Q70AM4

PR
Gene name
Kif13b (kif13B)
Protein name
Kinesin 13B
Names
Species
Equus caballus (Horse)
KEGG Pathway
rno:305967
EC number
5.6.1.6: Enzymes altering polypeptide conformation or assembly
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

390-432 (Coiled-coil 1) EV

Target domain

1-389 (Motor domain and neck coil)

Relief mechanism

Partner binding

Assay

Mutagenesis experiment, Structural analysis

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

0 structures for Q70AM4

Entry ID Method Resolution Chain Position Source

No variants for Q70AM4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q70AM4

No associated diseases with Q70AM4

12 regional properties for Q70AM4

Type Name Position InterPro Accession
repeat WD40 repeat 516 - 562 IPR001680-1
repeat WD40 repeat 565 - 610 IPR001680-2
repeat WD40 repeat 660 - 697 IPR001680-3
repeat WD40 repeat 703 - 742 IPR001680-4
repeat WD40 repeat 792 - 831 IPR001680-5
repeat WD40 repeat 832 - 869 IPR001680-6
repeat WD40 repeat 872 - 911 IPR001680-7
repeat WD40 repeat 918 - 956 IPR001680-8
repeat WD40 repeat 1032 - 1072 IPR001680-9
domain Doublecortin domain 166 - 253 IPR003533-1
domain Doublecortin domain 295 - 380 IPR003533-2
domain HELP 449 - 515 IPR005108

Functions

Description
EC Number 5.6.1.6 Enzymes altering polypeptide conformation or assembly
Subcellular Localization
  • Apical cell membrane ; Multi-pass membrane protein
  • Early endosome membrane ; Multi-pass membrane protein
  • Cell membrane ; Multi-pass membrane protein
  • Recycling endosome membrane ; Multi-pass membrane protein
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
  • Nucleus
  • The channel is internalized from the cell surface into an endosomal recycling compartment, from where it is recycled to the cell membrane
  • In the oviduct and bronchus, detected on the apical side of epithelial cells, but not associated with cilia
  • In Sertoli cells, a processed product is detected in the nucleus
  • ER stress induces GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
axon The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
kinesin complex Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work.
microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.

6 GO annotations of molecular function

Name Definition
14-3-3 protein binding Binding to a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction
microtubule binding Binding to a microtubule, a filament composed of tubulin monomers.
microtubule motor activity A motor activity that generates movement along a microtubule, driven by ATP hydrolysis.
protein kinase binding Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.

3 GO annotations of biological process

Name Definition
cytoskeleton-dependent intracellular transport The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell.
microtubule-based movement A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules.
regulation of axonogenesis Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9H1H9 KIF13A Kinesin-like protein KIF13A Homo sapiens (Human) SS
Q9NQT8 KIF13B Kinesin-like protein KIF13B Homo sapiens (Human) EV
Q9EQW7 Kif13a Kinesin-like protein KIF13A Mus musculus (Mouse) SS
10 20 30 40 50 60
MQRSPLEKAS VISKLFFSWT RPILRKGYRQ RLELSDIYQI PSADSADNLS EKLEREWDRE
70 80 90 100 110 120
LVSKKNPKLI NALRRCFFWR FMFYGIILYL GEVTKAVQPL LLGRIIASYD PDNEAERSIA
130 140 150 160 170 180
IYLGIGLCLL FIVRTLLLHP AIFGLHHIGM QMRIAMFSLI YKKTLKLSSR VLDKISIGQL
190 200 210 220 230 240
VSLLSNNLNK FDEGLALAHF VWIAPLQVTL LMGLLWDLLQ ASAFCGLAFL IVLALFQAGL
250 260 270 280 290 300
GRMMMKYRDQ RAGKINERLV ITSEMIENIQ SVKAYCWEEA MEKMIENLRQ TELKLTRKAA
310 320 330 340 350 360
YVRYFNSSAF FFSGFFVVFL SVLPYALIKG IVLRRIFTTI SFCIVLRMAV TRQFPWAVQT
370 380 390 400 410 420
WYDSLGAINK IQDFLQKQEY KTLEYNLTTT EVVMENVTAF WEEGFGELFE KAKQNNDRKI
430 440 450 460 470 480
SNGDNSLFFS NFSLLGTPVL KDISFKIERG QLLAVAGSTG AGKTSLLMMI MGELEPSEGK
490 500 510 520 530 540
IKHSGRISFC SQFSWIMPGT IKENIIFGVS YDEYRYRSVI KACQLEEDIS KFAEKDNIVL
550 560 570 580 590 600
GEGGIQLSGG QRARISLARA VYKDADLYLL DSPFGYLDVL TEKEIFESCV CKLMANKTRI
610 620 630 640 650 660
LVTSKMEHLK KADKILILHE GSSYFYGTFS ELQNLRPDFS SKLMGYDSFD QFSAERRNSI
670 680 690 700 710 720
LTETLRRFSL EGDATVSWNE TKKQSFKQTG EFGDKRKNSI LNPINSIRKF SIVQKTPLQM
730 740 750 760 770 780
NGIEEDSDEP LERRLSLVPD SEQGEAILPR SNVINTGPTF QRRRRQSVLN LMTRSSVNQG
790 800 810 820 830 840
QSIHRKTATS TRKMSLAPQA NLTEMDIYSR RLSQDSGLEI SEEINEDDLK ECFFDDVESI
850 860 870 880 890 900
PTVTTWNTYL RYITIHKSLI FVLIWCLVIF LAEVAASLVV LWLLKETPPQ DSGNSTKGAN
910 920 930 940 950 960
NSYAVIITST SSYYVFYIYV GVADTLLALG LFRGLPLVHT LITVSKILHH KMLHSVLQAP
970 980 990 1000 1010 1020
MSTLNTLKAG GILNRFSKDM AILDDLLPLT IFDFIQLLLI VIGAVAVVSV LQPYIFLATV
1030 1040 1050 1060 1070 1080
PVIAAFIILR AYFLHTSQQL KQLESEGRSP IFTHLVTSLK GLWTLRAFGR QPYFETLFHK
1090 1100 1110 1120 1130 1140
ALNLHTANWF LYLSTLRWFQ MRIEMIFVIF FIAVTFISIL TTGEGEGTVG IILTLAMNIM
1150 1160 1170 1180 1190 1200
STLQWAVNSS IDVDSLMRSV SRVFKFIDMP TEDSKPTKSV KPSKDGQLSK VMIIENQYVK
1210 1220 1230 1240 1250 1260
KDDIWPSGGQ MTVKDLTAKY TDGGNAILEN ISFSISPGQR VGLLGRTGSG KSTLLSAFLR
1270 1280 1290 1300 1310 1320
LLNTEGEIQI DGVSWDSITL QQWRKAFGVI PQKVFIFSGT FRKNLDPYGQ WNDQEIWKVA
1330 1340 1350 1360 1370 1380
DEVGLRSVIE QFPGKLDFVL VDGGNVLSHG HKQLICLARS VLSKAKILLL DEPSAHLDPI
1390 1400 1410 1420 1430 1440
TYQIIRRTLK QAFADCTVIL SEHRIEAMLE CQRFLVIEEN KVRQYDSIQK LLSEKSLFQQ
1450 1460 1470 1480
AISSSDPLKL FPHRNSSKHK SRSKIAALQE ETEEEVQETR L