Q6ZPR6

PR
Gene name
Ibtk (Kiaa1417)
Protein name
Inhibitor of Bruton tyrosine kinase
Names
IBtk
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:108837
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

961-1033 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6ZPR6

Entry ID Method Resolution Chain Position Source
AF-Q6ZPR6-F1 Predicted AlphaFoldDB

90 variants for Q6ZPR6

Variant ID(s) Position Change Description Diseaes Association Provenance
rs216906804 5 T>I No EVA
rs256867717 18 A>G No EVA
rs3389056768 29 S>C No EVA
rs255769960 31 S>N No EVA
rs253489098 38 A>S No EVA
rs229914538 39 R>S No EVA
rs3389042130 42 Y>F No EVA
rs265269603 56 G>V No EVA
rs245174061 59 A>V No EVA
rs3389059359 75 G>E No EVA
rs3389056757 80 V>M No EVA
rs3389070045 84 E>G No EVA
rs3389038038 101 C>Y No EVA
rs1132727432 113 Y>* No EVA
rs1131802262 118 E>* No EVA
rs3389064238 120 L>F No EVA
rs36776470 132 T>A No EVA
rs3389061904 135 V>I No EVA
rs3389069411 164 H>Q No EVA
rs3389063994 199 Y>C No EVA
rs36340082 205 R>L No EVA
rs3389059229 208 R>W No EVA
rs37997882 245 T>A No EVA
rs3389069446 268 A>S No EVA
rs3389055085 279 K>E No EVA
rs3389038006 300 T>A No EVA
rs3389006958 328 T>N No EVA
rs3389064210 330 R>C No EVA
rs3389038049 353 V>A No EVA
rs3400442412 362 Y>FLALIVCK* No EVA
rs3389065431 365 A>V No EVA
rs3389070022 372 M>V No EVA
rs3389065426 375 K>N No EVA
rs3400582716 385 S>T No EVA
rs3389069979 462 G>V No EVA
rs3389042090 523 C>S No EVA
rs250673284 573 N>H No EVA
rs3389069987 581 Y>C No EVA
rs3389056750 605 D>V No EVA
rs3389064213 631 Y>N No EVA
rs3389055012 633 L>I No EVA
rs3389064235 641 C>R No EVA
rs3389007006 643 L>* No EVA
rs3389048552 680 Q>* No EVA
rs3389006994 687 Y>* No EVA
rs37219793 698 R>W No EVA
rs3389056772 700 K>* No EVA
rs213434432 704 K>R No EVA
rs3400359240 707 K>* No EVA
rs33755021 711 G>S No EVA
rs3389056794 740 V>I No EVA
rs3389037980 749 V>L No EVA
rs3389061905 750 I>T No EVA
rs3389059237 753 K>R No EVA
rs3389028235 756 N>I No EVA
rs580518625 767 F>L No EVA
rs3389069956 770 D>V No EVA
rs234422207 796 H>Y No EVA
rs235708318 842 V>M No EVA
rs3389069448 865 E>D No EVA
rs3389069445 938 R>* No EVA
rs252440359 951 S>Y No EVA
rs3389056811 963 E>G No EVA
rs228160436 966 N>S No EVA
rs252284092 974 T>S No EVA
rs3389042061 995 G>* No EVA
rs3399918552 1017 T>N No EVA
rs3400540568 1022 S>T No EVA
rs3389064219 1029 S>L No EVA
rs3389065466 1068 G>A No EVA
rs3389065435 1073 C>Y No EVA
rs3412852274 1091 P>S No EVA
rs236335599 1093 F>L No EVA
rs3389065465 1094 I>M No EVA
rs3389048548 1101 T>S No EVA
rs3389069970 1153 L>I No EVA
rs3389038040 1160 M>V No EVA
rs108919419 1186 P>H No EVA
rs261097195 1189 A>V No EVA
rs3400494650 1205 D>V No EVA
rs3399892615 1207 L>F No EVA
rs3400442437 1209 E>Q No EVA
rs3400582678 1209 E>V No EVA
rs3400359341 1210 E>V No EVA
rs3400253171 1212 K>N No EVA
rs29590417 1217 Y>H No EVA
rs3389065434 1228 F>L No EVA
rs3389065448 1264 P>L No EVA
rs3389059356 1306 A>G No EVA
rs3389059169 1342 L>M No EVA

No associated diseases with Q6ZPR6

6 regional properties for Q6ZPR6

Type Name Position InterPro Accession
domain BTB/POZ domain 560 - 745 IPR000210-1
domain BTB/POZ domain 762 - 872 IPR000210-2
repeat Regulator of chromosome condensation, RCC1 142 - 195 IPR000408-1
repeat Regulator of chromosome condensation, RCC1 195 - 247 IPR000408-2
repeat Regulator of chromosome condensation, RCC1 247 - 302 IPR000408-3
repeat Ankyrin repeat 33 - 117 IPR002110

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Membrane ; Peripheral membrane protein
  • Translocates to the plasma membrane upon IgM stimulation
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.

2 GO annotations of molecular function

Name Definition
protein kinase binding Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
protein tyrosine kinase inhibitor activity Stops, prevents or reduces the activity of a protein tyrosine kinase.

2 GO annotations of biological process

Name Definition
negative regulation of protein phosphorylation Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.
release of sequestered calcium ion into cytosol The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDAATPDCTS KCRSLKHALD VLSVVTKGSE SQIKSFLARY CYNAATVKDA FGRNAGHLAS
70 80 90 100 110 120
SCGKKGVLDW LIEKGVDLLV KDKESGWTAL HRSVFYGHID CVWSLLKHGV SLYMQDKEGL
130 140 150 160 170 180
SPLDLLMKDR PTHVVFKDTD PTEVYTWGDN TNFTLGHGSQ NSKHHPELLD LFSRSGVYVK
190 200 210 220 230 240
QVVLCKFHSV FLSQKGQVYT CGHGRGGRLG HGDEQTCLVP RLVEGLSGHN CSQVAAAKDH
250 260 270 280 290 300
TVVLTDDGCV YTFGLNMFHQ LGIIPPPASC NVPRQIQAKY LKGRTIIGVA AGRFHTVLWT
310 320 330 340 350 360
REAVYTLGLN GGQLGHLLDP NGEKCVTTPR QVSALHHKDI AVSLVAASDG ATVCVTTRGD
370 380 390 400 410 420
IYLLADYQCK KMATKQLNLK KVLVSGGCME YKVDPEHLTE NGGQKICVLA MDGAGRVFCW
430 440 450 460 470 480
RSISSSLKQC RWAYPRQVSI SDIALNRNEI LFVTQDGEGF KGKWFEDKRK NSEKKADILP
490 500 510 520 530 540
NLHHSSSDVS CVPDTNSVYE RIRLEKLPFA HRAVSVSTDP SGCNFAILQS DPKTSLYEIP
550 560 570 580 590 600
VVSSSSFFEE FGKLLRETDE MDSFHDVTFQ VGNRHFPAHK YILAVRSDFF QKLFLSDGSS
610 620 630 640 650 660
LELTDVYQKD EDAAGCHLFV VEKVHPDLFE YLLQFMYTDT CDLLTHGFKP RMIVKRKAED
670 680 690 700 710 720
CEGSPDSHLH TVNCHVDDKQ KSAFEVYRSN QAHTLSERQK SKPKSSKKGK GVGDDDPVRM
730 740 750 760 770 780
LQSVAKKFGL SNLSSRLEGV RLENEKINVI AKKTGNKLKL SQKKCSFLYD VTMKSVDGKE
790 800 810 820 830 840
FSCHKCVLCA RLEYFHSMLS RSWIEASSCA ALEMPIQSEI LKVILDYLYT DEAVVIKESQ
850 860 870 880 890 900
NVDFVCSVLV VADQLLITRL KEICEVALTE NLTLKNAAML LEFAALYNAG QLKLSCLQFI
910 920 930 940 950 960
GLNMAALLEA RSLDVLSEDV LKDLSIFYRK MIPAMERRVI TPYQDGPDIS SMQVEDGEVF
970 980 990 1000 1010 1020
FKEEINMEPN YSETMFKKAK TRAKKKPRKR SDSSGGYTLS DVIQSPPSAG LLKSAKTNSV
1030 1040 1050 1060 1070 1080
ESLPELLTSD SEGSYAGVAS PRDLQSPDFT AGFHSDKVEG KAKPYVNGIP PPCTREDVKP
1090 1100 1110 1120 1130 1140
WEKSPTTKSA PQFIPSNRVD TAASSSWLAG SCSPVSPPVV DLRTIMETEE NRQKYGAAPK
1150 1160 1170 1180 1190 1200
SNLGKIISHG IKLSQKQRKM IALTTKENNS GTNSMEAILT APSKSPKPAN AWAPLHSPLS
1210 1220 1230 1240 1250 1260
RSFRDFLLEE KKPVPGYGSG DHVKKVCFKG TENSPALNVA RCSTHGTPGL ESNHVSDFPL
1270 1280 1290 1300 1310 1320
LDSPNPWQSS SLAASPAVAP VTFASIVEEE RQQEAALIRS REKPLALIQV EEHAIQDLLV
1330 1340 1350
FYEAFGNPEE FVVVERAPQG PLAVPMWNKH GC