Q6TA49

PR
Gene name
IYD (DEHAL1)
Protein name
Iodotyrosine deiodinase 1
Names
IYD-1, Iodotyrosine dehalogenase 1
Species
Sus scrofa (Pig)
KEGG Pathway
ssc:403124
EC number
1.21.1.1: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-114 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6TA49

Entry ID Method Resolution Chain Position Source
AF-Q6TA49-F1 Predicted AlphaFoldDB

No variants for Q6TA49

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6TA49

No associated diseases with Q6TA49

1 regional properties for Q6TA49

Type Name Position InterPro Accession
domain Nitroreductase 98 - 267 IPR029479

Functions

Description
EC Number 1.21.1.1 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
  • Cell membrane ; Single-pass membrane protein
  • Cytoplasmic vesicle membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasmic vesicle membrane The lipid bilayer surrounding a cytoplasmic vesicle.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

2 GO annotations of molecular function

Name Definition
FMN binding Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
iodotyrosine deiodinase activity Catalyzes the reaction: 2 iodide + L-tyrosine + 2 NADP+ = 3,5-diiodo-L-tyrosine + H+ + 2 NADPH. Note that this activity has only been demonstrated in the direction of 3-deiodination. 3-bromo-L-tyrosine and 3-chloro-L-tyrosine can also be used as substrates.

2 GO annotations of biological process

Name Definition
thyroid hormone metabolic process The chemical reactions and pathways involving any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine.
tyrosine metabolic process The chemical reactions and pathways involving tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MFLLTPVLVA VVCILMVWIF KNADGATKRR EEEPRARAEA RPWVDEDLKD STDVLQVEED
70 80 90 100 110 120
ADEWQESEEE VEHVPFSHTR YPEKEMVRRS QEFYELLNKR RSVRFISNER VPMEVIDNVI
130 140 150 160 170 180
KAAGTAPSGA HTEPWTFVVV KDPDVKHRIR EIMEEEEKIN YLKRMGPRWV TDLKKLRTNW
190 200 210 220 230 240
IKEYWDTAPV LILIFKQVHG FAANGKKKIH YYNEISVSIA CGIFLAALQN AGLVTVTTTP
250 260 270 280
FNCGPRLRVF LNRPANEKLL MFLPVGYPSK EATVPDLPRK PLDQIMVTV