AiPD: Autoinhibited Protein Database

Gene name	Zfyve28 (Kiaa1643, Lst2)
Protein name	Lateral signaling target protein 2 homolog
Names	Zinc finger FYVE domain-containing protein 28
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:231125
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

350-432 (Predicted disordered autoinhibitory region) PR

350-432 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q6ZPK7-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388751168	41	D>V	No	EVA
rs3388737993	57	R>H	No	EVA
rs3395063762	82	R>Q	No	EVA
rs3388755739	91	E>K	No	EVA
rs3388748820	95	D>E	No	EVA
rs3388744676	99	G>C	No	EVA
rs3388749873	151	N>S	No	EVA
rs3412613783	158	R>L	No	EVA
rs3388754769	202	V>E	No	EVA
rs3388756231	205	A>V	No	EVA
rs3388737995	212	T>I	No	EVA
rs3388758633	252	D>E	No	EVA
rs264799116	299	D>E	No	EVA
rs3395377001	306	L>M	No	EVA
rs3395258769	306	L>R	No	EVA
rs3388727932	316	P>S	No	EVA
rs3388755770	320	L>F	No	EVA
rs3388749823	364	S>N	No	EVA
rs3388749870	395	D>E	No	EVA
rs3388738017	398	E>V	No	EVA
rs38410382	423	E>D	No	EVA
rs3388761030	451	E>D	No	EVA
rs3388756266	460	E>G	No	EVA
rs237254554	464	I>R	No	EVA
rs38761932	470	M>V	No	EVA
rs3388727919	502	H>Y	No	EVA
rs3388749865	542	P>S	No	EVA
rs3388754741	549	D>V	No	EVA
rs3388756261	552	H>Q	No	EVA
rs3388738034	565	S>T	No	EVA
rs3388755319	570	G>W	No	EVA
rs3388749812	604	K>E	No	EVA
rs3388756220	614	D>G	No	EVA
rs3388749821	620	D>E	No	EVA
rs3388757125	632	Q>H	No	EVA
rs259747647	654	A>E	No	EVA
rs3395371042	678	K>T	No	EVA
rs3411105600	681	V>L	No	EVA
rs3395373417	682	V>A	No	EVA
rs3395373371	682	V>I	No	EVA
rs3395377017	683	S>R	No	EVA
rs3395427337	683	S>T	No	EVA
rs3388727984	736	S>Y	No	EVA
rs3388740604	790	L>P	No	EVA
rs3388756271	798	R>L	No	EVA
rs3388747459	800	A>V	No	EVA
rs3388740642	807	L>Q	No	EVA
rs3388761014	825	D>N	No	EVA
rs3388748754	852	R>S	No	EVA

Type	Name	Position	InterPro Accession
domain	FYVE zinc finger	827 - 896	IPR000306
domain	Zinc finger, FYVE-related	835 - 891	IPR017455
domain	Lateral signaling target protein 2, FYVE domain	828 - 892	IPR043269

		Description
EC Number
Subcellular Localization	Cytoplasm, cytosol Early endosome membrane	Localizes to early endosome membrane in absence of Lys-87 monoubiquitination Localizes to cytosol when monoubiquitinated (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
early endosome membrane	The lipid bilayer surrounding an early endosome.

Name	Definition
metal ion binding	Binding to a metal ion.
phosphatidylinositol-3-phosphate binding	Binding to phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position.

Name	Definition
negative regulation of epidermal growth factor receptor signaling pathway	Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
negative regulation of epidermal growth factor-activated receptor activity	Any process that stops, prevents, or reduces the frequency, rate or extent of EGF-activated receptor activity.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins