AiPD: Autoinhibited Protein Database

Q6ZS10

Gene name	CLEC17A
Protein name	C-type lectin domain family 17, member A
Names	Prolectin
Species	Homo sapiens (Human)
KEGG Pathway	hsa:388512
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

15-88 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

15-88 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q6ZS10

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q6ZS10-F1	Predicted				AlphaFoldDB

286 variants for Q6ZS10

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA9255583 rs766081919	3	N>D		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	3	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA305701473 rs762497693	4	L>P		No	ClinGen TOPMed gnomAD
CA404444129 rs1337753453	6	S>Y		No	ClinGen gnomAD
rs1357938517 CA404444136	7	I>T		No	ClinGen TOPMed
rs1439831186 CA404444141	8	T>S		No	ClinGen gnomAD
CA9255584 rs753870592	9	G>R		No	ClinGen ExAC gnomAD
rs1323913230 CA404444157	10	Y>*		No	ClinGen TOPMed gnomAD
CA9255585 rs754849090	11	P>L		No	ClinGen ExAC TOPMed gnomAD
CA305701497 rs975391458 COSM3422467	12	D>N	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated Ensembl NCI-TCGA
rs748265594 CA404444171	13	P>A		No	ClinGen ExAC gnomAD
rs1463264110 CA404444173	13	P>L		No	ClinGen TOPMed
rs748265594 CA9255587	13	P>S		No	ClinGen ExAC gnomAD
rs540450558 CA9255588	14	P>L		No	ClinGen 1000Genomes ExAC gnomAD
CA404444175 rs1195864750	14	P>T		No	ClinGen gnomAD
CA9255618 rs770517338	15	G>E		No	ClinGen ExAC TOPMed gnomAD
CA404444205 rs1568442911	17	M>T		No	ClinGen Ensembl
CA9255619 rs776297892	17	M>V		No	ClinGen ExAC gnomAD
rs929782864 CA305701783	18	E>K		No	ClinGen TOPMed gnomAD
TCGA novel rs759261392 CA404444224	19	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA ClinGen ExAC TOPMed gnomAD
rs765055669 CA9255624	20	E>K		No	ClinGen ExAC gnomAD
rs1441236364 COSM991924 CA404444247	22	E>D	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
rs1446676949 CA404444255	23	D>E		No	ClinGen gnomAD
rs1351257388 CA404444279	26	Y>*		No	ClinGen TOPMed
CA9255627 rs762963063 COSM991925	27	E>D	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA305701800 rs1008366973	28	N>H		No	ClinGen TOPMed
CA9255628 rs764311250	28	N>S		No	ClinGen ExAC gnomAD
rs1290604234 CA404444301	30	T>A		No	ClinGen gnomAD
rs757315385 CA9255630	31	P>S		No	ClinGen ExAC TOPMed gnomAD
CA404444311 rs750595209	32	P>A		No	ClinGen ExAC gnomAD
rs750595209 CA9255632	32	P>S		No	ClinGen ExAC gnomAD
rs756540307 CA9255633	33	Y>*		No	ClinGen ExAC gnomAD
CA404444318 rs1160344271	33	Y>C		No	ClinGen TOPMed
CA404444319 rs1160344271	33	Y>F		No	ClinGen TOPMed
CA404444329 rs1432964303	34	K>N		No	ClinGen TOPMed
rs1599524169 CA404444334	35	D>G		No	ClinGen Ensembl
CA9255636 rs376824328	36	L>F		No	ClinGen ESP ExAC gnomAD
rs376824328 CA9255635	36	L>V		No	ClinGen ESP ExAC gnomAD
CA305701848 COSM3735542 rs200257988	37	P>S	Variant assessed as Somatic; impact. skin [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated Ensembl NCI-TCGA
CA404444349 rs1394605684	38	P>S		No	ClinGen TOPMed
rs1191326688 CA404444368	41	G>R		No	ClinGen TOPMed gnomAD
rs955417794 CA305704884	41	G>V		No	ClinGen TOPMed
rs1200125657 CA404444793	43	M>I		No	ClinGen gnomAD
rs367580965 CA9255657	43	M>T		No	ClinGen ESP TOPMed
CA9255659 rs552112270	44	E>K		No	ClinGen 1000Genomes ExAC gnomAD
rs1412313175 CA404444826	46	E>Q		No	ClinGen gnomAD
CA9255660 COSM1201340 rs780733761	48	E>D	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA404444883 rs1463228349	49	D>E		No	ClinGen TOPMed gnomAD
TCGA novel	55	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA404444971 rs1349072069	57	P>L		No	ClinGen gnomAD
CA9255661 rs745548943	57	P>S		No	ClinGen ExAC gnomAD
rs371803480 CA9255665	62	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA9255664 rs371803480	62	L>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs774223439 CA9255666	62	L>P		No	ClinGen ExAC gnomAD
CA9255667 rs761798951	63	P>L		No	ClinGen ExAC TOPMed gnomAD
CA9255668 rs767540826	64	P>S		No	ClinGen ExAC TOPMed gnomAD
CA404445028 rs1206920486	65	K>E		No	ClinGen gnomAD
rs1444264891 CA404445048	66	P>R		No	ClinGen TOPMed
rs1488731023 CA404445776	69	M>V		No	ClinGen gnomAD
CA9255689 rs760753767	70	E>K		No	ClinGen ExAC gnomAD
rs967125043 CA305707795	72	E>Q		No	ClinGen TOPMed gnomAD
rs567554376 CA9255692	74	E>D		No	ClinGen ExAC gnomAD
CA9255691 rs776904591	74	E>K		No	ClinGen ExAC TOPMed gnomAD
CA404445869 rs753137908 CA9255694	75	D>E		No	ClinGen ExAC TOPMed gnomAD
rs1354042720 CA404445865	75	D>G		No	ClinGen gnomAD
rs765562448 CA9255693	75	D>Y		No	ClinGen ExAC TOPMed gnomAD
rs764674868 CA9255697	77	D>E		No	ClinGen ExAC TOPMed gnomAD
rs763179467 CA9255695	77	D>H		No	ClinGen ExAC gnomAD
CA9255698 rs755756121	78	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA9255699 COSM228693 rs779700308	79	E>K	skin [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA404445958 rs1461340763	82	T>A		No	ClinGen gnomAD
CA9255701 rs754625408	83	P>L		No	ClinGen ExAC gnomAD
rs915727601 CA305707843	83	P>T		No	ClinGen TOPMed
CA404445980 rs1235356271	84	P>A		No	ClinGen TOPMed gnomAD
CA404445981 rs1235356271	84	P>S		No	ClinGen TOPMed gnomAD
rs1357649404 CA404445995	85	Y>C		No	ClinGen TOPMed
CA9255702 rs150637944	86	K>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1480982074 CA404446042	88	L>R		No	ClinGen TOPMed
rs771702851 CA9255704	89	P>L		No	ClinGen ExAC gnomAD
TCGA novel	93	G>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA404446552 rs1201595008	95	S>I		No	ClinGen gnomAD
CA404446563 rs1238584776	97	P>A		No	ClinGen TOPMed
rs1376019821 CA404446569	98	P>S		No	ClinGen gnomAD
rs1168756889 CA404446597	102	R>S		No	ClinGen gnomAD
rs777531272 CA9255723	104	A>T		No	ClinGen ExAC gnomAD
rs1599547115 CA404446629	106	E>K		No	ClinGen Ensembl
rs1356515128 CA404446639	107	T>S		No	ClinGen TOPMed
rs1162891939 CA404446663	110	P>L		No	ClinGen TOPMed
CA9255739 rs752452950	110	P>T		No	ClinGen ExAC gnomAD
rs757963370 CA9255740	111	P>L		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	111	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9255741 rs763915824	114	C>F		No	ClinGen ExAC TOPMed gnomAD
CA9255742 rs763915824	114	C>Y		No	ClinGen ExAC TOPMed gnomAD
CA404446690 rs1321976830	115	K>T		No	ClinGen TOPMed gnomAD
CA404446696 rs376222790	116	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs376222790 CA9255743	116	P>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs138054531 CA9255745	117	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9255744 rs369115211	117	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA404446711 rs1234286907	119	M>L		No	ClinGen TOPMed
CA9255746 rs756279350	119	M>T		No	ClinGen ExAC gnomAD
CA9255747 rs779979349	120	T>A		No	ClinGen ExAC gnomAD
TCGA novel	121	G>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1340191169 CA404446741	121	G>V		No	ClinGen gnomAD
CA9255763 rs78269670	122	L>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs375465288 CA9255764	123	D>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA9255767 rs755048797	125	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs367815850 CA9255769	126	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs772622288 CA9255770	127	V>F		No	ClinGen ExAC TOPMed gnomAD
CA404446769 rs772622288	127	V>I		No	ClinGen ExAC TOPMed gnomAD
CA404446778 rs1472777603	128	T>S		No	ClinGen gnomAD
CA9255772 rs747589482	129	C>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1267225767 CA404446794	131	P>A		No	ClinGen TOPMed
rs1176157078 CA404446801	132	P>R		No	ClinGen gnomAD
rs537474682 CA9255773	132	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs777139189 CA9255774	134	L>V		No	ClinGen ExAC gnomAD
CA404446863 rs1568453259	140	P>A		No	ClinGen Ensembl
CA305710743 rs368014882	140	P>L		No	ClinGen ESP TOPMed
rs1294599423 CA404446873	142	P>A	Variant assessed as Somatic; 4.641e-05 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1334702060 CA404446886	144	Q>*		No	ClinGen TOPMed
rs371871014 CA9255797	145	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA9255796 rs371871014	145	P>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1343142740 CA404446903	146	S>F		No	ClinGen gnomAD
CA305710787 rs1045706174	147	L>V		No	ClinGen TOPMed gnomAD
CA404446909 rs1272232438	148	A>P		No	ClinGen TOPMed gnomAD
CA404446908 rs1272232438	148	A>T		No	ClinGen TOPMed gnomAD
CA404447569 rs1449152790	149	A>E		No	ClinGen TOPMed gnomAD
rs368206109 CA9255800 COSM1480683	149	A>T	Variant assessed as Somatic; 9.282e-05 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs778589852 CA305712424	152	V>L		No	ClinGen Ensembl
CA404447609 rs1164780206	153	P>R		No	ClinGen gnomAD
rs747893944 CA305712437	155	L>F		No	ClinGen Ensembl
CA305712457 rs890108053 COSM3388646	156	N>S	pancreas [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA9255819 rs374642912	158	R>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs374642912 CA9255818	158	R>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs776533743 CA9255820	158	R>S		No	ClinGen ExAC gnomAD
CA9255821 rs759362478	161	G>S		No	ClinGen ExAC TOPMed gnomAD
CA9255822 rs201943272	162	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	163	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs775509873 CA9255823	164	C>Y		No	ClinGen ExAC gnomAD
TCGA novel	165	C>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9255824 rs763010053	166	Q>H		No	ClinGen ExAC gnomAD
rs764221793 CA9255825	168	R>M		No	ClinGen ExAC gnomAD
rs751779668 CA404447776	169	W>G		No	ClinGen ExAC gnomAD
rs751779668 CA9255826	169	W>R		No	ClinGen ExAC gnomAD
CA9255827 rs757472883	170	M>L		No	ClinGen ExAC TOPMed gnomAD
CA404447797 rs1599551464	171	V>G		No	ClinGen Ensembl
CA9255829 COSM1523794 rs750812921	172	Y>C	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs1300008457 CA404447808	173	L>P		No	ClinGen Ensembl
rs780540242 CA9255831	176	L>Q		No	ClinGen ExAC gnomAD
CA404447827 rs1171326452 CA404447829	177	V>L		No	ClinGen TOPMed
rs1599551532 CA404447837	178	V>G		No	ClinGen Ensembl
CA305712553 rs758358975	179	T>I		No	ClinGen Ensembl
rs749793508 CA9255832	179	T>S		No	ClinGen ExAC gnomAD
rs757901878 CA9255833	180	S>F		No	ClinGen ExAC gnomAD
CA9255834 rs777312777	181	L>P		No	ClinGen ExAC gnomAD
CA9255836 rs770646733	184	G>A		No	ClinGen ExAC gnomAD
rs770646733 CA404447869	184	G>V		No	ClinGen ExAC gnomAD
rs776374091 CA9255837	186	L>F		No	ClinGen ExAC TOPMed gnomAD
CA404447890 rs1357265241	188	L>F		No	ClinGen gnomAD
CA305712598 rs969992775	189	T>A		No	ClinGen Ensembl
rs745670773 CA9255838	193	I>N		No	ClinGen ExAC gnomAD
rs1599551658 CA404447931	195	Y>H		No	ClinGen Ensembl
rs1452323438 CA404447953	196	Q>*		No	ClinGen gnomAD
CA404447964 rs1201097378	197	E>V		No	ClinGen gnomAD
rs1169419690 CA404447982	199	M>I		No	ClinGen gnomAD
rs1192588879 CA404447978	199	M>T		No	ClinGen gnomAD
CA9255864 rs374356876	200	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA404447992 rs1427552541	201	E>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA9255866 rs140228268	204	M>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs866737571 CA305712751	208	Q>*		No	ClinGen Ensembl
rs1388391041 CA404448049	209	Q>*		No	ClinGen gnomAD
CA404448059 rs766766843	210	M>R		No	ClinGen ExAC TOPMed gnomAD
CA9255867 rs766766843	210	M>T		No	ClinGen ExAC TOPMed gnomAD
CA9255868 rs199539924	211	T>M		No	ClinGen ExAC TOPMed gnomAD
CA404448064 rs1599551974	211	T>P		No	ClinGen Ensembl
CA9255870 rs765787102	213	R>*		No	ClinGen ExAC TOPMed gnomAD
CA9255871 COSM991928 rs753078060	213	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA404448082 rs1225694558	214	T>A		No	ClinGen gnomAD
rs1352521000 CA404448084	214	T>K		No	ClinGen TOPMed
rs900874209 CA305714700	217	T>A		No	ClinGen TOPMed gnomAD
rs1452644078 COSM438733 CA404448454	218	G>S	breast [Cosmic]	No	ClinGen cosmic curated gnomAD
rs753431748 CA9255896	220	A>S		No	ClinGen ExAC gnomAD
TCGA novel	220	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs767654277 CA305714710	221	G>E		No	ClinGen TOPMed gnomAD
CA404448482 rs1311661328	222	L>R		No	ClinGen gnomAD
CA9255897 rs754856408	222	L>V		No	ClinGen ExAC gnomAD
TCGA novel	228	D>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs373607326 CA305714714	228	D>N		No	ClinGen Ensembl
rs778546672 CA9255898	229	I>T		No	ClinGen ExAC TOPMed gnomAD
CA9255899 rs200596379	230	A>D		No	ClinGen ExAC TOPMed gnomAD
CA404448532 rs200596379	230	A>G		No	ClinGen ExAC TOPMed gnomAD
CA404448533 rs200596379	230	A>V		No	ClinGen ExAC TOPMed gnomAD
rs375201326 CA9255900	231	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA9255901 rs777637590 COSM1600297	231	R>H	Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA404448553 rs770848670	234	A>D		No	ClinGen ExAC gnomAD
CA9255903 rs770848670	234	A>G		No	ClinGen ExAC gnomAD
CA9255902 rs747103231	234	A>T		No	ClinGen ExAC gnomAD
rs888597192 CA305714730	235	D>G		No	ClinGen TOPMed gnomAD
rs1240047942 CA404448567	236	T>S		No	ClinGen gnomAD
rs746055612 CA9255905 CA404448573	237	N>K		No	ClinGen ExAC TOPMed gnomAD
CA9255904 rs776977838	237	N>S		No	ClinGen ExAC gnomAD
rs1034573226 CA305714737	240	L>V		No	ClinGen Ensembl
rs763362627 CA9255908	243	L>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	244	W>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA404448621 rs774935127	245	G>C		No	ClinGen ExAC TOPMed gnomAD
CA9255910 rs774935127	245	G>S		No	ClinGen ExAC TOPMed gnomAD
CA9255912 rs760331798	246	L>F		No	ClinGen ExAC gnomAD
TCGA novel	248	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA404448660 rs1461871523	249	C>R		No	ClinGen gnomAD
CA9255931 rs762605332	250	R>C		No	ClinGen ExAC TOPMed gnomAD
CA9255932 rs776032874	250	R>H		No	ClinGen ExAC gnomAD
CA9255933 rs759035385	251	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs764808677 CA404448672	251	R>L		No	ClinGen ExAC TOPMed gnomAD
rs764808677 COSM1717320 CA9255934	251	R>Q	Variant assessed as Somatic; 0.0 impact. NS [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA404448675 rs1568457983	252	I>V		No	ClinGen Ensembl
CA404448682 rs1365730226	253	T>A		No	ClinGen gnomAD
rs752278108 CA9255935	253	T>I		No	ClinGen ExAC gnomAD
rs1262366644 CA404448694	255	P>S		No	ClinGen TOPMed
rs532904394 CA9255937	257	G>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9255936 rs532904394	257	G>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9255939 rs757174646	258	W>C		No	ClinGen ExAC gnomAD
CA9255938 rs751538925	258	W>S		No	ClinGen ExAC gnomAD
rs551331621 CA9255940	262	E>K		No	ClinGen 1000Genomes ExAC gnomAD
CA9255941 rs566111046	264	K>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA404448755 rs1568458033	264	K>N		No	ClinGen Ensembl
CA404448796 rs1450875157	270	P>S		No	ClinGen TOPMed gnomAD
CA404448795 rs1450875157	270	P>T		No	ClinGen TOPMed gnomAD
CA305714953 rs765087072	271	S>C		No	ClinGen Ensembl
rs1188676482 CA404448805	271	S>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1417754548 CA404448807	271	S>R		No	ClinGen gnomAD
CA9255943 rs780493792	275	W>*		No	ClinGen ExAC gnomAD
CA404448848 rs1356934064	277	E>G		No	ClinGen TOPMed gnomAD
CA9255945 rs769195760	279	R>Q		No	ClinGen ExAC gnomAD
rs527321709 CA9255944	279	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1459927765 CA404448868	280	M>I		No	ClinGen gnomAD
CA404448874 rs1568458106	281	F>S		No	ClinGen Ensembl
rs779385827 CA9255946	283	Q>*		No	ClinGen ExAC gnomAD
TCGA novel	284	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA404448925 rs1433082337	288	H>Y		No	ClinGen TOPMed gnomAD
CA9255948 rs772476572	290	V>I		No	ClinGen ExAC gnomAD
CA305715009 rs988095549	298	H>R		No	ClinGen TOPMed
rs1199358761 CA404447154	300	F>S		No	ClinGen TOPMed
rs913304283 CA305672492	305	H>D		No	ClinGen TOPMed gnomAD
CA404447249 rs1599577239	308	P>L		No	ClinGen Ensembl
rs1353497994 CA404447254	309	R>P		No	ClinGen TOPMed gnomAD
rs1353497994 CA404447255	309	R>Q		No	ClinGen TOPMed gnomAD
rs761612815 CA9255956	309	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1599577264 CA404447267	310	V>G		No	ClinGen Ensembl
rs1232554263 CA404447328	316	N>S		No	ClinGen TOPMed gnomAD
rs971986552 CA305672501	318	R>G		No	ClinGen TOPMed gnomAD
CA404447351 rs1221761185	318	R>K		No	ClinGen gnomAD
CA305672505 rs867937891	321	E>K		No	ClinGen gnomAD
rs767363026 CA9255957	323	D>G		No	ClinGen ExAC gnomAD
CA305672521 rs551939773	327	L>P		No	ClinGen 1000Genomes
CA305672530 rs981685777	329	G>R		No	ClinGen Ensembl
CA404447537 rs1222855703	334	L>F		No	ClinGen TOPMed
rs750373272 CA9255958	335	S>N		No	ClinGen ExAC TOPMed gnomAD
rs1346145627 CA404448116	336	F>S		No	ClinGen gnomAD
CA404448144 rs1375550336	339	P>R		No	ClinGen gnomAD
TCGA novel	343	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs762401802 CA9255970	345	I>T		No	ClinGen ExAC gnomAD
CA9255971 rs768312458	347	D>N		No	ClinGen ExAC TOPMed gnomAD
rs773989623 CA9255972	349	D>G		No	ClinGen ExAC gnomAD
CA9255973 rs372917327	350	C>R		No	ClinGen ESP ExAC gnomAD
rs767333885 CA9255974	350	C>Y		No	ClinGen ExAC gnomAD
rs750380113 CA9255975	351	A>T		No	ClinGen ExAC
rs935537288 CA305674117	351	A>V		No	ClinGen TOPMed
rs1433851272 CA404448237	352	T>A		No	ClinGen gnomAD
rs1287770447 CA404448239	352	T>I		No	ClinGen gnomAD
CA9255976 rs1345270005	354	N>H		No	ClinGen gnomAD
TCGA novel	354	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs760662849 CA9255978	355	K>E		No	ClinGen ExAC gnomAD
CA404448261 rs1398550789	355	K>R		No	ClinGen gnomAD
TCGA novel	359	W>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs766374913 CA9255979	363	S>F		No	ClinGen ExAC TOPMed
rs1408080301 CA404448331	365	Y>C		No	ClinGen gnomAD
rs546292965 CA9255980	367	T>I		No	ClinGen 1000Genomes ExAC gnomAD
CA9255981 rs369718540	368	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1331138643 CA404448350	368	T>P		No	ClinGen gnomAD
CA9255983 rs752957972	369	Y>N		No	ClinGen ExAC gnomAD
rs1234030363 CA404448366	370	W>*		No	ClinGen gnomAD
rs1171523317 CA404448370	371	I>V		No	ClinGen TOPMed
rs373656699 CA404448392	374	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs555278994 CA404448393	374	R>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9255986 rs555278994	374	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs373656699 CA9255985	374	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs896462597 CA305674144	378	C>Y		No	ClinGen TOPMed gnomAD

No associated diseases with Q6ZS10

1 regional properties for Q6ZS10

Type	Name	Position	InterPro Accession
domain	Thymidylate kinase-like domain	11 - 200	IPR039430

Functions

		Description
EC Number
Subcellular Localization	Membrane ; Single-pass type II membrane protein	In fibroblasts, expressed on the cell surface
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
cell surface	The external part of the cell wall and/or plasma membrane.
external side of plasma membrane	The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

5 GO annotations of molecular function

Name	Definition
carbohydrate binding	Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.
fucose binding	Binding to fucose, the pentose 6-deoxygalactose.
identical protein binding	Binding to an identical protein or proteins.
mannose binding	Binding to mannose, a monosaccharide hexose, stereoisomeric with glucose, that occurs naturally only in polymerized forms called mannans.
metal ion binding	Binding to a metal ion.

No GO annotations of biological process

Name	Definition
No GO annotations for biological process

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P25031	Reg3b	Regenerating islet-derived protein 3-beta	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MHNLYSITGY	PDPPGTMEEE	EEDDDYENST	PPYKDLPPKP	GTMEEEEEDD	DYENSTPPYK
70	80	90	100	110	120
DLPPKPGTME	EEEEDDDYEN	STPPYKDLPP	KPGSSAPPRP	PRAAKETEKP	PLPCKPRNMT
130	140	150	160	170	180
GLDLAAVTCP	PPQLAVNLEP	SPLQPSLAAT	PVPWLNQRSG	GPGCCQKRWM	VYLCLLVVTS
190	200	210	220	230	240
LFLGCLGLTV	TLIKYQELME	ELRMLSFQQM	TWRTNMTGMA	GLAGLKHDIA	RVRADTNQSL
250	260	270	280	290	300
VELWGLLDCR	RITCPEGWLP	FEGKCYYFSP	STKSWDEARM	FCQENYSHLV	IINSFAEHNF
310	320	330	340	350	360
VAKAHGSPRV	YWLGLNDRAQ	EGDWRWLDGS	PVTLSFWEPE	EPNNIHDEDC	ATMNKGGTWN
370
DLSCYKTTYW	ICERKCSC