Q6UR05

PR
Gene name
ABCC1
Protein name
Multidrug resistance-associated protein 1
Names
ATP-binding cassette sub-family C member 1, Glutathione-S-conjugate-translocating ATPase ABCC1, Leukotriene C(4) transporter, LTC4 transporter
Species
Canis lupus familiaris (Dog) (Canis familiaris)
KEGG Pathway
cfa:403453
EC number
7.6.2.2: Linked to the hydrolysis of a nucleoside triphosphate
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

239-331 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6UR05

Entry ID Method Resolution Chain Position Source
AF-Q6UR05-F1 Predicted AlphaFoldDB

1 variants for Q6UR05

Variant ID(s) Position Change Description Diseaes Association Provenance
149 A>S No

No associated diseases with Q6UR05

8 regional properties for Q6UR05

Type Name Position InterPro Accession
domain ABC transporter-like, ATP-binding domain 644 - 868 IPR003439-1
domain ABC transporter-like, ATP-binding domain 1293 - 1527 IPR003439-2
domain AAA+ ATPase domain 670 - 861 IPR003593-1
domain AAA+ ATPase domain 1319 - 1504 IPR003593-2
domain ABC transporter type 1, transmembrane domain 326 - 608 IPR011527-1
domain ABC transporter type 1, transmembrane domain 976 - 1256 IPR011527-2
conserved_site ABC transporter-like, conserved site 768 - 782 IPR017871-1
conserved_site ABC transporter-like, conserved site 1430 - 1444 IPR017871-2

Functions

Description
EC Number 7.6.2.2 Linked to the hydrolysis of a nucleoside triphosphate
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

6 GO annotations of molecular function

Name Definition
ABC-type glutathione S-conjugate transporter activity Catalysis of the reaction: ATP + H2O + glutathione S-conjugate(in) -> ADP + phosphate + glutathione S-conjugate(out).
ABC-type transporter activity Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane.
ABC-type xenobiotic transporter activity Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
hydrolase activity Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
xenobiotic transmembrane transporter activity Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.

4 GO annotations of biological process

Name Definition
leukotriene transport The directed movement of leukotrienes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Leukotrienes are linear C20 endogenous metabolites of arachidonic acid (icosa-5,8,11,14-tetraenoic acid) containing a terminal carboxy function and four or more double bonds (three or more of which are conjugated) as well as other functional groups.
lipid transport The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
positive regulation of inflammatory response Any process that activates or increases the frequency, rate or extent of the inflammatory response.
response to xenobiotic stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P14772 BPT1 Bile pigment transporter 1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q8HXQ5 ABCC1 Multidrug resistance-associated protein 1 Bos taurus (Bovine) PR
Q5U820 CFTR Cystic fibrosis transmembrane conductance regulator Canis lupus familiaris (Dog) (Canis familiaris) PR
P33527 ABCC1 Multidrug resistance-associated protein 1 Homo sapiens (Human) PR
O35379 Abcc1 Multidrug resistance-associated protein 1 Mus musculus (Mouse) PR
Q8CG09 Abcc1 Multidrug resistance-associated protein 1 Rattus norvegicus (Rat) PR
Q9C8H0 ABCC12 ABC transporter C family member 12 Arabidopsis thaliana (Mouse-ear cress) PR
Q9C8G9 ABCC1 ABC transporter C family member 1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MALRGFCSAD GSDPFWEWDV SWNTSNPDFT KCFQNTVLVW VPCCYLWLCF PFYFLYLSRH
70 80 90 100 110 120
DRGYIQMTYL NKTKTALGFV LWIVCWADLF YSFWERSWGK ILAPVFLVSP TLLGITMLLA
130 140 150 160 170 180
TFLIQLERRK GVQSSGIMLT FWLIALLCAL AILRSKIMTA LKEDAEIDVF RDVTFYIYFS
190 200 210 220 230 240
LVLIQLVLSC FSDRPPLFSE TIHDLNPCPE SSASFLSRVT FWWITGLMVR GYRQPLESTD
250 260 270 280 290 300
LWSLNKEDTS EQVVPVLVKN WKKECAKSKR QQRKITYSSK DPAKPKGGSQ VDVNEEAEVL
310 320 330 340 350 360
IVKTPQKERE PSLFKVLYKT FGPYFLMSFL FKALHDLMMF AGPEILKLLI NFVNDKKAPD
370 380 390 400 410 420
WQGYLYTALL FICACLQTLV LHQYFHICFV SGMRIKTAVI GAVYRKALVI TNSARKSSTV
430 440 450 460 470 480
GEIVNLMSVD AQRFMDLATY INMIWSAPLQ VILALYLLWL NLGPSVLAGV AVMILMVPLN
490 500 510 520 530 540
AVMAMKTKTY QVAHMKSKDN RIKLMNEILN GIKVLKLYAW ELAFKDKVLA IRQEELKVLK
550 560 570 580 590 600
KSAYLAAVGT FTWVCTPFLV ALSTFAVYVT VDKNNILDAQ KAFVSLALFN ILRFPLNILP
610 620 630 640 650 660
MVISSIVQAS VSLKRLRIFL SHEELEPDSI ERRPVKDGGG ANSITVKNAT FTWARSDPPT
670 680 690 700 710 720
LSGITFSIPE GSLVAVVGQV GCGKSSLLSA LLAEMDKVEG HVAIKGSVAY VPQQAWIQND
730 740 750 760 770 780
SLRENILFGR QLQERYYKAV IEACALLPDL EILPSGDRTE IGEKGVNLSG GQKQRVSLAR
790 800 810 820 830 840
AVYCDSDIYL FDDPLSAVDA HVGKHIFENV IGPKGMLKNK TRLLVTHSIS YLPQVDVIIV
850 860 870 880 890 900
MTGGKISEMG SYQELLARDG AFAEFLRTYA SGDQEQAEQD DGLTGVSSPG KEVKQMENGM
910 920 930 940 950 960
LVTDVAGKQL QRQLSNSSSY SGDVSRHHTS TAELQKAGPK NEDAWKLVEA DKAQTGQVKL
970 980 990 1000 1010 1020
SVYWDYMKAI GLFISFLSIF LFLCNHVASL VSNYWLSLWT DDPIVNGTQE HTKIRLSVYG
1030 1040 1050 1060 1070 1080
ALGISQGITV FGYSMAVSIG GIFASRRLHV DLLQNVLRSP MSFFERTPSG NLVNRFSKEL
1090 1100 1110 1120 1130 1140
DTVDSMIPQV IKMFMGSLFN VIGACIIILL ATPIASIIIP PLGLIYFFVQ RFYVASSRQL
1150 1160 1170 1180 1190 1200
KRLESVSRSP VYSHFNETLL GVSVIRAFEE QERFIRQSDL KVDENQKAYY PSIVANRWLA
1210 1220 1230 1240 1250 1260
VRLECVGNCI VLFAALFSVI SRHSLSAGLV GLSVSYSLQV TTYLNWLVRM SSEMETNIVA
1270 1280 1290 1300 1310 1320
VERLKEYSET EKEAPWQIQE MAPPSTWPQV GRVEFRDYGL RYRENLDLVL KHINITINGG
1330 1340 1350 1360 1370 1380
EKVGIVGRTG AGKSSLTLGL FRINESAEGE IIIDDINIAK IGLHDLRVKI TIIPQDPVLF
1390 1400 1410 1420 1430 1440
SGSLRMNLDP FSQYSDEEVW TSLELAHLKD FVSGLPDKLN QECAEGGENL SVGQRQLVCL
1450 1460 1470 1480 1490 1500
ARALLRKTKI LVLDEATAAV DLETDDLIQS TIRTQFDDCT VLTIAHRLNT IMDYTRVIVL
1510 1520 1530
DKGEIRECGQ PSDLLQQRGL FYSMAKDAGL V