Q6UY61

PR
Gene name
L
Protein name
RNA-directed RNA polymerase L
Names
Protein L, Large structural protein, Replicase, Transcriptase
Species
Sabia mammarenavirus (isolate Human/Brasil/SPH114202/1990) (SABV) (Sabi mammarenavirus)
KEGG Pathway
vg:3077250
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

890-974 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

0 structures for Q6UY61

Entry ID Method Resolution Chain Position Source

1 variants for Q6UY61

Variant ID(s) Position Change Description Diseaes Association Provenance
965 T>A No

No associated diseases with Q6UY61

2 regional properties for Q6UY61

Type Name Position InterPro Accession
domain RNA-directed RNA polymerase, negative-strand RNA virus 1176 - 1371 IPR007099
domain RNA endonuclease, cap-snatching 8 - 173 IPR026382

Functions

Description
EC Number
Subcellular Localization
  • Virion
  • Host cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
host cell cytoplasm The cytoplasm of a host cell.
virion component Any constituent part of a virion, a complete fully infectious extracellular virus particle.

3 GO annotations of molecular function

Name Definition
hydrolase activity Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
nucleotide binding Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
RNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time.

3 GO annotations of biological process

Name Definition
cap snatching A transcription initiation process during which a nucleotide sequence between 10 and 20 nucleotides in size is cleaved from the 5' end of host mRNAs by a viral RNA-dependent polymerase. The capped leader sequence obtained is subsequently used to prime transcription on the viral genome, which ultimately leads to the synthesis of capped, translatable viral mRNAs.
negative stranded viral RNA replication A viral genome replication process where the template genome is negative stranded, single stranded RNA ((-)ssRNA).
RNA-templated viral transcription A transcription process that uses viral RNA as a template.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQDPLLGTLS ELKDLVRKTI PDVIELAYQK DALLSQVHPR SVLIEGFKLL SLLVELESCK
70 80 90 100 110 120
VNACHHNYEQ KFIDVILSDG GILCPTLPKV VPDGYNLMGK TLILLETFVR VNPDDFEKKW
130 140 150 160 170 180
KADMSKLISL KTDLGKIGVT LVPVVDGRSN YNTSFVSDWT TERLRWLLIE VLKGMKTTSE
190 200 210 220 230 240
LEIEEQEYHR LIHSLAKTNN QSLGFENLEC LKRNMLSYDQ LLDSSLLVGV KNDVKESKVM
250 260 270 280 290 300
EELIRLKIWY KSEVYEKGLG KFVKTDKKVL LSQLITLGSH EENDSLDCAF CSSRILELCF
310 320 330 340 350 360
KLSVKMHEDV LTRGLNLDGT KTLHSSVQSY LNVLSMCNKI KGSKIFNTRR NTLLFLDLIM
370 380 390 400 410 420
LNFVVDEMVK DSTVIRNLKN AGLIVGQMIL LVNDRVLDIL TANKLIRQKL TTNEKWLSIC
430 440 450 460 470 480
SSVLKRYDLE LWEKLCYLIR VPDFNELFQL AKELVSDRPM MRYSVHKAEE RQCCHKAMEN
490 500 510 520 530 540
FTDDDFKIML KALSHLSLGL INSMKTSFSS RLLINERDYS RYFGNVRLRE CYIQRFPITN
550 560 570 580 590 600
NIIGLLFYQK TGERSRCYSL YIAENGELTE IGSFYCDPKR YFVPIFSEAV ITSMCEEMIN
610 620 630 640 650 660
WLNFDSELVR IVSTQLKTLM LLLLCSPSKR NQTFLQGLRY FIMAYVNQAH HIDLMSKLAV
670 680 690 700 710 720
ECKSSSEIQL QRLCVRLFVS ILSGDNEIEY GFTRRFKFLL NISYLCHFIT KETPDRLTDQ
730 740 750 760 770 780
IKCFEKFLEP KLKFNSVIVN PSLNGTLTES QEHQMISSID RFFSKELLDQ SDVKEPGVSR
790 800 810 820 830 840
ELLGYCVSLF NRGKLRVSGD LKVDPFRPTF TSTALDISSN KSVVVPKLDE LGNIVDKYNK
850 860 870 880 890 900
QLMVSSCVTS LVEMFKTKGR YNLDPDSIDF LVLKNLTNLV SANVPQEKSQ EELSTLYEAL
910 920 930 940 950 960
TEDQISAFEQ VRDEVQLALH KMKSSDAREE RLQDPKRNEK NASKGKILES LWSPHQVNRA
970 980 990 1000 1010 1020
IKNETSIHEI KDFDPDILDS HLVEKLCHEV YNSSQKSLFF LDEPLKSVPL EMLLINLTTI
1030 1040 1050 1060 1070 1080
AYEEEEFFEC FKYLLIQGDF DQKLGTYEHK SRSRLGLSSE ALKVQENARV STRESNAEAI
1090 1100 1110 1120 1130 1140
AKKLDRTFFT SAALRNLCFY SEDSPTEFTS VSTNTGNLKF GLSYKEQVGS NRELYVGDLN
1150 1160 1170 1180 1190 1200
TKLMTRLVED FSEVVTGSMR FSCLNSEKEF ERAICDMKMA VNNGDFSLSM DHSKWGPHMS
1210 1220 1230 1240 1250 1260
PALFFTFLAN LNLTEPKSRT RLNLDPLLNI LKWHLHKTVE VPFNVAQAYC IGKLKRSLGL
1270 1280 1290 1300 1310 1320
MECQCSSLTE EFYHSYLQIQ DEIPSHIMSV LDMGQGILHN LSDLYALITE QFLNYVIHKL
1330 1340 1350 1360 1370 1380
FDIDVTSYTS SDDQISIMKL PLSTKENDED FDWLEIICFH EYLSSKLNKF VSPKSVVGNF
1390 1400 1410 1420 1430 1440
VAEFKSRFFV MGEETPLLTK FVAAALHNVK CKTPTQLAET IDTICDQCVA NGVGVDIVSR
1450 1460 1470 1480 1490 1500
ISERVNRLIS YSGYKETPFL TIVNQDVKDW TDGSRGYRLQ RNIENSFGNQ ELLRLIRRGA
1510 1520 1530 1540 1550 1560
RKVFLEIKKG HVFEENLIGL IGRGGDEALR GFLLYAGFAE NDIVEALRHK WLNPSTFGDL
1570 1580 1590 1600 1610 1620
RLVLRTKIMS SKRILERESV PSLIKTLQSR MSKNFIKGAK KILAESINKS AFQSSVASGF
1630 1640 1650 1660 1670 1680
IGFCKSMGSK CVRDGKGGFM YLKELYNNVN KCGCCICLEW PGVVYCQDSL AKISQFARSI
1690 1700 1710 1720 1730 1740
LWDYFTLVLT NACEIGEWVF SDVKSPSAPP ILSNPNLFWA VKPKIQKHIE DRLSLNHILH
1750 1760 1770 1780 1790 1800
SIKRNYPYLF EEHLAPFMSD LQFNQMMNPS HVKFLDVCIA LDMMNENLGI IGHLLRGRNH
1810 1820 1830 1840 1850 1860
FIYIVKQSEC ASAHIRQSDY VDHELGLSPQ QVCYNFKVQF LFSSMIDPLI VSTSTLKTFF
1870 1880 1890 1900 1910 1920
WFNEVLSIEE EDQIDLGELT DFTLFIKTGH LNRAMTADDI TMGYVCSNLA EEIITLNSYG
1930 1940 1950 1960 1970 1980
SFQEFRSNHP SKNDLSDILK TLTSESIKLT LDIQIVHMRN STKYNISRKI VYTLKALCAL
1990 2000 2010 2020 2030 2040
PLEDCFTKDP VALVESLELF ASGVNGGHLQ LDGVTMVSVL PLLRGKKAVN LAQILMDNDL
2050 2060 2070 2080 2090 2100
AATNDHNVME SVTLDFTKFH DELGDKFCYS LVGPEDQGNP IVLHNGMFMI DNQKLSYLKV
2110 2120 2130 2140 2150 2160
EIFGDTIIKA LGALDSPREI GSLLHGLWPY LKATKQIINF DQTDFEMIYD LHRVVLLESI
2170 2180 2190 2200 2210
AQFGDWVEFA SFKVAFSKHY KDIVVADNLG NLRLKGVTCR LFRQQQSVED IE