Q6WB93

PR
Gene name
L
Protein name
RNA-directed RNA polymerase L
Names
Protein L, Large structural protein, Replicase, Transcriptase
Species
Human metapneumovirus (strain CAN97-83) (HMPV)
KEGG Pathway
EC number
2.1.1.375: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

581-650 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for Q6WB93

Entry ID Method Resolution Chain Position Source
4UCJ X-ray 326 A A/B 1600-2005 PDB
6U5O EM 370 A L 1-2005 PDB
8FPJ EM 274 A A 1-2005 PDB

No variants for Q6WB93

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6WB93

No associated diseases with Q6WB93

4 regional properties for Q6WB93

Type Name Position InterPro Accession
domain Mononegavirales RNA-directed RNA polymerase catalytic domain 15 - 1105 IPR014023
domain Mononegavirus L protein 2-O-ribose methyltransferase 1662 - 1852 IPR025786
domain Mononegavirales mRNA-capping domain V 1127 - 1332 IPR026890
domain RNA-directed RNA polymerase L, C-terminal 1210 - 2001 IPR039736

Functions

Description
EC Number 2.1.1.375 Methyltransferases
Subcellular Localization
  • Virion
  • Host cytoplasm
  • Localizes in cytoplasmic inclusion bodies
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
host cell cytoplasm The cytoplasm of a host cell.
virion component Any constituent part of a virion, a complete fully infectious extracellular virus particle.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
metal ion binding Binding to a metal ion.
mRNA (guanine-N7-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA. m7G(5')pppR-RNA is mRNA containing an N7-methylguanine cap; R may be guanosine or adenosine.
RNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDPLNESTVN VYLPDSYLKG VISFSETNAI GSCLLKRPYL KNDNTAKVAI ENPVIEHVRL
70 80 90 100 110 120
KNAVNSKMKI SDYKVVEPVN MQHEIMKNVH SCELTLLKQF LTRSKNISTL KLNMICDWLQ
130 140 150 160 170 180
LKSTSDDTSI LSFIDVEFIP SWVSNWFSNW YNLNKLILEF RREEVIRTGS ILCRSLGKLV
190 200 210 220 230 240
FIVSSYGCIV KSNKSKRVSF FTYNQLLTWK DVMLSRFNAN FCIWVSNSLN ENQEGLGLRS
250 260 270 280 290 300
NLQGMLTNKL YETVDYMLSL CCNEGFSLVK EFEGFIMSEI LRITEHAQFS TRFRNTLLNG
310 320 330 340 350 360
LTDQLTKLKN KNRLRVHSTV LENNDYPMYE VVLKLLGDTL RCIKLLINKN LENAAELYYI
370 380 390 400 410 420
FRIFGHPMVD ERDAMDAVKL NNEITKILRL ESLTELRGAF ILRIIKGFVD NNKRWPKIKN
430 440 450 460 470 480
LKVLSKRWTM YFKAKNYPSQ LELSEQDFLE LAAIQFEQEF SVPEKTNLEM VLNDKAISPP
490 500 510 520 530 540
KRLIWSVYPK NYLPETIKNR YLEETFNASD SLKTRRVLEY YLKDNKFDQK ELKSYVVRQE
550 560 570 580 590 600
YLNDKEHIVS LTGKERELSV GRMFAMQPGK QRQIQILAEK LLADNIVPFF PETLTKYGDL
610 620 630 640 650 660
DLQRIMEIKS ELSSIKTRRN DSYNNYIARA SIVTDLSKFN QAFRYETTAI CADVADELHG
670 680 690 700 710 720
TQSLFCWLHL IVPMTTMICA YRHAPPETKG EYDIDKIEEQ SGLYRYHMGG IEGWCQKLWT
730 740 750 760 770 780
MEAISLLDVV SVKTRCQMTS LLNGDNQSID VSKPVKLSEG LDEVKADYRL AVKMLKEIRD
790 800 810 820 830 840
AYRNIGHKLK EGETYISRDL QFISKVIQSE GVMHPTPIKK VLRVGPWINT ILDDIKTSAE
850 860 870 880 890 900
SIGSLCQELE FRGESIIVSL ILRNFWLYNL YMHESKQHPL AGKQLFKQLN KTLTSVQRFF
910 920 930 940 950 960
EIKRENEVVD LWMNIPMQFG GGDPVVFYRS FYRRTPDFLT EAISHVDILL KISANIKNET
970 980 990 1000 1010 1020
KVSFFKALLS IEKNERATLT TLMRDPQAVG SERQAKVTSD INRTAVTSIL SLSPNQLFSD
1030 1040 1050 1060 1070 1080
SAIHYSRNEE EVGIIAENIT PVYPHGLRVL YESLPFHKAE KVVNMISGTK SITNLLQRTS
1090 1100 1110 1120 1130 1140
AINGEDIDRA VSMMLENLGL LSRILSVVVD SIEIPIKSNG RLICCQISRT LRETSWNNME
1150 1160 1170 1180 1190 1200
IVGVTSPSIT TCMDVIYATS SHLKGIIIEK FSTDRTTRGQ RGPKSPWVGS STQEKKLVPV
1210 1220 1230 1240 1250 1260
YNRQILSKQQ REQLEAIGKM RWVYKGTPGL RRLLNKICLG SLGISYKCVK PLLPRFMSVN
1270 1280 1290 1300 1310 1320
FLHRLSVSSR PMEFPASVPA YRTTNYHFDT SPINQALSER FGNEDINLVF QNAISCGISI
1330 1340 1350 1360 1370 1380
MSVVEQLTGR SPKQLVLIPQ LEEIDIMPPP VFQGKFNYKL VDKITSDQHI FSPDKIDMLT
1390 1400 1410 1420 1430 1440
LGKMLMPTIK GQKTDQFLNK RENYFHGNNL IESLSAALAC HWCGILTEQC IENNIFKKDW
1450 1460 1470 1480 1490 1500
GDGFISDHAF MDFKIFLCVF KTKLLCSWGS QGKNIKDEDI VDESIDKLLR IDNTFWRMFS
1510 1520 1530 1540 1550 1560
KVMFEPKVKK RIMLYDVKFL SLVGYIGFKN WFIEQLRSAE LHEIPWIVNA EGDLVEIKSI
1570 1580 1590 1600 1610 1620
KIYLQLIEQS LFLRITVLNY TDMAHALTRL IRKKLMCDNA LLTPISSPMV NLTQVIDPTT
1630 1640 1650 1660 1670 1680
QLDYFPKITF ERLKNYDTSS NYAKGKLTRN YMILLPWQHV NRYNFVFSST GCKVSLKTCI
1690 1700 1710 1720 1730 1740
GKLMKDLNPK VLYFIGEGAG NWMARTACEY PDIKFVYRSL KDDLDHHYPL EYQRVIGELS
1750 1760 1770 1780 1790 1800
RIIDSGEGLS METTDATQKT HWDLIHRVSK DALLITLCDA EFKDRDDFFK MVILWRKHVL
1810 1820 1830 1840 1850 1860
SCRICTTYGT DLYLFAKYHA KDCNVKLPFF VRSVATFIMQ GSKLSGSECY ILLTLGHHNS
1870 1880 1890 1900 1910 1920
LPCHGEIQNS KMKIAVCNDF YAAKKLDNKS IEANCKSLLS GLRIPINKKE LDRQRRLLTL
1930 1940 1950 1960 1970 1980
QSNHSSVATV GGSKIIESKW LTNKASTIID WLEHILNSPK GELNYDFFEA LENTYPNMIK
1990 2000
LIDNLGNAEI KKLIKVTGYM LVSKK