Q6XQH7

PR
Gene name
L
Protein name
RNA-directed RNA polymerase L
Names
Protein L, Large structural protein, Replicase, Transcriptase
Species
Oliveros mammarenavirus (isolate Mouse/Argentina/RIID 3229/1990) (OLVV)
KEGG Pathway
vg:5848321
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

900-976 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

0 structures for Q6XQH7

Entry ID Method Resolution Chain Position Source

No variants for Q6XQH7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6XQH7

No associated diseases with Q6XQH7

2 regional properties for Q6XQH7

Type Name Position InterPro Accession
domain RNA-directed RNA polymerase, negative-strand RNA virus 1176 - 1371 IPR007099
domain RNA endonuclease, cap-snatching 8 - 173 IPR026382

Functions

Description
EC Number
Subcellular Localization
  • Virion
  • Host cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
host cell cytoplasm The cytoplasm of a host cell.
virion component Any constituent part of a virion, a complete fully infectious extracellular virus particle.

3 GO annotations of molecular function

Name Definition
hydrolase activity Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
nucleotide binding Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
RNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time.

3 GO annotations of biological process

Name Definition
cap snatching A transcription initiation process during which a nucleotide sequence between 10 and 20 nucleotides in size is cleaved from the 5' end of host mRNAs by a viral RNA-dependent polymerase. The capped leader sequence obtained is subsequently used to prime transcription on the viral genome, which ultimately leads to the synthesis of capped, translatable viral mRNAs.
negative stranded viral RNA replication A viral genome replication process where the template genome is negative stranded, single stranded RNA ((-)ssRNA).
RNA-templated viral transcription A transcription process that uses viral RNA as a template.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDESVSSLFD LLRKHFPAKE EISRQITVVT SQTEMRMILT EGFKLLSLLI ELDSCEVNNC
70 80 90 100 110 120
SHNKEDLTVE AILSKDNILT IALPRIVPDG YSLYGNVLIL LETFVRVNPS SFEQKYNQDM
130 140 150 160 170 180
NKLLSLKNDL QLCGITLVPL VDGRTNYYNK FVDDWVIERF RWLLTQIMKV AKESGESIEE
190 200 210 220 230 240
LEYQRLVTSL SKLENQSLGF ENIIKMPQTG IDYRDKLKAR MFANLSNKMK ESEINQSLLS
250 260 270 280 290 300
LKLAFDEAYN DESHLKKFQK TNKEDLIFKL GQQINLSDEK LSCMSCSSKL FSIVSSITQN
310 320 330 340 350 360
RDKLDSHVMS VSNAKLWHHE SGIANVNEYL RILSVCNKIK SAKILNTRRN TLLFLDMIVL
370 380 390 400 410 420
NFIDDCWKND PTILFQFKKS GLLVGQLAYF VNDRFFDLLL LKELLSKKLK SSPDWIHRCL
430 440 450 460 470 480
CNIRKQEFFD ISGVEFWIRQ PDYESVEELC CALEPVKPKL QYCRDEDNHE NHKLDLADKD
490 500 510 520 530 540
NYFTCLSVLS SVCLGLVNSM KTSFTSKMVI NEKSPNNFYG EVELKECYCQ RFYVSDEITG
550 560 570 580 590 600
LLFYQKTGEK SRCYSIGVTM HGSYKYIGSF YCDPKRFFLP IFSQVVLFQM TEEMMSWLPE
610 620 630 640 650 660
EPSYKEPVVA NLRKLILMLL CNPSKRNQNF LQGMRYFIMA YVNQFHSVEL MSKLEVPCKS
670 680 690 700 710 720
VSEECVQKLT YNLLVDVLTK GDVNEHMTRK FKFCLNVSYL CHLITKETPD RLTDQIKCFE
730 740 750 760 770 780
KFLEPKLKFK SVIINPNLTG DLTEEQEEQL LNSIEKLLGK GLQDINDSSE PGISRELLSM
790 800 810 820 830 840
CISAFNRDLL RVNGKLKNDP YKPNFTSTAL DLSSNKSVVI PKLDELGNPI SKYDYELLVS
850 860 870 880 890 900
SCIASMAESF KTKGKYKLDP TSQEFLILKN LYSLMSKSKR DDHMKDSEDS KQNLSSDLEN
910 920 930 940 950 960
LSEEQVLILE QVKRDVNLAL SKMRETKLKE KTEARQSSSG SSLKNQQKRQ AELQERLSEL
970 980 990 1000 1010 1020
WSEFMCMKII TVEVSLHEIK DFDPDLIDHT TLKSMLDKLY NSDLASEFFL EEILNPCPLE
1030 1040 1050 1060 1070 1080
FLVKNMTTSS YLEGDLFECF KYTLISAGFD QKLGTYEHKN KTRLGFKYEA LKVREEGRMS
1090 1100 1110 1120 1130 1140
LRESNSEAIA RRLDRSVFSN SALRNLCFYS DESPISYSHV SSDTGKLKFG LSYKEQVGSN
1150 1160 1170 1180 1190 1200
RELYVGDLNT KLMTRLIEDF SESVVSNMNY SCLNSEKEFE RSVMEMKMSV NLGEMNFSLD
1210 1220 1230 1240 1250 1260
HSKWGPYMSP VIFAAFLQGL KLEQGSMCTP VSVEPIITLL SWHIHKVVEV PYNVIHAYMT
1270 1280 1290 1300 1310 1320
GMIKRQLGLM SPGESSKTEA FIHRLLVDER EPLSHVMSVL DMGQGILHNT SDLYGLVTEQ
1330 1340 1350 1360 1370 1380
FINYAMRILY DVSMTSFTSS DDQITMVKLN EDLKDMDNPE VISNWERMIN FHTFISSKFN
1390 1400 1410 1420 1430 1440
KFVSPKTVIG TFAAEFKSRF FVWGEEVPLL TKFVSAALHN IKCKTPIQLS ETIDTISDQC
1450 1460 1470 1480 1490 1500
VANGVSVEIV SCISNRTNKL VRYSGFPDNP FLSVENMDVK DWVDGNRGYR LQRNIESHLE
1510 1520 1530 1540 1550 1560
VDGCTRFVRQ AARKVFRNIK SGKIMEQTLV NLVQEDGDKA FQGFMKSVDV SDDDIKLLQN
1570 1580 1590 1600 1610 1620
FRWINLSTHG DMRLVLRTKL MSSRRIIEQE EIPGLIKSIQ SKLSKNFVRG AKRILADSIN
1630 1640 1650 1660 1670 1680
KSAFQSSIAS GFIGFCKSMG SKCVRLGGGG FGYIKDIKNK VKHDCLCDIC FRWRGCVYCP
1690 1700 1710 1720 1730 1740
SSCADVFEFS RPLMWDYFTL VLTNACELGE WVFEDVEIPK DLYFLRNPNL FWLVKPRVTC
1750 1760 1770 1780 1790 1800
QLEERLGLSH ILQSIRKNYP TLFETHLSPF MSDFMVGKTL GSLTVKFLDL CVALDLANEN
1810 1820 1830 1840 1850 1860
LGITKHFLKE RRHEIYVVKQ DESSQSHIRN VKGIESSVEL NSMQVCNNFL TQLLMSSFIQ
1870 1880 1890 1900 1910 1920
PLVLTSSVFK KFNWFAEVLC LKTEEEVCLK QLTDFVLQVK KFNVDRAMHI EDLSAGYISS
1930 1940 1950 1960 1970 1980
TINVTSFSLS VPTFLECVDS DFINKEGNEP GDFKDLLSSE FTKDTLTLDF CIQVSHIKRS
1990 2000 2010 2020 2030 2040
VKFNVKRTLV YTLAVRTQIE KKIILEAIGT DDQISLIVSE LDLFCSGHTG NHFVLDAAPL
2050 2060 2070 2080 2090 2100
IYSEPLIAGS LKFDLLSMLR DQELSLTSSE KMPTFNFDFS SQKHHIVNKF AYKLVGPSVY
2110 2120 2130 2140 2150 2160
DEPLVLNKGI VYSGERKLTS LGVDVSGERI VQAMGELDSI SEQELFLTNL WGYSKETDIK
2170 2180 2190 2200 2210 2220
VRIIQDNLKI LTDNYFVQLK NSLKTFAEWL NLGNYMLCYS KTLDTIMISD VSGRIKLKGV
2230
ICRKLIEDEV MEVE