEFKRV VELILEVYKD FDIKDYSFRL
430 440 450 460 470 480
SYRDPKNTEK YFDDDAMWEK AQAMLKSAMD EMEMDYFEAE GEAAFYGPKL DVQVKTAIGK
490 500 510 520 530 540
EETLSTVQLD FLLPERFDLT YIGEDGEKHR PVVIHRGVVS TMERFVAYLI EEYKGAFPTW
550 560 570 580 590 600
LAPVQMELIP VNADAHLDYA KGVQDKLQRA GLRAEVDDRN EKLGYKIREA QTKKIPYALV
610 620 630
LGDQEVEAGS VNVRRYGSKD SETMDLDAFI AQVVAEVSKY