Q6WI70

PR
Gene name
43
Protein name
DNA-directed DNA polymerase
Names
Gene product 43, Gp43
Species
Vibrio phage KVP40 (isolate Vibrio parahaemolyticus/Japan/Matsuzaki/1991) (KVP40) (Bacteriophage KVP40)
KEGG Pathway
vg:2545927
EC number
2.7.7.7: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

444-529 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

0 structures for Q6WI70

Entry ID Method Resolution Chain Position Source

No variants for Q6WI70

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6WI70

No associated diseases with Q6WI70

3 regional properties for Q6WI70

Type Name Position InterPro Accession
domain DNA-directed DNA polymerase, family B, exonuclease domain 97 - 274 IPR006133
domain DNA-directed DNA polymerase, family B, multifunctional domain 350 - 721 IPR006134
conserved_site DNA-directed DNA polymerase, family B, conserved site 580 - 588 IPR017964

Functions

Description
EC Number 2.7.7.7 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

5 GO annotations of molecular function

Name Definition
3'-5' exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.
metal ion binding Binding to a metal ion.
nucleotide binding Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.

2 GO annotations of biological process

Name Definition
bidirectional double-stranded viral DNA replication A viral DNA replication process where replication occurs in both directions from the starting point. This creates two replication forks, moving in opposite directions.
DNA replication The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTIYTSIERI GSNLCERYID DDGFEHMRKV KYEPTLFIHC NEETGYKDIY GRNCRPKMFD
70 80 90 100 110 120
TMGEASKYIK ETKQFNEVLG MDDFIVTYIS DVYKQREFDM SRIRIANIDI ETPSVEFPEA
130 140 150 160 170 180
AHAPVPITSI GHYDNIDDKF YVYGIPSNTE WKRESSIVKP ELLEKTVYIR CATEKELLVK
190 200 210 220 230 240
YLQFWREKTP AIVTGWNIES FDMPYIVNRY KNLFGEKVMN SLSPWGKVQV STTVNDYGQE
250 260 270 280 290 300
ICKVNILGVS ELDYLQLYKK FTYVTRPSYR LDYIGEVELD EKKVEFEQAN YLEFYEQDYQ
310 320 330 340 350 360
NFIDYQIQDV NLVKRLDEKL QLMLLTISLA YYAGINYQTV LGTIKPWDAI IFNSLKAEKK
370 380 390 400 410 420
VVPMMRSHEG GRFMGAFVKA PQVGYHRGIG SFDLTSLYPS IIRECNISPE TIVGQLDYEG
430 440 450 460 470 480
SLEDRIDKIV EGLITFPADE LSNSANGMQY RKDVRGVIPV EIEKVFFQRK ANKKKAFEYE
490 500 510 520 530 540
QQAIDIQKQM DEQGETPELR AAYEEAKHQA KIYDVQQMAR KILINSLYGA LGNEYFRFYD
550 560 570 580 590 600
LRNAEAVTAY GQLAIKWVAR DVNIWLNKVC KTTDKDYVIY GDTDSIYVNF DPLLELTGIN
610 620 630 640 650 660
KLEGDDYTDK FAKVCETVET KVINPSYEAL HKYMNTYERQ MFMDREVLAR TGFFIAKKRY
670 680 690 700 710 720
ALDVQDNEGI RKPKLKIMGI ETQRSSTPPL CQKGLKEAIR LILQEGEAKL QEFVKGYEKE
730 740 750 760 770 780
FKAAPYQEVS FVSSANNMNK YSDDKGNPGK GCPGHVKGAL YYNKLAEEHG FDKINEGDKI
790 800 810 820 830 840
AVVFLTRNKH GIDRIAYPSG GKLPEAISYL IDHVDYNRLY EDKFIKPLSA ISEAIKFDYK
KTITLESFFG