Q6TUI4
Gene name |
DICER1 (DICER) |
Protein name |
Endoribonuclease Dicer |
Names |
EC 3.1.26.3 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
bta:337871 |
EC number |
|
Protein Class |
ETS (PTHR11849) |
Descriptions
GA-binding protein (GABP) is a cellular heteromeric DNA-binding protein involved in the activation of nuclear genes encoding mitochondrial proteins. The C-terminal extension of GABP alpha interferes with the DNA binding of the ETS domain. The binding of DNA to the C-terminal extension rearranges the structure of ETS domain to enhance DNA binding.
Autoinhibitory domains (AIDs)
Target domain |
1276-1404 (RNase IIIa domain);1667-1825 (RNase IIIb domain) |
Relief mechanism |
Partner binding |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6TUI4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6TUI4-F1 | Predicted | AlphaFoldDB |
No variants for Q6TUI4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6TUI4 | |||||
No associated diseases with Q6TUI4
10 regional properties for Q6TUI4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 68 - 327 | IPR000719-1 |
| domain | Protein kinase domain | 422 - 679 | IPR000719-2 |
| domain | AGC-kinase, C-terminal | 328 - 397 | IPR000961 |
| active_site | Serine/threonine-protein kinase, active site | 189 - 201 | IPR008271-1 |
| active_site | Serine/threonine-protein kinase, active site | 535 - 547 | IPR008271-2 |
| binding_site | Protein kinase, ATP binding site | 74 - 100 | IPR017441-1 |
| binding_site | Protein kinase, ATP binding site | 428 - 451 | IPR017441-2 |
| domain | Protein kinase, C-terminal | 351 - 387 | IPR017892 |
| domain | Ribosomal protein S6 kinase alpha-3, C-terminal catalytic domain | 402 - 740 | IPR041905 |
| domain | Ribosomal S6 kinase, N-terminal catalytic domain | 72 - 388 | IPR041906 |
Functions
| Description | ||
|---|---|---|
| EC Number | ||
| Subcellular Localization |
|
|
| PANTHER Family | PTHR11849 | ETS |
| PANTHER Subfamily | PTHR11849:SF195 | GA-BINDING PROTEIN ALPHA CHAIN |
| PANTHER Protein Class |
DNA-binding transcription factor
helix-turn-helix transcription factor winged helix/forkhead transcription factor |
|
| PANTHER Pathway Category |
PDGF signaling pathway Ets |
|
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| perinuclear region of cytoplasm | Cytoplasm situated near, or occurring around, the nucleus. |
| RISC complex | A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation. |
| RISC-loading complex | A trimeric protein complex required for the formation of a mature RNA-induced silencing complex (RISC). In humans the complex is composed of the endonuclease Dicer (DICER1), TRBP (TARBP2) and the Argonaute protein Ago2 (EIF2C2/AGO2). Within the complex, Dicer and TRBP are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto Ago2. Ago2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from Dicer and TRBP. This complex has endoribonuclease activity. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| deoxyribonuclease I activity | Catalysis of the endonucleolytic cleavage of DNA to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end products. |
| helicase activity | Catalysis of the reaction |
| metal ion binding | Binding to a metal ion. |
| ribonuclease III activity | Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| apoptotic DNA fragmentation | The cleavage of DNA during apoptosis, which usually occurs in two stages |
| global gene silencing by mRNA cleavage | A posttranscriptional gene silencing pathway that involves the cleavage of mRNAs in a non-gene-specific manner. |
| pre-miRNA processing | A process involved in the conversion of a pre-microRNA transcript into a mature microRNA molecule. |
| siRNA processing | A process leading to the generation of a functional small interfering RNA (siRNA). Includes the cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides. May also include amplification of the siRNA by RNA-directed RNA polymerase. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q25BN1 | DICER1 | Endoribonuclease Dicer | Gallus gallus (Chicken) | SS |
| Q9UPY3 | DICER1 | Endoribonuclease Dicer | Homo sapiens (Human) | EV |
| Q8R418 | Dicer1 | Endoribonuclease Dicer | Mus musculus (Mouse) | SS |
| Q6ATG6 | Os05g0271300 | Ribonuclease 3-like protein 2 | Oryza sativa subsp japonica (Rice) | PR |
| P34529 | dcr-1 | Endoribonuclease dcr-1 | Caenorhabditis elegans | PR |
| B3DLA6 | dicer1 | Endoribonuclease Dicer | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | SS |
| Q6TV19 | dicer1 | Endoribonuclease Dicer | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTKREAEELI | EIEIDGTEKA | ECTEESIVEQ | TYTPAECVSQ | AIDINEPIGN | LKKLLEPRLQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| CSLDAHEICL | QDIQLDPDRS | LFDQGVKTDG | TVQLSVQVIS | YQGMEPKLNI | LEIVKTAETV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EVVIDPDAHH | AEAEAHLVEE | AQVITLDGTK | HITTISDETS | EQVTRWAAAL | EGYRKEQERL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GIPYDPIHWS | TDQVLHWVVW | VMKEFSMTDI | DLTTLNISGR | ELCSLNQEDF | FQRVPRGEIL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| WSHLELLRKY | VLASQEQQMN | EIVTIDQPVQ | IIPASVPPAT | PTTIKVINSS | AKAAKVQRSP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RISGEDRSSP | GNRTGNNGQI | QLWQFLLELL | TDKDARDCIS | WVGDEGEFKL | NQPELVAQKW |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GQRKNKPTMN | YEKLSRALRY | YYDGDMICKV | QGKRFVYKFV | CDLKTLIGYS | AAELNRLVIE |
| 430 | 440 | 450 | |||
| CEQKKLARMQ | LHGIAQPVTA | VALAATSLQA | DKEI |