Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6YNB6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6YNB6-F1 | Predicted | AlphaFoldDB |
No variants for Q6YNB6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6YNB6 | |||||
No associated diseases with Q6YNB6
4 regional properties for Q6YNB6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) | 243 - 421 | IPR002314 |
| domain | Aminoacyl-tRNA synthetase, class II | 199 - 431 | IPR006195 |
| domain | Serine-tRNA synthetase, type1, N-terminal | 1 - 109 | IPR015866 |
| domain | Serine-tRNA ligase catalytic core domain | 122 - 438 | IPR033729 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| receptor complex | Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| follicle-stimulating hormone receptor activity | Combining with follicle-stimulating hormone to initiate a change in cell activity. |
| G protein-coupled receptor activity | Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to follicle-stimulating hormone stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a follicle-stimulating hormone stimulus. |
| follicle-stimulating hormone signaling pathway | A G protein-coupled receptor signaling pathway initiated by follicle-stimulating hormone binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. |
| G protein-coupled receptor signaling pathway | The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. |
| positive regulation of ERK1 and ERK2 cascade | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. |
| positive regulation of phosphatidylinositol 3-kinase signaling | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade. |
| regulation of protein kinase A signaling | Any process that modulates the rate, frequency, or extent of protein kinase A signaling. PKA signaling is the series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAFLWISFLV | FLGSGSGCHH | RICHCSDRVF | ICQESKVTEI | PSDIPRNTVE | MRFVLTKLQV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IPRGAFSGFR | DLEKIEISQN | DALEVIEADV | FSNLPKLHEI | RIEKANNLVL | IDPEAFWNLP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NLRYLLISNT | GIKHLPAVYK | IQSHQKVLLD | IQDNINIRTI | ERNSFAGLSS | ESEILWLNKN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GIQEIQNQAF | NGTQLDELNL | SDNINLEDLP | NGIFQGANGP | VILDISRTRI | HSLPSDGLKN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LKKLKARSAY | NFKTLPNLDK | FAELVEANLT | YPSHCCAFAN | WRRQAFELHP | ICNKSFVRQD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SDDLAMDWGH | RRRSVEEEYV | SNLDKGFDIT | DTELDYDLCN | EVVDVACSPK | PDAFNPCEDI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| MGYNFLRVLI | WFISILSITG | NIVVLVILIT | SQYKLTVPRF | LMCNLAFADL | CIGIYLLLIA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SVDIHTKSQY | HNYAIDWQTG | AGCDAAGFFT | VFASELSVYT | LTAITLERWH | TITYAMQLDR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KVRLRHAASI | MLIGWIFAFS | VALLPIFGVS | SYMKVSICLP | MDIDSPLSQF | YVISLLVLNV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LASVIICTCY | THIYFTVRNP | NIISSTSDAK | IAKRMAMLIF | TDFLCMAPIS | FFAISASVKM |
| 610 | 620 | 630 | 640 | 650 | 660 |
| PLITVSKSKI | LLVLFYPINS | CANPFLYAVF | TKTFRRDFFI | LLSKFGCCEM | QAQIYRTETS |
| 670 | 680 | 690 | |||
| STVHSSHPRN | GQCPLMAKSN | SGAVYKLVPL | NHLS |